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... Understanding the mechanism underlying  p53 
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... findings suggesting a pro-oncogenic role for  p53 
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Girardini, Javier E.; Walerych, Dawid; Sal, Giannino
point mutants, more than 30 years of research ...
... Background MCT-1 oncoprotein accelerates  p53 
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Kasiappan, Ravi; Shih, Hung-Ju; Wu, Meng-Hsun; Choy, ChikOn; Lin, Tai-Du; Chen, Linyi; Hsu, Hsin-Ling
protein degradation via a proteosome pathway. ...
... The presence of a functional  p53 
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
Levav-Cohen, Yaara; Goldberg, Zehavit; Tan, Kah Hin; Alsheich-Bartok, Osnat; Zuckerman, Valentina; Haupt, Sue; Haupt, Ygal
protein is a key factor for the proper ...
... in the genesis and progression of cancer, mutant  p53 
Mutant p53 and the Response to Chemotherapy and Radiation
Mutant p53 and the Response to Chemotherapy and Radiation
Tchelebi, Leila; Ashamalla, Hani; Graves, Paul R.
also appears to play a significant role in the ...
... The tumor suppressor  p53 
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Zhang, Qi; Zeng, Shelya X.; Lu, Hua
plays a central role in anti-tumorigenesis and ...
... point mutation of TP53 or through disruption of  p53 
p53 in Head and Neck Cancer
p53 in Head and Neck Cancer
Roh, Jong-Lyel; Koch, Wayne M.
protein function as a consequence of oncogenic ...
... The  p53 
p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
Giono, Luciana E.; Ladelfa, M. Fátima; Monte, Martín
tumor suppressor is a transcription factor that ...
... no curative treatments. While mutation of the  P53 
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
Avery-Kiejda, Kelly A; Bowden, Nikola A; Croft, Amanda J; Scurr, Lyndee L; Kairupan, Carla F; Ashton, Katie A; Talseth-Palmer, Bente A; Rizos, Helen; Zhang, Xu D; Scott, Rodney J; Hersey, Peter
tumour suppressor gene is a common feature of ...
... MTI-induced cell death. Especially, the role of  p53 
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
Kim, Jae Hyeong; Yoon, Eun-Kyung; Chung, Hye-Jin; Park, Seong-Yeol; Hong, Kyeong-Man; Lee, Chang-Hun; Lee, Yeon-Su; Choi, Kyungho; Yang, Young; Kim, Kyungtae; Kim, In-Hoo
in this process has been controversial for a long ...
... Mutations in the TP53 gene or the  p53 
p53 Pathway Alterations in Brain Tumors
p53 Pathway Alterations in Brain Tumors
Yin, Shaoman; Van Meir, Erwin G.
pathway are required for the formation of many ...
... of glutathione (GSH) and dependency of  p53 
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Banerjee, Kaushik; Das, Satyajit; Majumder, Saikat; Majumdar, Subrata; Biswas, Jaydip; Choudhuri, Soumitra Kumar
status on the modulation of GSH-mediated ...
... harbor mutations in the tumor suppressor  p53 
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Chander, Harish; Brien, Colin D; Truesdell, Peter; Watt, Kathleen; Meens, Jalna; Schick, Colleen; Germain, Doris; Craig, Andrew WB
, we tested whether ...
... accumulation of PTEN and its interaction with  p53 
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Das, Ranjita; Bhattacharya, Kaushik; Sarkar, Sayantani; Samanta, Suman Kumar; Pal, Bikas C.; Mandal, Chitra
/p73. ...
... of ING proteins is their cooperation with  p53 
Regulation of p53 by ING family members in suppression of tumor initiation and progression
Regulation of p53 by ING family members in suppression of tumor initiation and progression
Jafarnejad, Seyed Mehdi; Li, Gang
tumor suppressor protein in tumor suppression. ...
... pathways or cell cycle arrest. High frequency of  p53 
Sentinel Gene Within Cell Territory and Molecular Platforms in Cancer: Methylation Diversity of p53 Gene in Brain Tumors
Sentinel Gene Within Cell Territory and Molecular Platforms in Cancer: Methylation Diversity of p53 Gene in Brain Tumors
Mehdipour, Parvin; Karami, Fatemeh
gene aberrations in various types of cancer has ...
... Loss of function of  p53 
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Yu, Xin; Narayanan, Sumana; Vazquez, Alexei; Carpizo, Darren R.
, either through mutations in the gene or through ...
... Background  p53 
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Zhang, Lili; Nie, Linghu; Maki, Carl G
is a tumor suppressor and potent inhibitor of ...
... Methods We performed computer modeling of the  p53 
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Golubovskaya, Vita M; Ho, Baotran; Zheng, Min; Magis, Andrew; Ostrov, David; Morrison, Carl; Cance, William G
peptide containing the site of interaction with ...
... caused by the expression of BCR-ABL. Loss of  p53 
Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage
Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage
Kusio-Kobialka, Monika; Wolanin, Kamila; Podszywalow-Bartnicka, Paulina; Sikora, Ewa; Skowronek, Krzysztof; McKenna, Sharon L.; Ghizzoni, Massimo; Dekker, Frank J.; Piwocka, Katarzyna
has not been implicated as important for the ...
... reactivity against the tumor suppressor protein  p53 
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
Met, Özcan; Balslev, Eva; Flyger, Henrik; Svane, Inge Marie
in breast cancer patients (BCP) at the time point ...
... Tumor suppressor  p53 
The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism
The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism
Budanov, Andrei V.
is inactivated in most cancers and the critical ...
... Background Activation of  p53 
HIPK2 modulates p53 activity towards pro-apoptotic transcription
HIPK2 modulates p53 activity towards pro-apoptotic transcription
Puca, Rosa; Nardinocchi, Lavinia; Sacchi, Ada; Rechavi, Gideon; Givol, David; D'Orazi, Gabriella
-mediated gene transcription is a critical ...
... further the interaction between BM2 and  p53 
The BM2 protein of influenza B virus interacts with p53 and inhibits its transcriptional and apoptotic activities
The BM2 protein of influenza B virus interacts with p53 and inhibits its transcriptional and apoptotic activities
Zhang, H.; Yu, H.; Wang, J.; Zhang, M.; Wang, X.; Ahmad, W.; Duan, M.; Guan, Z.
to confirm our previous studies using yeast ...
... Background The tumor suppressor  p53 
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Bisio, Alessandra; De Sanctis, Veronica; Del Vescovo, Valerio; Denti, Michela A; Jegga, Anil G; Inga, Alberto; Ciribilli, Yari
is a sequence-specific transcription factor that ...

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