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... Understanding the mechanism underlying  p53 
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... The  p53 
p53
p53
Tsai, Wen-Wei; Barton, Michelle Craig
tumor suppressor is well known as the major ...
... reactivity against the tumor suppressor protein  p53 
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
Met, Özcan; Balslev, Eva; Flyger, Henrik; Svane, Inge Marie
in breast cancer patients (BCP) at the time point ...
... Purpose  p53 
Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment
Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment
Kraljević Pavelić, Sandra; Marjanović, Marko; Poznić, Miroslav; Kralj, Marijeta
gene plays a crucial role in the response to ...
... Introduction  p53 
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Zhao, Kai; Zhou, Yuxin; Qiao, Chen; Ni, Ting; Li, Zhiyu; Wang, Xiaotang; Guo, Qinglong; Lu, Na; Wei, Libin
plays important roles in regulating the metabolic ...
... a variety of human cancers containing the mutant  p53 
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism
Hori, Makoto; Suzuki, Keiji; Udono, Masako U.; Yamauchi, Motohiro; Mine, Mariko; Watanabe, Masami; Kondo, Shigeo; Hozumi, Yutaka
(mt- ...
... harbor somatic mutations of the tumor suppressor  p53 
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
Guo, Gang; Cui, Yan
( ...
... poorly known. We identify the presence of three  p53 
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Kelkar, Madhura G.; Thakur, Bhushan; Derle, Abhishek; Chatterjee, Sushmita; Ray, Pritha; De, Abhijit
binding sites on the human NIS promoter sequence ...
... is the multifunctional transcription factor  p53 
p53 Replacement Therapy for Cancer
p53 Replacement Therapy for Cancer
Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi
gene that regulates diverse cellular phenomena ...
... Although the preoperative serum level of  p53 
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Yamashita, Kotaro; Makino, Tomoki; Tanaka, Koji; Yamasaki, Makoto; Yamamoto, Masaaki; Miyazaki, Yasuhiro; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro
antibodies (s- ...
... (CD71, CARM1, PI3KCA&TK1), P-cadherin,  p53 
ESP Abstracts 2012
ESP Abstracts 2012
and with lower levels of ER expression and ...
... Here, we examine the impact of ERβ on the ERα-  p53 
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer
Lu, Wenwen; Katzenellenbogen, Benita S.
loop in breast cancer. ...
... Recent work has shown that the basal level of  p53 
p53 regulates LIF expression in human medulloblastoma cells
p53 regulates LIF expression in human medulloblastoma cells
Baxter, Euan W.; Milner, Jo
plays an important role in maternal reproduction ...
... To further elucidate the significance of  p53 
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Feng, Yu-Zhen; Shiozawa, Tanri; Horiuchi, Akiko; Shih, Hsien-Chang; Miyamoto, Tsutomu; Kashima, Hiroyasu; Suzuki, Akihisa; Nikaido, Toshio; Konishi, Ikuo
mutation in endometrial carcinoma, we ...
...  p53 
Isolation of p53 Inhibitors by Screening Chemical Libraries in Cell-Based Readout System
Isolation of p53 Inhibitors by Screening Chemical Libraries in Cell-Based Readout System
Gudkov, Andrei; Komarova, Elena
is a key mediator of cell response to a variety ...
... Lymphomas frequently retain wild-type (wt)  p53 
HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas
HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas
Sosin, Angela M; Burger, Angelika M; Siddiqi, Aisha; Abrams, Judith; Mohammad, Ramzi M; Al-Katib, Ayad M
function but overexpress HDM2, thereby ...
... extended to three candidate HLA-DR–restricted  p53 
Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ1*0101– and HLA-DRβ1*0401–restricted epitope from p53
Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ1*0101– and HLA-DRβ1*0401–restricted epitope from p53
Rojas, José Manuel; McArdle, Stephanie E. B.; Horton, Roger B. V.; Bell, Matthew; Mian, Shahid; Li, Geng; Ali, Selman A.; Rees, Robert C.
peptides predicted by the evidence-based ...
... Background Accumulated evidence suggests that  p53 
Potential Increase in the Prognostic Value of p53 Mutation by Pro72 Allele in Stage I Non-Small-Cell Lung Cancer
Potential Increase in the Prognostic Value of p53 Mutation by Pro72 Allele in Stage I Non-Small-Cell Lung Cancer
Chien, Wen-Pin; Wong, Ruey-Hong; Wu, Tsu-Chin; Cheng, Ya-Wen; Chen, Chih-Yi; Lee, Huei
function altered by its gene mutation or genetic ...
... on apoptosis induction in wild-type and mutant  p53 
Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells
Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells
Stravopodis, Dimitrios J.; Karkoulis, Panagiotis K.; Konstantakou, Eumorphia G.; Melachroinou, Sophia; Thanasopoulou, Angeliki; Aravantinos, Gerasimos; Margaritis, Lukas H.; Anastasiadou, Ema; Voutsinas, Gerassimos E.
urinary bladder cancer cells. ...
... mechanisms underlying dysregulated wild type (wt)  p53 
Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis
Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis
Abdi, Jahangir; Rastgoo, Nasrin; Li, Lihong; Chen, Wenming; Chang, Hong
in multiple myeloma (MM) have been subjects of ...
... a phase I clinical trial. Enhancement of  p53 
Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells
Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells
Oh, Eun-Taex; Park, Moon-Taek; Choi, Bo-Hwa; Ro, Seonggu; Choi, Eun-Kyung; Jeong, Seong-Yun; Park, Heon Joo
acetylation by HDAC inhibitors induces cell cycle ...
... The  p53 
Clinical Implications of p53 Mutations in Lung Cancer
Clinical Implications of p53 Mutations in Lung Cancer
Campling, Barbara G.; El-Deiry, Wafik S.
tumor-suppressor gene plays a crucial role in the ...
... Dominant-negative somatic mutations of  p53 
p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis
p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis
Zhang, Ting; Li, Huihua; Shi, Juan; Li, Sha; Li, Muyuan; Zhang, Lei; Zheng, Leting; Zheng, Dexian; Tang, Fulin; Zhang, Xuan; Zhang, Fengchun; You, Xin
has been identified in the synovium of patients ...
... elements in the coding region and a putative  p53 
Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells
Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells
Pratt, M. A. Christine; White, Dawn; Kushwaha, Neena; Tibbo, Emma; Niu, Min Ying
negative regulatory element (NRE) containing a ...
... by expression plasmids that encode mutant  p53 
DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis
DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis
Humar, Matjaz; Maurer, Martina; Azemar, Marc; Groner, Bernd
was conducted to characterize exogenously induced ...