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... by this role of nucleoli is the tumor suppressor  p53 
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Vlatković, Nikolina; Boyd, Mark T.; Rubbi, Carlos P.
, which is activated in response to diverse ...
... The tumor suppressor  p53 
Molecularly targeted therapies for p53-mutant cancers
Molecularly targeted therapies for p53-mutant cancers
Zhao, Dekuang; Tahaney, William M.; Mazumdar, Abhijit; Savage, Michelle I.; Brown, Powel H.
is lost or mutated in approximately half of human ...
... Background The  p53 
Impact of Alu repeats on the evolution of human p53 binding sites
Impact of Alu repeats on the evolution of human p53 binding sites
Cui, Feng; Sirotin, Michael V; Zhurkin, Victor B
tumor suppressor protein is involved in a ...
...  p53 
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Giono, Luciana E.; Manfredi, James J.
is a widely conserved tumor suppressor protein ...
... of glutathione (GSH) and dependency of  p53 
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Banerjee, Kaushik; Das, Satyajit; Majumder, Saikat; Majumdar, Subrata; Biswas, Jaydip; Choudhuri, Soumitra Kumar
status on the modulation of GSH-mediated ...
... Background  p53 
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
Brynczka, Christopher; Labhart, Paul; Merrick, B Alex
is recognized as a critical regulator of the cell ...
... Background The tumor suppressor protein  p53 
p53 induces distinct epigenetic states at its direct target promoters
p53 induces distinct epigenetic states at its direct target promoters
Vrba, Lukas; Junk, Damian J; Novak, Petr; Futscher, Bernard W
is a transcription factor that is mutated in many ...
... As a critical tumor suppressor,  p53 
Functional analysis of the acetylation of human p53 in DNA damage responses
Functional analysis of the acetylation of human p53 in DNA damage responses
Chung, Sun-Ku; Zhu, Shengyun; Xu, Yang; Fu, Xuemei
is inactivated in human cancer cells by somatic ...
... Background The  p53 
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Chen, Xi; Chen, Jia; Gan, Siting; Guan, Huaji; Zhou, Yuan; Ouyang, Qi; Shi, Jue
pathway is differentially activated in response ...
... further the interaction between BM2 and  p53 
The BM2 protein of influenza B virus interacts with p53 and inhibits its transcriptional and apoptotic activities
The BM2 protein of influenza B virus interacts with p53 and inhibits its transcriptional and apoptotic activities
Zhang, H.; Yu, H.; Wang, J.; Zhang, M.; Wang, X.; Ahmad, W.; Duan, M.; Guan, Z.
to confirm our previous studies using yeast ...
... linked at the molecular level. Results Blocking  p53 
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Villiard, Éric; Brinkmann, Henner; Moiseeva, Olga; Mallette, Frédérick A; Ferbeyre, Gerardo; Roy, Stéphane
signaling in axolotls using the ...
...  p53 
Senescence Regulation by the p53 Protein Family
Senescence Regulation by the p53 Protein Family
Qian, Yingjuan; Chen, Xinbin
, a guardian of the genome, exerts its tumor ...
... fate. Mutations within the TP53 (tumor suppressor  p53 
p53 regulates cytoskeleton remodeling to suppress tumor progression
p53 regulates cytoskeleton remodeling to suppress tumor progression
Araki, Keigo; Ebata, Takahiro; Guo, Alvin Kunyao; Tobiume, Kei; Wolf, Steven John; Kawauchi, Keiko
) gene leading to loss or gain of function (GOF) ...
... viability and subtle developmental defects of  p53 
Embryonic stem cells shed new light on the developmental roles of p53
Embryonic stem cells shed new light on the developmental roles of p53
Shin, Min Hwa; He, Yunlong; Huang, Jing
knockout mice suggest that ...
... Background The master regulator  p53 
Dissecting microregulation of a master regulatory network
Dissecting microregulation of a master regulatory network
Sinha, Amit U; Kaimal, Vivek; Chen, Jing; Jegga, Anil G
tumor-suppressor protein through coordination of ...
... oxygen species during wound repair responses.  p53 
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
Mizuguchi, Yoshiaki; Specht, Susan; Lunz, John G, III; Isse, Kumiko; Corbitt, Natasha; Takizawa, Toshihiro; Demetris, Anthony J
is also widely recognized as the node in cellular ...
... Background The tumor suppressor protein  p53 
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
Loewer, Alexander; Karanam, Ketki; Mock, Caroline; Lahav, Galit
is activated by cellular stress. ...
... Background The  p53 
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
Turenne, Gaetan A; Price, Brendan D
protein is activated by genotoxic stress, ...
... Background The  p53 
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Wachter, Franziska; Grunert, Michaela; Blaj, Cristina; Weinstock, David M; Jeremias, Irmela; Ehrhardt, Harald
protein is the best studied target in human ...
... expression, carry a missense mutation at the  p53 
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Gottschalk, Benjamin; Klein, Andreas
codon 242 (mouse G242 corresponds to human hot ...
... Background The tumour suppressor protein  p53 
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
Bereczki, Orsolya; Ujfaludi, Zsuzsanna; Pardi, Norbert; Nagy, Zita; Tora, Laszlo; Boros, Imre M; Balint, Eva
is a sequence specific DNA-binding transcription ...
... Background The  p53 
Regression based predictor for p53 transactivation
Regression based predictor for p53 transactivation
Gowrisankar, Sivakumar; Jegga, Anil G
protein is a master regulator that controls the ...
... Tumor suppressor  p53 
Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
Kim, Young June; Kim, Tae-Hyun; Kim, Minjeong; Kim, Min Ju; Kim, Hae-Won; Shim, Hosup
plays a critical role in the regulation of cell ...
... of the human tumor suppressor protein  P53 
Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast
Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast
Kamoun, Yosra; Mabrouk, Imed; Delahodde, Agnes; Boukid, Fatma; Yacoubi-Hadj Amor, Ines; Mokdad-Gargouri, Raja; Gargouri, Ali
causes cell death of the yeast Saccharomyces ...
... cells. HCT 116 colorectal cancer cells expressing  p53 
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Beaino, Wissam; Guo, Yunjun; Chang, Albert J.; Anderson, Carolyn J.
(+/+) and not expressing ...