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... In this work we present evidence that the  p53 
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Dreyfus, David H; Nagasawa, Masayuki; Gelfand, Erwin W; Ghoda, Lucy Y
tumor suppressor protein and NF-κB transcription ...
... Background MCT-1 oncoprotein accelerates  p53 
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Kasiappan, Ravi; Shih, Hung-Ju; Wu, Meng-Hsun; Choy, ChikOn; Lin, Tai-Du; Chen, Linyi; Hsu, Hsin-Ling
protein degradation via a proteosome pathway. ...
... Background The  p53 
Impact of Alu repeats on the evolution of human p53 binding sites
Impact of Alu repeats on the evolution of human p53 binding sites
Cui, Feng; Sirotin, Michael V; Zhurkin, Victor B
tumor suppressor protein is involved in a ...
... no curative treatments. While mutation of the  P53 
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
Avery-Kiejda, Kelly A; Bowden, Nikola A; Croft, Amanda J; Scurr, Lyndee L; Kairupan, Carla F; Ashton, Katie A; Talseth-Palmer, Bente A; Rizos, Helen; Zhang, Xu D; Scott, Rodney J; Hersey, Peter
tumour suppressor gene is a common feature of ...
... of Alzheimer's disease. The transcription factor,  p53 
GSK3 and p53 - is there a link in Alzheimer's disease?
GSK3 and p53 - is there a link in Alzheimer's disease?
Proctor, Carole J; Gray, Douglas A
also plays a role and has been linked to an ...
... harbor mutations in the tumor suppressor  p53 
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Chander, Harish; Brien, Colin D; Truesdell, Peter; Watt, Kathleen; Meens, Jalna; Schick, Colleen; Germain, Doris; Craig, Andrew WB
, we tested whether ...
... Background  p53 
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
Brynczka, Christopher; Labhart, Paul; Merrick, B Alex
is recognized as a critical regulator of the cell ...
... Background  p53 
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Zhang, Lili; Nie, Linghu; Maki, Carl G
is a tumor suppressor and potent inhibitor of ...
... Methods We performed computer modeling of the  p53 
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Golubovskaya, Vita M; Ho, Baotran; Zheng, Min; Magis, Andrew; Ostrov, David; Morrison, Carl; Cance, William G
peptide containing the site of interaction with ...
... Background The tumor suppressor protein  p53 
p53 induces distinct epigenetic states at its direct target promoters
p53 induces distinct epigenetic states at its direct target promoters
Vrba, Lukas; Junk, Damian J; Novak, Petr; Futscher, Bernard W
is a transcription factor that is mutated in many ...
... Background The  p53 
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Chen, Xi; Chen, Jia; Gan, Siting; Guan, Huaji; Zhou, Yuan; Ouyang, Qi; Shi, Jue
pathway is differentially activated in response ...
... Background Activation of  p53 
HIPK2 modulates p53 activity towards pro-apoptotic transcription
HIPK2 modulates p53 activity towards pro-apoptotic transcription
Puca, Rosa; Nardinocchi, Lavinia; Sacchi, Ada; Rechavi, Gideon; Givol, David; D'Orazi, Gabriella
-mediated gene transcription is a critical ...
... Background The  p53 
Evolution of the p53-MDM2 pathway
Evolution of the p53-MDM2 pathway
Åberg, Emma; Saccoccia, Fulvio; Grabherr, Manfred; Ore, Wai Ying Josefin; Jemth, Per; Hultqvist, Greta
signalling pathway, which controls cell fate, has ...
... linked at the molecular level. Results Blocking  p53 
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Villiard, Éric; Brinkmann, Henner; Moiseeva, Olga; Mallette, Frédérick A; Ferbeyre, Gerardo; Roy, Stéphane
signaling in axolotls using the ...
... Background The tumor suppressor  p53 
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Bisio, Alessandra; De Sanctis, Veronica; Del Vescovo, Valerio; Denti, Michela A; Jegga, Anil G; Inga, Alberto; Ciribilli, Yari
is a sequence-specific transcription factor that ...
... as well as induction of apoptosis through  p53 
PTTG/securin activates expression of p53 and modulates its function
PTTG/securin activates expression of p53 and modulates its function
Hamid, Tariq; Kakar, Sham S
-dependent and ...
... Background  p53 
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Ajay, Amrendra K; Upadhyay, Ankur K; Singh, Sandeep; Vijayakumar, Maleppillil V; Kumari, Ratna; Pandey, Vimal; Boppana, Ramanamurthy; Bhat, Manoj K
is the most studied tumor suppressor and its ...
... induced claudin-low-like TNBC. The effect of  p53 
Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Wang, Sharon; Liu, Jeff C.; Kim, Danbi; Datti, Alessandro; Zacksenhaus, Eldad
mutation plus Pten deletion on mammary ...
... Introduction  p53 
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Zhao, Kai; Zhou, Yuxin; Qiao, Chen; Ni, Ting; Li, Zhiyu; Wang, Xiaotang; Guo, Qinglong; Lu, Na; Wei, Libin
plays important roles in regulating the metabolic ...
... that can restore biological activity of mutant  p53 
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Knowell, Ashley E; Patel, Divya; Morton, Derrick J; Sharma, Pankaj; Glymph, Shanora; Chaudhary, Jaideep
are an area of high interest given that mutant ...
... harbor somatic mutations of the tumor suppressor  p53 
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
Guo, Gang; Cui, Yan
( ...
... Background The function of  p53 
The impact of p53 on the early stage replication of retrovirus
The impact of p53 on the early stage replication of retrovirus
Kinnetz, Michaela; Alghamdi, Faris; Racz, Michael; Hu, Wenwei; Shi, Binshan
in cancer biology has been studied extensively, ...
... the function of tumor suppressor protein  p53 
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Dixit, Updesh; Liu, Zhihe; Pandey, Ashutosh K; Kothari, Ramesh; Pandey, Virendra N
. ...
... and validated the assay using inhibitors of the  p53 
A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53
A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53
Wong, Jin Huei; Alfatah, Mohammad; Sin, Mei Fang; Sim, Hong May; Verma, Chandra S.; Lane, David P.; Arumugam, Prakash
-Mdm2 interaction and identified a hitherto ...
... viability and subtle developmental defects of  p53 
Embryonic stem cells shed new light on the developmental roles of p53
Embryonic stem cells shed new light on the developmental roles of p53
Shin, Min Hwa; He, Yunlong; Huang, Jing
knockout mice suggest that ...

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