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... Understanding the mechanism underlying  p53 
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... by this role of nucleoli is the tumor suppressor  p53 
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Vlatković, Nikolina; Boyd, Mark T.; Rubbi, Carlos P.
, which is activated in response to diverse ...
... In this work we present evidence that the  p53 
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Dreyfus, David H; Nagasawa, Masayuki; Gelfand, Erwin W; Ghoda, Lucy Y
tumor suppressor protein and NF-κB transcription ...
... Background MCT-1 oncoprotein accelerates  p53 
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Kasiappan, Ravi; Shih, Hung-Ju; Wu, Meng-Hsun; Choy, ChikOn; Lin, Tai-Du; Chen, Linyi; Hsu, Hsin-Ling
protein degradation via a proteosome pathway. ...
... The tumor suppressor  p53 
Molecularly targeted therapies for p53-mutant cancers
Molecularly targeted therapies for p53-mutant cancers
Zhao, Dekuang; Tahaney, William M.; Mazumdar, Abhijit; Savage, Michelle I.; Brown, Powel H.
is lost or mutated in approximately half of human ...
... Here, we have studied in  p53 
C-terminal region of human p53 attenuates buffalo p53 N-terminal-specific transactivation of p21 promoter by modulating tetramerization of the protein
C-terminal region of human p53 attenuates buffalo p53 N-terminal-specific transactivation of p21 promoter by modulating tetramerization of the protein
Singh, Minu; Mukhopadhyay, Tapas
null H1299 lung carcinoma cells, the ...
... Background The  p53 
Impact of Alu repeats on the evolution of human p53 binding sites
Impact of Alu repeats on the evolution of human p53 binding sites
Cui, Feng; Sirotin, Michael V; Zhurkin, Victor B
tumor suppressor protein is involved in a ...
...  p53 
Exonucleolytic degradation of RNA by p53 protein in cytoplasm
Exonucleolytic degradation of RNA by p53 protein in cytoplasm
Bakhanashvili, Mary; Gedelovich, Rachel; Grinberg, Shai; Rahav, Galia
in cytoplasm displays an intrinsic 3′→5′ ...
...  p53 
Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
Regeling, Anouk; Armata, Heather L.; Gallant, Judy; Jones, Stephen N.; Sluss, Hayla K.
is a major suppressor of human malignancy. ...
... The tumour suppressor  p53 
The role of DNA damage responses in p53 biology
The role of DNA damage responses in p53 biology
Speidel, Daniel
is a central player in cellular DNA damage ...
... no curative treatments. While mutation of the  P53 
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
Avery-Kiejda, Kelly A; Bowden, Nikola A; Croft, Amanda J; Scurr, Lyndee L; Kairupan, Carla F; Ashton, Katie A; Talseth-Palmer, Bente A; Rizos, Helen; Zhang, Xu D; Scott, Rodney J; Hersey, Peter
tumour suppressor gene is a common feature of ...
... of Alzheimer's disease. The transcription factor,  p53 
GSK3 and p53 - is there a link in Alzheimer's disease?
GSK3 and p53 - is there a link in Alzheimer's disease?
Proctor, Carole J; Gray, Douglas A
also plays a role and has been linked to an ...
... MTI-induced cell death. Especially, the role of  p53 
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
Kim, Jae Hyeong; Yoon, Eun-Kyung; Chung, Hye-Jin; Park, Seong-Yeol; Hong, Kyeong-Man; Lee, Chang-Hun; Lee, Yeon-Su; Choi, Kyungho; Yang, Young; Kim, Kyungtae; Kim, In-Hoo
in this process has been controversial for a long ...
... The human mutant  p53 
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Duan, Wenrui; Gao, Li; Jin, David; Otterson, Gregory A.; Villalona-Calero, Miguel A.
(273H) has been shown in vitro to have both ...
... in each subtype, alterations of tumor suppressor  p53 
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
England, Bryant; Huang, Tiangui; Karsy, Michael
are the most common, seen in 25–30 % of primary ...
... of glutathione (GSH) and dependency of  p53 
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Banerjee, Kaushik; Das, Satyajit; Majumder, Saikat; Majumdar, Subrata; Biswas, Jaydip; Choudhuri, Soumitra Kumar
status on the modulation of GSH-mediated ...
... harbor mutations in the tumor suppressor  p53 
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Chander, Harish; Brien, Colin D; Truesdell, Peter; Watt, Kathleen; Meens, Jalna; Schick, Colleen; Germain, Doris; Craig, Andrew WB
, we tested whether ...
... accumulation of PTEN and its interaction with  p53 
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Das, Ranjita; Bhattacharya, Kaushik; Sarkar, Sayantani; Samanta, Suman Kumar; Pal, Bikas C.; Mandal, Chitra
/p73. ...
... of ING proteins is their cooperation with  p53 
Regulation of p53 by ING family members in suppression of tumor initiation and progression
Regulation of p53 by ING family members in suppression of tumor initiation and progression
Jafarnejad, Seyed Mehdi; Li, Gang
tumor suppressor protein in tumor suppression. ...
... Loss of function of  p53 
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Yu, Xin; Narayanan, Sumana; Vazquez, Alexei; Carpizo, Darren R.
, either through mutations in the gene or through ...
... Background  p53 
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
Brynczka, Christopher; Labhart, Paul; Merrick, B Alex
is recognized as a critical regulator of the cell ...
... Background  p53 
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Zhang, Lili; Nie, Linghu; Maki, Carl G
is a tumor suppressor and potent inhibitor of ...
... Methods We performed computer modeling of the  p53 
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Golubovskaya, Vita M; Ho, Baotran; Zheng, Min; Magis, Andrew; Ostrov, David; Morrison, Carl; Cance, William G
peptide containing the site of interaction with ...
... Background The tumor suppressor protein  p53 
p53 induces distinct epigenetic states at its direct target promoters
p53 induces distinct epigenetic states at its direct target promoters
Vrba, Lukas; Junk, Damian J; Novak, Petr; Futscher, Bernard W
is a transcription factor that is mutated in many ...
... caused by the expression of BCR-ABL. Loss of  p53 
Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage
Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage
Kusio-Kobialka, Monika; Wolanin, Kamila; Podszywalow-Bartnicka, Paulina; Sikora, Ewa; Skowronek, Krzysztof; McKenna, Sharon L.; Ghizzoni, Massimo; Dekker, Frank J.; Piwocka, Katarzyna
has not been implicated as important for the ...

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