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... in each subtype, alterations of tumor suppressor  p53 
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
England, Bryant; Huang, Tiangui; Karsy, Michael
are the most common, seen in 25–30 % of primary ...
... time. Codon-specific hotspot mutations of  p53 
The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma
The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma
Karsy, Michael; Albert, Ladislau; Murali, Raj; Jhanwar-Uniyal, Meena
result in constitutively active mutant ...
... In this study, we studied the effects of  p53 
p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells
p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells
Wang, Mei-Juan; Pei, Dong-Sheng; Qian, Guo-Wei; Yin, Xiao-Xing; Cheng, Qian; Li, Lian-Tao; Li, Hui-Zhong; Zheng, Jun-Nian
on Ki-67 promoter in HeLa cells using luciferase ...
... We investigated the role of BRCA1, MDM2, and  p53 
BRCA1 and MDM2 as independent blood-based biomarkers of head and neck cancer
BRCA1 and MDM2 as independent blood-based biomarkers of head and neck cancer
Bhowmik, Aditi; Das, Sambuddha; Bhattacharjee, Abhinandan; Choudhury, Biswadeep; Naiding, Momota; Ghosh, Sankar Kumar; Choudhury, Yashmin
in the pathogenesis of head and neck cancer (HNC) ...
... It has been reported that  p53 
An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma
An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma
Gong, Zhaojian; Yang, Qian; Zeng, Zhaoyang; Zhang, Wenling; Li, Xiayu; Zu, Xuyu; Deng, Hao; Chen, Pan; Liao, Qianjin; Xiang, Bo; Zhou, Ming; Li, Xiaoling; Li, Yong; Xiong, Wei; Li, Guiyuan
dysfunction is closely related to the ...
... are frequently affected in colorectal cancer is  p53 
Biological significance of promoter hypermethylation of p14/ARF gene: Relationships to p53 mutational status in Tunisian population with colorectal carcinoma
Biological significance of promoter hypermethylation of p14/ARF gene: Relationships to p53 mutational status in Tunisian population with colorectal carcinoma
Chaar, Ines; Amara, Sameh; Elamine, Olfa Elhadj; Khiari, Mariem; Ounissi, Donia; Khalfallah, Taher; Ben hmida, Abdelmajid; Mzabi, Sabeh; Bouraoui, Saadia
/ (MDM2)/p14ARF pathway. ...
... aspirin acetylated the tumor suppressor protein  p53 
Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53
Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53
Ai, Guoqiang; Dachineni, Rakesh; Kumar, D. Ramesh; Marimuthu, Srinivasan; Alfonso, Lloyd F.; Bhat, G. Jayarama
at lysine 382 in MDA-MB-231 human breast cancer ...
... The tumor suppressor  p53 
CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo
CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo
He, Xing-Xing; Zhang, Yu-Nan; Yan, Jun-Wei; Yan, Jing-Jun; Wu, Qian; Song, Yu-Hu
is one of the most frequently mutated genes in ...
... adenoma–carcinoma sequence, the complex K-ras/  p53 
Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort
Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort
Ines, Chaar; Donia, Ounissi; Rahma, Boughriba; Ammar, Azza Ben; Sameh, Amara; Khalfallah, Taher; Abdelmajid, Ben; Sabeh, Mzabi; Saadia, Bouraoui
mutation is one of the first alterations to occur ...
... The  p53 
Prognostic effect of p53 expression in patients with completely resected colorectal cancer
Prognostic effect of p53 expression in patients with completely resected colorectal cancer
Liu, Bin-Wei; Liu, Yang; Liu, Jun-Ru; Feng, Zhong-Xu; Liu, Tong
protein is closely involved in the carcinogenesis ...
... for clinicians to decide treatment options. High  p53 
Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis
Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis
Jiang, Liangdong; Tao, Cheng; He, Aiyong
expression has been implicated in tumor ...
... While  p53 
New insight on the biological role of p53 protein as a tumor suppressor: re-evaluation of its clinical significance in triple-negative breast cancer
New insight on the biological role of p53 protein as a tumor suppressor: re-evaluation of its clinical significance in triple-negative breast cancer
Jin, Min-Sun; Park, In Ae; Kim, Ji Young; Chung, Yul Ri; Im, Seock-Ah; Lee, Kyung-Hun; Moon, Hyeong-Gon; Han, Wonshik; Noh, Dong-Young; Ryu, Han Suk
mutation is found in the majority of ...
... of K-ras, APC (adenomatosis polyposis coli) and  p53 
Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians
Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians
Malhotra, Pooja; Anwar, Mumtaz; Nanda, Neha; Kochhar, Rakesh; Wig, Jai Dev; Vaiphei, Kim; Mahmood, Safrun
in tumor, adjoining and distant normal mucosa and ...
... Rescuing the function of mutant  p53 
CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo
CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo
He, Xingxing; Kong, Xinjuan; Yan, Junwei; Yan, Jingjun; Zhang, Yunan; Wu, Qian; Chang, Ying; Shang, Haitao; Dou, Qian; Song, Yuhu; Liu, Fang
protein is an attractive cancer therapeutic ...
... potency was mainly attributed to the induction of  p53 
Apoptosis induced by chamaejasmine in human osteosarcoma cells through p53 pathway
Apoptosis induced by chamaejasmine in human osteosarcoma cells through p53 pathway
Yang, Dawei; Wang, Peng; Ren, Xiaoping
. ...
... The  p53 
Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-analysis
Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-analysis
Wu, Bo; Guo, Dan; Guo, Ying
is a tumor suppressor gene which may be involved ...
... been investigated in mammalian cells that possess  p53 
RRP12 is a crucial nucleolar protein that regulates p53 activity in osteosarcoma cells
RRP12 is a crucial nucleolar protein that regulates p53 activity in osteosarcoma cells
Choi, Young Joon; Lee, Hye Won; Lee, Yun Sun; Shim, Da Mi; Seo, Sung Wook
, which has close functional association to ...
... assessing the prognostic role of upregulated  p53 
A systematic review of p53 as a biomarker of survival in patients with osteosarcoma
A systematic review of p53 as a biomarker of survival in patients with osteosarcoma
Fu, Hai-Liang; Shao, Lin; Wang, Qiang; Jia, Tao; Li, Ming; Yang, Da-Ping
in patients presenting osteosarcoma, and there is ...
... The tumor suppressor  p53 
Adenovirus type 12 E1B 55-kilodalton oncoprotein promotes p53-mediated apoptotic response of ovarian cancer to cisplatin
Adenovirus type 12 E1B 55-kilodalton oncoprotein promotes p53-mediated apoptotic response of ovarian cancer to cisplatin
Wang, Junnai; Gao, Qinglei; Li, Qiang
-mediated apoptotic response plays an important ...
... study has indicated that knockdown of human  p53 
p53 suppresses CCL2-induced subcutaneous tumor xenograft
p53 suppresses CCL2-induced subcutaneous tumor xenograft
Tang, Xiaoren; Amar, Salomon
has a strong negative impact on CCL2 induction. ...
... case–control study investigated the mutations in  p53 
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China
Chen, Han-chun; Chen, Hui-juan; Khan, Md. Asaduzzaman; Rao, Zhou-zhou; Wan, Xin-xing; Tan, Bo; Zhang, Dian-zheng
and k-ras genes of 123 gastric carcinoma patients ...
...  p53 
Expression of p53 family genes in urinary bladder cancer: correlation with disease aggressiveness and recurrence
Expression of p53 family genes in urinary bladder cancer: correlation with disease aggressiveness and recurrence
Papadogianni, Danae; Soulitzis, Nikolaos; Delakas, Demetrios; Spandidos, Demetrios A.
is a tumour suppressor gene with an established ...
... features. The tumor suppressor protein  p53 
The p53-independent induction of apoptosis in breast cancer cells in response to proteasome inhibitor bortezomib
The p53-independent induction of apoptosis in breast cancer cells in response to proteasome inhibitor bortezomib
Yerlikaya, Azmi; Okur, Emrah; Ulukaya, Engin
is a critical regulator of apoptosis in many cell ...
... The  p53 
Interaction between p53 codon 72 and MDM2 309T>G polymorphisms and the risk of hepatocellular carcinoma
Interaction between p53 codon 72 and MDM2 309T>G polymorphisms and the risk of hepatocellular carcinoma
Qiu, Moqin; Liu, Yingchun; Yu, Xiangyuan; Qin, Linyuan; Bei, Chunhua; Zeng, Xiaoyun; Qiu, Xiaoqiang; Tang, Bo; He, Songqing; Yu, Hongping
tumor suppressor and its negative regulator, ...
... The  P53 
Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk
Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk
Cai, Kemin; Wang, Yu; Zhao, Xiaojun; Bao, Xueli
codon 72 polymorphism has been identified as a ...

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