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... Background MCT-1 oncoprotein accelerates  p53 
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Kasiappan, Ravi; Shih, Hung-Ju; Wu, Meng-Hsun; Choy, ChikOn; Lin, Tai-Du; Chen, Linyi; Hsu, Hsin-Ling
protein degradation via a proteosome pathway. ...
... Background  p53 
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Zhang, Lili; Nie, Linghu; Maki, Carl G
is a tumor suppressor and potent inhibitor of ...
... Background Activation of  p53 
HIPK2 modulates p53 activity towards pro-apoptotic transcription
HIPK2 modulates p53 activity towards pro-apoptotic transcription
Puca, Rosa; Nardinocchi, Lavinia; Sacchi, Ada; Rechavi, Gideon; Givol, David; D'Orazi, Gabriella
-mediated gene transcription is a critical ...
... as well as induction of apoptosis through  p53 
PTTG/securin activates expression of p53 and modulates its function
PTTG/securin activates expression of p53 and modulates its function
Hamid, Tariq; Kakar, Sham S
-dependent and ...
... Background  p53 
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Ajay, Amrendra K; Upadhyay, Ankur K; Singh, Sandeep; Vijayakumar, Maleppillil V; Kumari, Ratna; Pandey, Vimal; Boppana, Ramanamurthy; Bhat, Manoj K
is the most studied tumor suppressor and its ...
... that can restore biological activity of mutant  p53 
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Knowell, Ashley E; Patel, Divya; Morton, Derrick J; Sharma, Pankaj; Glymph, Shanora; Chaudhary, Jaideep
are an area of high interest given that mutant ...
... the second as backup. Not necessarily so with  p53 
Resistance of mitochondrial p53 to dominant inhibition
Resistance of mitochondrial p53 to dominant inhibition
Heyne, Kristina; Schmitt, Katrin; Mueller, Daniel; Armbruester, Vivienne; Mestres, Pedro; Roemer, Klaus
. ...
... in breast cancer, we identified IBP was a novel  p53 
Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells
Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells
Yang, Mingzhen; Yuan, Fang; Li, Peng; Chen, Zhongjiao; Chen, An; Li, Shuhui; Hu, Chuanmin
target gene. ...
... The prevalence in human cancers of mutations in  p53 
GSK3β N-terminus binding to p53 promotes its acetylation
GSK3β N-terminus binding to p53 promotes its acetylation
Eom, Tae-Yeon; Jope, Richard S
exemplifies its crucial role as a tumor ...
... Mutational inactivation of the tumour suppressor  p53 
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
Kang, Khong Bee; Zhu, Congju; Yong, Sook Kwin; Gao, Qiuhan; Wong, Meng Cheong
gene is frequent in malignant gliomas. ...
... Background The tumor suppressor gene  p53 
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Baumbusch, Lars O; Myhre, Simen; Langerød, Anita; Bergamaschi, Anna; Geisler, Stephanie B; Lønning, Per E; Deppert, Wolfgang; Dornreiter, Irene; Børresen-Dale, Anne-Lise
(TP53) controls numerous signaling pathways and ...
... 50% of all human cancers the tumor suppressor  p53 
Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts
Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts
Lenos, Kristiaan; de Lange, Job; Teunisse, Amina FAS; Lodder, Kirsten; Verlaan-de Vries, Matty; Wiercinska, Eliza; van der Burg, Marja JM; Szuhai, Karoly; Jochemsen, Aart G
is mutated. ...
... Background  p53 
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
Dong, Peixin; Xu, Zhujie; Jia, Nan; Li, Dajin; Feng, Youji
is the most commonly mutated tumor suppressor ...
... of the MCP-1 upstream region proposed a putative  p53 
Regulation of MCP-1 chemokine transcription by p53
Regulation of MCP-1 chemokine transcription by p53
Hacke, Katrin; Rincon-Orozco, Bladimiro; Buchwalter, Gilles; Siehler, Simone Y.; Wasylyk, Bohdan; Wiesmüller, Lisa; Rösl, Frank
binding side about 2.5 kb upstream of the ...
... antagonist nutlin-3 has proved to be an effective  p53 
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
Haaland, Ingvild; Opsahl, Jill A; Berven, Frode S; Reikvam, Håkon; Fredly, Hanne K; Haugse, Ragnhild; Thiede, Bernd; McCormack, Emmet; Lain, Sonia; Bruserud, Øystein; Gjertsen, Bjørn Tore
activating therapeutic compound in several ...
... the mitotic function of Survivin is linked to  p53 
Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53
Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53
Wiedemuth, Ralf; Klink, Barbara; Töpfer, Katrin; Schröck, Evelin; Schackert, Gabriele; Tatsuka, Masaaki; Temme, Achim
-mediated G1 cell cycle arrest and affects ...
... that govern cell survival. It phosphorylates  p53 
Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma
Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma
Liu, Qingjun; Mier, James W; Panka, David J
, for example, and induces its nuclear export, ...
... different in the lung cancer cell lines H1299 (  p53 
Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent
Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent
Puliyappadamba, Vineshkumar T; Cheriyan, Vino T; Thulasidasan, Arun Kumar T; Bava, Smitha V; Vinod, Balachandran S; Prabhu, Priya R; Varghese, Ranji; Bevin, Arathy; Venugopal, Shalini; Anto, Ruby John
-/-) and A549 ( ...
... Frequent mutations of  p53 
FATS is a transcriptional target of p53 and associated with antitumor activity
FATS is a transcriptional target of p53 and associated with antitumor activity
Zhang, Xifeng; Zhang, Qian; Zhang, Jun; Qiu, Li; Yan, Shuang-shuang; Feng, Juling; Sun, Yan; Huang, Xingxu; Lu, Karen H; Li, Zheng
in human cancers exemplify its crucial role as a ...
... Bid. However, the role of caspase-8 in  p53 
Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells
Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells
Liu, Juan; Uematsu, Hiroshi; Tsuchida, Nobuo; Ikeda, Masa-Aki
- and p73-dependent apoptosis induced by ...
... Previous studies revealed that UV-damage induced  p53 
ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation
ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation
Craig, Ashley L; Holcakova, Jitka; Finlan, Lee E; Nekulova, Marta; Hrstka, Roman; Gueven, Nuri; DiRenzo, James; Smith, Graeme; Hupp, Ted R; Vojtesek, Borivoj
phosphorylation is confined to ΔNp63α-positive ...
... how MYC and PAX3-FKHR oncogenes influenced  p53 
Differential cooperation of oncogenes with p53 and Bax to induce apoptosis in rhabdomyosarcoma
Differential cooperation of oncogenes with p53 and Bax to induce apoptosis in rhabdomyosarcoma
Taylor, Alan C; Schuster, Katja; McKenzie, Pamela P; Harris, Linda C
-mediated apoptosis, rhabdomyosarcoma cells were ...
... Recent whole-exome sequencing identified  p53 
Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma
Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma
Kong, Bo; Cheng, Tao; Qian, Chengjia; Wu, Weiwei; Steiger, Katja; Cao, Jing; Schlitter, Anna Melissa; Regel, Ivonne; Raulefs, Susanne; Friess, Helmut; Erkan, Mert; Esposito, Irene; Kleeff, Jörg; Michalski, Christoph W.
mutations in a subset of human ACC. ...
... the protein expression of Chmp1A, CRBP-1,  P53 
Chmp 1A is a mediator of the anti-proliferative effects of All-trans Retinoic Acid in human pancreatic cancer cells
Chmp 1A is a mediator of the anti-proliferative effects of All-trans Retinoic Acid in human pancreatic cancer cells
Li, Jing; Orr, Brandon; White, Kayla; Belogortseva, Natalia; Niles, Richard; Boskovic, Goran; Nguyen, Hanh; Dykes, Ava; Park, Maiyon
and phospho- ...
... mediators of cellular stress responses, namely  p53 
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
Obacz, Joanna; Pastorekova, Silvia; Vojtesek, Borek; Hrstka, Roman
and HIF, which significantly affect cancer ...

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