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... reactivity against the tumor suppressor protein  p53 
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
Met, Özcan; Balslev, Eva; Flyger, Henrik; Svane, Inge Marie
in breast cancer patients (BCP) at the time point ...
... poorly known. We identify the presence of three  p53 
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Kelkar, Madhura G.; Thakur, Bhushan; Derle, Abhishek; Chatterjee, Sushmita; Ray, Pritha; De, Abhijit
binding sites on the human NIS promoter sequence ...
... factors, which promote S-phase entry,  p53 
αB-Crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation
αB-Crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation
Petrovic, Vladimir; Malin, Dmitry; Cryns, Vincent L.
-dependent and ...
... parameters of poor prognosis such as tumor grade,  p53 
Abstract
Abstract
expression and Ki67 proliferation index. ...
... Mutations in the  p53 
Adiposity is associated with p53 gene mutations in breast cancer
Adiposity is associated with p53 gene mutations in breast cancer
Ochs-Balcom, Heather M.; Marian, Catalin; Nie, Jing; Brasky, Theodore M.; Goerlitz, David S.; Trevisan, Maurizio; Edge, Stephen B.; Winston, Janet; Berry, Deborah L.; Kallakury, Bhaskar V.; Freudenheim, Jo L.; Shields, Peter G.
gene are among the most frequent genetic events ...
... identified a putative response element for the  p53 
Induction of the small heat shock protein αB-crystallin by genotoxic stress is mediated by p53 and p73
Induction of the small heat shock protein αB-crystallin by genotoxic stress is mediated by p53 and p73
Evans, Joseph R.; Bosman, Joshua D.; Brown-Endres, Lauren; Yehiely, Fruma; Cryns, Vincent L.
tumor suppressor protein. ...
... Most tumor cells due to disruptions in the  p53 
Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling
Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling
Thomas, Christoforos G.; Strom, Anders; Lindberg, Karolina; Gustafsson, Jan-Ake
-dependent G1 pathway are dependent on S-phase ...
... Inactivation of tumor suppressor  p53 
Disruption of estrogen receptor α-p53 interaction in breast tumors: a novel mechanism underlying the anti-tumor effect of radiation therapy
Disruption of estrogen receptor α-p53 interaction in breast tumors: a novel mechanism underlying the anti-tumor effect of radiation therapy
Liu, Wensheng; Ip, Margot M.; Podgorsak, Matthew B.; Das, Gokul M.
is one of the most frequent events in cancer. ...
... elicited by viral oncogenes that abrogate the  p53 
Abstract
Abstract
and pRb tumor suppressors (Hanahan, 1985; Arbeit ...
... to antiestrogen therapy and have wild-type  p53 
P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis
P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis
Fuchs-Young, Robin; Shirley, Stephanie H.; Lambertz, Isabel; Colby, Jennifer K. L.; Tian, Jie; Johnston, Dennis; Gimenez-Conti, Irma B.; Donehower, Lawrence A.; Conti, Claudio J.; Hursting, Stephen D.
. ...
... survival. The tumor suppressor TP53 encodes the  p53 
Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines
Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines
Fernández-Cuesta, Lynnette; Anaganti, Suresh; Hainaut, Pierre; Olivier, Magali
protein, an important mediator of the ...
... line mutations in the tumor suppressor gene,  p53 
Identification and characterization of two novel germ line p53 mutations in the non-LFS/non-LFL breast cancer families in Chinese population
Identification and characterization of two novel germ line p53 mutations in the non-LFS/non-LFL breast cancer families in Chinese population
Cao, A-Yong; Jin, Wei; Shi, Peng-Cheng; Di, Gen-hong; Shen, Zhen-Zhou; Shao, Zhi-Ming
, are known to cause Li-Fraumeni syndrome (LFS) ...
... The  p53 
Wild-type p53 inhibits pro-invasive properties of TGF-β3 in breast cancer, in part through regulation of EPHB2, a new TGF-β target gene
Wild-type p53 inhibits pro-invasive properties of TGF-β3 in breast cancer, in part through regulation of EPHB2, a new TGF-β target gene
Lam, Suzanne; Wiercinska, Eliza; Teunisse, Amina F. A. S.; Lodder, Kirsten; ten Dijke, Peter; Jochemsen, Aart G.
tumor suppressor protein is primarily known for ...
... to evaluate the difference in outcomes based on  p53 
Overexpression of p53 is correlated with poor outcome in premenopausal women with breast cancer treated with tamoxifen after chemotherapy
Overexpression of p53 is correlated with poor outcome in premenopausal women with breast cancer treated with tamoxifen after chemotherapy
Kim, Hee Sung; Yom, Cha Kyong; Kim, Hee Jeong; Lee, Jong Won; Sohn, Jin Hee; Kim, Jun Ho; Park, Yong Lai; Ahn, Sei Hyun
overexpression of patients with breast cancer who ...
... factor-κB (NF-κB) was augmented, while those of  p53 
Id-1 regulates Bcl-2 and Bax expression through p53 and NF-κB in MCF-7 breast cancer cells
Id-1 regulates Bcl-2 and Bax expression through p53 and NF-κB in MCF-7 breast cancer cells
Kim, Hwan; Chung, Heekyoung; Kim, Hyun-Jun; Lee, Jeong-Yeon; Oh, Mi-Yun; Kim, Yongseok; Kong, Gu
and IκB were reduced. ...
... effects of metformin in cancer cells.  p53 
Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells
Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells
Pandiri, Indira; Chen, Yingqing; Joe, Yeonsoo; Kim, Hyo Jeong; Park, Jeongmin; Chung, Hun Taeg; Park, Jeong Woo
wild-type and ...
... immunohistochemically stained for expression of  p53 
The prognostic value of apoptotic and proliferative markers in breast cancer
The prognostic value of apoptotic and proliferative markers in breast cancer
Engels, Charla C.; Ruberta, Francesca; Kruijf, Esther M.; Pelt, Gabi W.; Smit, Vincent T. H. B. M.; Liefers, Gerrit Jan; Matsushima, Tomoko; Shibayama, Masaki; Ishihara, Hideki; Velde, Cornelis J. H.; Kuppen, Peter J. K.
, active-caspase-3, and Ki67. ...
... phenotypes in MCF10A cells. We further show that  p53 
The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasion
The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasion
Kim, Eun-Sook; Jeong, Jae-Boon; Kim, Seonhoe; Lee, Kyung-Min; Ko, Eunyoung; Noh, Dong-Young; Hwang, Ki-Tae; Ha, Ji Hee; Lee, Chang Ho; Kim, Sang Geon; Moon, Aree
is an important transcription factor for ...
... The oncoprotein MDM4 plays an essential role in  P53 
Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility
Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility
Liu, Jibing; Tang, Xiaohu; Li, Meng; Lu, Chao; Shi, Juan; Zhou, Liqing; Yuan, Qipeng; Yang, Ming
tumor suppressor pathway through negative ...
... as highly sensitive to AMG 900. AMG 900 induced  p53 
AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53
AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53
Kalous, Ondrej; Conklin, Dylan; Desai, Amrita J.; Dering, Judy; Goldstein, Jennifer; Ginther, Charles; Anderson, Lee; Lu, Ming; Kolarova, Teodora; Eckardt, Mark A.; Langerød, Anita; Børresen-Dale, Anne-Lise; Slamon, Dennis J.; Finn, Richard S.
and p21 protein expression in cell lines with wt ...
... analysis, ATM loss combined with abnormal  p53 
Loss of ataxia-telangiectasia-mutated protein expression correlates with poor prognosis but benefits from anthracycline-containing adjuvant chemotherapy in breast cancer
Loss of ataxia-telangiectasia-mutated protein expression correlates with poor prognosis but benefits from anthracycline-containing adjuvant chemotherapy in breast cancer
Suh, Koung Jin; Ryu, Han Suk; Lee, Kyung-Hun; Kim, Hyojin; Min, Ahrum; Kim, Tae-Yong; Yang, Yaewon; Moon, Hyeong-Gon; Han, Sae-Won; Oh, Do-Youn; Han, Wonshik; Park, In Ae; Noh, Dong-Young; Im, Seock-Ah
expression was an independent predictor of ...
... regulate apoptosis through phosphorylation of  p53 
Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines
Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines
Wasielewski, Marijke; Hanifi-Moghaddam, Pejman; Hollestelle, Antoinette; Merajver, Sofia D.; Ouweland, Ans; Klijn, Jan G. M.; Ethier, Stephen P.; Schutte, Mieke
[1, 2]. ...
... deleterious germline mutations in both BRCA1 and  p53 
Double heterozygosity for germline mutations in BRCA1 and p53 in a woman with early onset breast cancer
Double heterozygosity for germline mutations in BRCA1 and p53 in a woman with early onset breast cancer
Bell, K.; Hodgson, N.; Levine, M.; Sadikovic, B.; Zbuk, K.
. ...
... in highly metastatic cells with impaired  p53 
NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics
NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics
Ostrakhovitch, Elena A.; Li, Shawn S. C.
functions linking the expression of DUOXA1 with ...
... ERβ and psoriasin/S100A7 was observed in the  p53 
Estrogen receptor-β regulates psoriasin (S100A7) in human breast cancer
Estrogen receptor-β regulates psoriasin (S100A7) in human breast cancer
Skliris, George P.; Lewis, Anthony; Emberley, Ethan; Peng, Baocheng; Weebadda, Wineeta K.; Kemp, Angela; Davie, James R.; Shiu, Robert P. C.; Watson, Peter H.; Murphy, Leigh C.
immunohistochemically negative subset of invasive ...

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