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... no curative treatments. While mutation of the  P53 
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
Avery-Kiejda, Kelly A; Bowden, Nikola A; Croft, Amanda J; Scurr, Lyndee L; Kairupan, Carla F; Ashton, Katie A; Talseth-Palmer, Bente A; Rizos, Helen; Zhang, Xu D; Scott, Rodney J; Hersey, Peter
tumour suppressor gene is a common feature of ...
... Methods We performed computer modeling of the  p53 
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Golubovskaya, Vita M; Ho, Baotran; Zheng, Min; Magis, Andrew; Ostrov, David; Morrison, Carl; Cance, William G
peptide containing the site of interaction with ...
... Background The tumor suppressor  p53 
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Bisio, Alessandra; De Sanctis, Veronica; Del Vescovo, Valerio; Denti, Michela A; Jegga, Anil G; Inga, Alberto; Ciribilli, Yari
is a sequence-specific transcription factor that ...
... the function of tumor suppressor protein  p53 
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Dixit, Updesh; Liu, Zhihe; Pandey, Ashutosh K; Kothari, Ramesh; Pandey, Virendra N
. ...
... One of the key regulators of the DDR is  p53 
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
Valentine, Jane M; Kumar, Sonia; Moumen, Abdeladim
, itself tightly regulated by MDM2. ...
... conventional treatments and is often defective in  p53 
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
Shimazu, Kengo; Tada, Yuji; Morinaga, Takao; Shingyoji, Masato; Sekine, Ikuo; Shimada, Hideaki; Hiroshima, Kenzo; Namiki, Takao; Tatsumi, Koichiro; Tagawa, Masatoshi
pathways. ...
... Background The  p53 
Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
Hafsi, Hind; Santos-Silva, Daniela; Courtois-Cox, Stéphanie; Hainaut, Pierre
protein is expressed as multiple isoforms that ...
... defects. Mutations in the tumor suppressor  p53 
Gene expression patterns associated with p53 status in breast cancer
Gene expression patterns associated with p53 status in breast cancer
Troester, Melissa A; Herschkowitz, Jason I; Oh, Daniel S; He, Xiaping; Hoadley, Katherine A; Barbier, Claire S; Perou, Charles M
occur more frequently in estrogen receptor (ER) ...
... (NSCLC). Gene copy number was analyzed by qPCR.  P53 
P53 suppresses expression of the 14-3-3gamma oncogene
P53 suppresses expression of the 14-3-3gamma oncogene
Radhakrishnan, Vijayababu M; Putnam, Charles W; Qi, Wenqing; Martinez, Jesse D
mutations were detected by direct sequencing and ...
... Background  p53 
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine
Reed, Karen R; Meniel, Valerie S; Marsh, Victoria; Cole, Alicia; Sansom, Owen J; Clarke, Alan R
is an important tumour suppressor with a known ...
... growth factor (VEGF) and the tumor suppressor  p53 
Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features
Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features
Feng, Chang Wei; Wang, Li Dong; Jiao, Lian Hua; Liu, Bin; Zheng, Shu; Xie, Xin Ji
are fundamental play-markers of the angiogenic ...
... million deaths each year worldwide and protein  p53 
The role of circulating anti-p53 antibodies in patients with advanced non-small cell lung cancer and their correlation to clinical parameters and survival
The role of circulating anti-p53 antibodies in patients with advanced non-small cell lung cancer and their correlation to clinical parameters and survival
Bergqvist, Michael; Brattström, Daniel; Larsson, Anders; Hesselius, Patrik; Brodin, Ola; Wagenius, Gunnar
has been shown to be involved in the intricate ...
... Background The  p53 
Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia
Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia
Terry, Mary Beth; Neugut, Alfred I; Mansukhani, Mahesh; Waye, Jerome; Harpaz, Noam; Hibshoosh, Hanina
tumor suppressor gene is commonly mutated in ...
... of the determinants of impaired chemosensitivity.  p53 
Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?
Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?
Osumi, Hiroki; Shinozaki, Eiji; Suenaga, Mitsukuni; Kumekawa, Yosuke; Ogura, Mariko; Ozaka, Masato; Matsusaka, Satoshi; Chin, Keisho; Yamamoto, Noriko; Mizunuma, Nobuyuki
is a tumor-suppressor protein in humans encoded ...
... we compared aCGH data from 130 mouse Brca1 Δ/Δ ;  p53 
Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers
Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers
Holstege, Henne; van Beers, Erik; Velds, Arno; Liu, Xiaoling; Joosse, Simon A; Klarenbeek, Sjoerd; Schut, Eva; Kerkhoven, Ron; Klijn, Christiaan N; Wessels, Lodewyk FA; Nederlof, Petra M; Jonkers, Jos
Δ/Δ , Brca2 Δ/Δ ; ...
... activation was associated with stabilization of  p53 
Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells
Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells
Verma, Suman; Tabb, Michelle M; Blumberg, Bruce
and up-regulation of cell cycle regulatory and ...
... focuses on the DNA damage pathway to induce a  p53 
The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status
The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status
Turinetto, Valentina; Porcedda, Paola; Orlando, Luca; De Marchi, Mario; Amoroso, Antonio; Giachino, Claudia
-mediated cellular response leading to either G1 ...
... transduction. Furthermore, a role of the  p53 
Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression
Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression
Yang, Shan; Kawamura, Kiyoko; Okamoto, Shinya; Yamauchi, Suguru; Shingyoji, Masato; Sekine, Ikuo; Kobayashi, Hiroshi; Tada, Yuji; Tatsumi, Koichiro; Hiroshima, Kenzo; Shimada, Hideaki; Tagawa, Masatoshi
pathways in cytotoxicity mediated by ...
... Protein 53) gene can lead to expression of mutant  p53 
Prognostic role of serum p53 antibodies in lung cancer
Prognostic role of serum p53 antibodies in lung cancer
Mattioni, Manlio; Soddu, Silvia; Prodosmo, Andrea; Visca, Paolo; Conti, Salvatore; Alessandrini, Gabriele; Facciolo, Francesco; Strigari, Lidia
proteins that accumulate in cancer cells and can ...
... apoptosis was linked with phosphorylation of  p53 
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
Shi, Yan; Sahu, Ravi P; Srivastava, Sanjay K
at Ser-15 and ERK at Thr-202/Tyr-204 in Capan-2 ...
... published data showed discrepancies beteween  P53 
cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer
cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer
Szybka, Malgorzata; Zakrzewska, Magdalena; Rieske, Piotr; Pasz-Walczak, Grazyna; Kulczycka-Wojdala, Dominika; Zawlik, Izabela; Stawski, Robert; Jesionek-Kupnicka, Dorota; Liberski, Pawel P; Kordek, Radzislaw
cDNA and DNA sequencing in glioblastomas. ...
... signal in cells. There are two reported  p53 
Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation
Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation
Hanafusa, Tadashi; Shinji, Toshiyuki; Shiraha, Hidenori; Nouso, Kazuhiro; Iwasaki, Yoshiaki; Yumoto, Eichiro; Ono, Toshiro; Koide, Norio
regulatory regions in the IGFBP3 gene; one ...
... Background  P53 
Prognostic significance of anti-p53 and anti-KRas circulating antibodies in esophageal cancer patients treated with chemoradiotherapy
Prognostic significance of anti-p53 and anti-KRas circulating antibodies in esophageal cancer patients treated with chemoradiotherapy
Blanchard, Pierre; Quero, Laurent; Pacault, Vincent; Schlageter, Marie-Helene; Baruch-Hennequin, Valerie; Hennequin, Christophe
mutations are an adverse prognostic factor in ...
... showed that NAT10 acetylates the tumor suppressor  p53 
NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity
NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity
Li, Qijiong; Liu, Xiaofeng; Jin, Kemin; Lu, Min; Zhang, Chunfeng; Du, Xiaojuan; Xing, Baocai
and regulates ...
... Background  p53 
Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer
Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer
Fariña Sarasqueta, Arantza; Forte, Giusi Irma; Corver, Wim E; de Miranda, Noel F; Ruano, Dina; van Eijk, Ronald; Oosting, Jan; Tollenaar, Rob AEM; van Wezel, Tom; Morreau, Hans
(encoded by TP53) is involved in DNA damage ...

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