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... In this work we present evidence that the  p53 
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Dreyfus, David H; Nagasawa, Masayuki; Gelfand, Erwin W; Ghoda, Lucy Y
tumor suppressor protein and NF-κB transcription ...
... Understanding the mechanism underlying  p53 
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... in the genesis and progression of cancer, mutant  p53 
Mutant p53 and the Response to Chemotherapy and Radiation
Mutant p53 and the Response to Chemotherapy and Radiation
Tchelebi, Leila; Ashamalla, Hani; Graves, Paul R.
also appears to play a significant role in the ...
... tumor suppressor in multicellular organisms,  p53 
p53
p53
Menendez, Daniel; Nguyen, Thuy-Ai; Resnick, Michael A.; Anderson, Carl W.
is one of the most intensively studied human ...
... Methods We performed computer modeling of the  p53 
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Golubovskaya, Vita M; Ho, Baotran; Zheng, Min; Magis, Andrew; Ostrov, David; Morrison, Carl; Cance, William G
peptide containing the site of interaction with ...
... Most tumors inactivate the  p53 
Mutant p53-Driven Tumorigenesis
Mutant p53-Driven Tumorigenesis
Terzian, Tamara; Lozano, Guillermina
tumor suppressor pathway via single nucleotide ...
... in each subtype, alterations of tumor suppressor  p53 
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
England, Bryant; Huang, Tiangui; Karsy, Michael
are the most common, seen in 25–30 % of primary ...
... Loss of function of  p53 
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Yu, Xin; Narayanan, Sumana; Vazquez, Alexei; Carpizo, Darren R.
, either through mutations in the gene or through ...
... Background  p53 
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
Brynczka, Christopher; Labhart, Paul; Merrick, B Alex
is recognized as a critical regulator of the cell ...
... Background The tumor suppressor protein  p53 
p53 induces distinct epigenetic states at its direct target promoters
p53 induces distinct epigenetic states at its direct target promoters
Vrba, Lukas; Junk, Damian J; Novak, Petr; Futscher, Bernard W
is a transcription factor that is mutated in many ...
... Background PNC-27 and PNC-28 are  p53 
The Penetratin Sequence in the Anticancer PNC-28 Peptide Causes Tumor Cell Necrosis Rather Than Apoptosis of Human Pancreatic Cancer Cells
The Penetratin Sequence in the Anticancer PNC-28 Peptide Causes Tumor Cell Necrosis Rather Than Apoptosis of Human Pancreatic Cancer Cells
Bowne, Wilbur B.; Sookraj, Kelley A.; Vishnevetsky, Michael; Adler, Victor; Sarafraz-Yazdi, Ehsan; Lou, Sunming; Koenke, Jesco; Shteyler, Vadim; Ikram, Kamran; Harding, Michael; Bluth, Martin H.; Ng, Mou; Brandt-Rauf, Paul W.; Hannan, Raqibul; Bradu, Stephan; Zenilman, Michael E.; Michl, Josef; Pincus, Matthew R.
-derived peptides from the human double minute ...
... The tumor suppressor  p53 
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Zhang, Qi; Zeng, Shelya X.; Lu, Hua
plays a central role in anti-tumorigenesis and ...
... point mutation of TP53 or through disruption of  p53 
p53 in Head and Neck Cancer
p53 in Head and Neck Cancer
Roh, Jong-Lyel; Koch, Wayne M.
protein function as a consequence of oncogenic ...
... Background The  p53 
Impact of Alu repeats on the evolution of human p53 binding sites
Impact of Alu repeats on the evolution of human p53 binding sites
Cui, Feng; Sirotin, Michael V; Zhurkin, Victor B
tumor suppressor protein is involved in a ...
...  p53 
Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
Regeling, Anouk; Armata, Heather L.; Gallant, Judy; Jones, Stephen N.; Sluss, Hayla K.
is a major suppressor of human malignancy. ...
... The human mutant  p53 
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Duan, Wenrui; Gao, Li; Jin, David; Otterson, Gregory A.; Villalona-Calero, Miguel A.
(273H) has been shown in vitro to have both ...
... Background The master regulator  p53 
Dissecting microregulation of a master regulatory network
Dissecting microregulation of a master regulatory network
Sinha, Amit U; Kaimal, Vivek; Chen, Jing; Jegga, Anil G
tumor-suppressor protein through coordination of ...
... cells. HCT 116 colorectal cancer cells expressing  p53 
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Beaino, Wissam; Guo, Yunjun; Chang, Albert J.; Anderson, Carolyn J.
(+/+) and not expressing ...
... Abstract Background The  p53 
Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
Huang, Vera; Lu, Xin; Jiang, Yong; Wang, Jean YJ
tumor suppressor and its related protein, p73, ...
... the wild-type (wt) form of the tumor suppressor  p53 
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
Wang, Fei; Liu, Jianfeng; Robbins, Delira; Morris, Kerri; Sit, Amos; Liu, Yong-Yu; Zhao, Yunfeng
, can translocate to mitochondria due to ...
... oxygen species during wound repair responses.  p53 
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
Mizuguchi, Yoshiaki; Specht, Susan; Lunz, John G, III; Isse, Kumiko; Corbitt, Natasha; Takizawa, Toshihiro; Demetris, Anthony J
is also widely recognized as the node in cellular ...
... defects. Mutations in the tumor suppressor  p53 
Gene expression patterns associated with p53 status in breast cancer
Gene expression patterns associated with p53 status in breast cancer
Troester, Melissa A; Herschkowitz, Jason I; Oh, Daniel S; He, Xiaping; Hoadley, Katherine A; Barbier, Claire S; Perou, Charles M
occur more frequently in estrogen receptor (ER) ...
... anti-inflammatory drug (NSAID) use varied by  P53 
Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
Figueroa, Jonine D.; Terry, Mary Beth; Gammon, Marilie D.; Vaughan, Thomas L.; Risch, Harvey A.; Zhang, Fang-Fang; Kleiner, David E.; Bennett, William P.; Howe, Christine L.; Dubrow, Robert; Mayne, Susan T.; Fraumeni, Joseph F., Jr.; Chow, Wong-Ho
overexpression. ...
... tumor suppressor in multicellular organisms,  p53 
p53
p53
Alexieva-Botcheva, Krassimira; Anderson, Carl W.
arguably is one of the most intensively studied ...
... Mutations in the TP53 gene or the  p53 
p53 Pathway Alterations in Brain Tumors
p53 Pathway Alterations in Brain Tumors
Yin, Shaoman; Van Meir, Erwin G.
pathway are required for the formation of many ...

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