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... a variety of human cancers containing the mutant  p53 
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism
Hori, Makoto; Suzuki, Keiji; Udono, Masako U.; Yamauchi, Motohiro; Mine, Mariko; Watanabe, Masami; Kondo, Shigeo; Hozumi, Yutaka
(mt- ...
... In this work we present evidence that the  p53 
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Dreyfus, David H; Nagasawa, Masayuki; Gelfand, Erwin W; Ghoda, Lucy Y
tumor suppressor protein and NF-κB transcription ...
... conventional treatments and is often defective in  p53 
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
Shimazu, Kengo; Tada, Yuji; Morinaga, Takao; Shingyoji, Masato; Sekine, Ikuo; Shimada, Hideaki; Hiroshima, Kenzo; Namiki, Takao; Tatsumi, Koichiro; Tagawa, Masatoshi
pathways. ...
... Understanding the mechanism underlying  p53 
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... fate. Mutations within the TP53 (tumor suppressor  p53 
p53 regulates cytoskeleton remodeling to suppress tumor progression
p53 regulates cytoskeleton remodeling to suppress tumor progression
Araki, Keigo; Ebata, Takahiro; Guo, Alvin Kunyao; Tobiume, Kei; Wolf, Steven John; Kawauchi, Keiko
) gene leading to loss or gain of function (GOF) ...
... The tumor suppressor  p53 
The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage
The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage
Masuda, Yoshiko; Futamura, Manabu; Kamino, Hiroki; Nakamura, Yasuyuki; Kitamura, Noriaki; Ohnishi, Shiho; Miyamoto, Yuji; Ichikawa, Hitoshi; Ohta, Tsutomu; Ohki, Misao; Kiyono, Tohru; Egami, Hiroshi; Baba, Hideo; Arakawa, Hirofumi
plays a crucial role in the cellular response to ...
... we generated a series of Atm +/- mice on the  p53 
Atm heterozygous deficiency enhances development of mammary carcinomas in p53heterozygous knockout mice
Atm heterozygous deficiency enhances development of mammary carcinomas in p53heterozygous knockout mice
Umesako, Seiichi; Fujisawa, Kae; Iiga, Sayoko; Mori, Nobuko; Takahashi, Masahiro; Hong, Doo-Pyo; Song, Chang-Woo; Haga, Satomi; Imai, Syunsuke; Niwa, Otsura; Okumoto, Masaaki
+/- background with a certain predisposition to ...
... transduction. Furthermore, a role of the  p53 
Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression
Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression
Yang, Shan; Kawamura, Kiyoko; Okamoto, Shinya; Yamauchi, Suguru; Shingyoji, Masato; Sekine, Ikuo; Kobayashi, Hiroshi; Tada, Yuji; Tatsumi, Koichiro; Hiroshima, Kenzo; Shimada, Hideaki; Tagawa, Masatoshi
pathways in cytotoxicity mediated by ...
... To further elucidate the significance of  p53 
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Feng, Yu-Zhen; Shiozawa, Tanri; Horiuchi, Akiko; Shih, Hsien-Chang; Miyamoto, Tsutomu; Kashima, Hiroyasu; Suzuki, Akihisa; Nikaido, Toshio; Konishi, Ikuo
mutation in endometrial carcinoma, we ...
... is the multifunctional transcription factor  p53 
p53 Replacement Therapy for Cancer
p53 Replacement Therapy for Cancer
Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi
gene that regulates diverse cellular phenomena ...
... studies have shown that aberrant activation of  p53 
Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis
Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis
Ishimura, Akihiko; Terashima, Minoru; Tange, Shoichiro; Suzuki, Takeshi
signaling leads to embryonic lethality. ...
... using a tissue array. Immunoreactivities of CHC,  p53 
Clathrin heavy chain is a useful immunohistochemical marker for esophageal squamous intraepithelial neoplasia
Clathrin heavy chain is a useful immunohistochemical marker for esophageal squamous intraepithelial neoplasia
Tokita, Kazuya; Seimiya, Masanori; Matsushita, Kazuyuki; Tomonaga, Takeshi; Onodera, Kiyotaka; Ohki, Syoji; Tanizawa, Tohru; Uesato, Masaya; Shimada, Hideaki; Matsubara, Hisahiro; Nakatani, Yukio; Nomura, Fumio
, and Ki67 were then compared in 44 ...
... In order to categorize chemicals, we used  p53 
Gene-modified embryonic stem cell test to characterize chemical risks
Gene-modified embryonic stem cell test to characterize chemical risks
Kitada, Kohei; Kizu, Akane; Teramura, Takeshi; Takehara, Toshiyuki; Hayashi, Masami; Tachibana, Daisuke; Wanibuchi, Hideki; Fukushima, Shoji; Koyama, Masayasu; Yoshida, Kayo; Morita, Takashi
gene-modified mouse ES cells as well as wild-type ...
... human cancers, which can occur independent of  p53 
Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents
Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents
Mujoo, Kalpana; Watanabe, Masayuki; Nakamura, Junichi; Khokhar, Abdul R.; Siddik, Zahid H.
gene status; however, the presence of wild-type ...
... heat shock protein 70 family. Mortalin binds to  p53 
Mortalin is a prognostic factor of gastric cancer with normal p53 function
Mortalin is a prognostic factor of gastric cancer with normal p53 function
Ando, Koji; Oki, Eiji; Zhao, Yan; Ikawa-Yoshida, Ayae; Kitao, Hiroyuki; Saeki, Hiroshi; Kimura, Yasue; Ida, Satoshi; Morita, Masaru; Kusumoto, Tetsuya; Maehara, Yoshihiko
and prevents ...
... studies that the absence in cancer cells of the  p53 
Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type-p53 but not in p53-mutated bladder cancer cells
Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type-p53 but not in p53-mutated bladder cancer cells
Hinata, Nobuyuki; Shirakawa, Toshiro; Zhang, Zhujun; Matsumoto, Akira; Fujisawa, Masato; Okada, Hiroshi; Kamidono, Sadao; Gotoh, Akinobu
tumor suppressor gene, mutations of which are ...
... Bid. However, the role of caspase-8 in  p53 
Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells
Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells
Liu, Juan; Uematsu, Hiroshi; Tsuchida, Nobuo; Ikeda, Masa-Aki
- and p73-dependent apoptosis induced by ...
... in regulation of the tumor suppressor  p53 
Rad9 modulates the P21WAF1pathway by direct association with p53
Rad9 modulates the P21WAF1pathway by direct association with p53
Ishikawa, Kazuhiro; Ishii, Hideshi; Murakumo, Yoshiki; Mimori, Koshi; Kobayashi, Masahiko; Yamamoto, Ken-ichi; Mori, Masaki; Nishino, Hiroshi; Furukawa, Yusuke; Ichimura, Keiichi
-dependent transactivation of pro-survival P21 ...
... Wild-type sequence (wt)  p53 
CD4+ T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head and neck cancer
CD4+ T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head and neck cancer
Chikamatsu, Kazuaki; Sakakura, Koichi; Takahashi, Goro; Okamoto, Atsushi; Furuya, Nobuhiko; Whiteside, Theresa L.; DeLeo, Albert B.; Masuyama, Keisuke
peptides are attractive candidates for broadly ...
... the role of Chk2 using Molt-4 cells with  p53 
Checkpoint kinase 2 is dispensable for regulation of the p53 response but is required for G2/M arrest and cell survival in cells with p53 defects under heat stress
Checkpoint kinase 2 is dispensable for regulation of the p53 response but is required for G2/M arrest and cell survival in cells with p53 defects under heat stress
Furusawa, Yukihiro; Yamanouchi, Yuka; Iizumi, Takashi; Zhao, Qing-Li; Mitsuhashi, Yohei; Morita, Akinori; Enomoto, Atushi; Tabuchi, Yoshiaki; Kondo, Takashi
-targeted shRNA (Molt-4/shp53) and parental ...
... Background Although the presence of serum  p53 
Perioperative Changes of Serum p53 Antibody Titer is a Predictor for Survival in Patients with Esophageal Squamous Cell Carcinoma
Perioperative Changes of Serum p53 Antibody Titer is a Predictor for Survival in Patients with Esophageal Squamous Cell Carcinoma
Shimada, Hideaki; Shiratori, Tooru; Takeda, Akihiko; Matsushita, Kazuyuki; Okazumi, Shinichi; Akutsu, Yasunori; Matsubara, Hisahiro; Nomura, Fumio; Ochiai, Takenori
antibody (s- ...
... of the determinants of impaired chemosensitivity.  p53 
Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?
Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?
Osumi, Hiroki; Shinozaki, Eiji; Suenaga, Mitsukuni; Kumekawa, Yosuke; Ogura, Mariko; Ozaka, Masato; Matsusaka, Satoshi; Chin, Keisho; Yamamoto, Noriko; Mizunuma, Nobuyuki
is a tumor-suppressor protein in humans encoded ...
... the clinicopathological significance of the  p53 
Serum p53 antibody as a potential tumor marker in extrahepatic cholangiocarcinoma
Serum p53 antibody as a potential tumor marker in extrahepatic cholangiocarcinoma
Okada, Rei; Shimada, Hideaki; Otsuka, Yuichiro; Tsuchiya, Masaru; Ishii, Jun; Katagiri, Toshio; Maeda, Tetsuya; Kubota, Yoshihisa; Nemoto, Tetsuo; Kaneko, Hironori
protein expression and s- ...
... class II binding peptide from the tumor protein  p53 
Induction of tumor-reactive T helper responses by a posttranslational modified epitope from tumor protein p53
Induction of tumor-reactive T helper responses by a posttranslational modified epitope from tumor protein p53
Kumai, Takumi; Ishibashi, Kei; Oikawa, Kensuke; Matsuda, Yoshinari; Aoki, Naoko; Kimura, Shoji; Hayashi, Satoshi; Kitada, Masahiro; Harabuchi, Yasuaki; Celis, Esteban; Kobayashi, Hiroya
, which possesses an acetylated lysine at ...
... been shown to inactivate tumor suppressor protein  p53 
Mortalin-p53 Interaction as a Target for Liver Cancer Therapy
Mortalin-p53 Interaction as a Target for Liver Cancer Therapy
Lu, Wen-Jing; Lee, Nikki P.; Wadhwa, Renu; Luk, John M.
. ...