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... Background The  p53 
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Wachter, Franziska; Grunert, Michaela; Blaj, Cristina; Weinstock, David M; Jeremias, Irmela; Ehrhardt, Harald
protein is the best studied target in human ...
... mediate and regulate tumor suppression exerted by  p53 
The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches
The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches
Hünten, Sabine; Siemens, Helge; Kaller, Markus; Hermeking, Heiko
. ...
... the second as backup. Not necessarily so with  p53 
Resistance of mitochondrial p53 to dominant inhibition
Resistance of mitochondrial p53 to dominant inhibition
Heyne, Kristina; Schmitt, Katrin; Mueller, Daniel; Armbruester, Vivienne; Mestres, Pedro; Roemer, Klaus
. ...
... expression, carry a missense mutation at the  p53 
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Gottschalk, Benjamin; Klein, Andreas
codon 242 (mouse G242 corresponds to human hot ...
... Background The  p53 
Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway
Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway
Zhang, Ping; Kratz, Anne Sophie; Salama, Mohammed; Elabd, Seham; Heinrich, Thorsten; Wittbrodt, Joachim; Blattner, Christine; Davidson, Gary
tumor suppressor protein is mainly regulated by ...
... Background  P53 
Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage
Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage
Solozobova, Valeriya; Rolletschek, Alexandra; Blattner, Christine
is a key tumor suppressor protein. ...
... by expression plasmids that encode mutant  p53 
DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis
DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis
Humar, Matjaz; Maurer, Martina; Azemar, Marc; Groner, Bernd
was conducted to characterize exogenously induced ...
... Purpose  p53 
Delivery of a Monomeric p53 Subdomain with Mitochondrial Targeting Signals from Pro-Apoptotic Bak or Bax
Delivery of a Monomeric p53 Subdomain with Mitochondrial Targeting Signals from Pro-Apoptotic Bak or Bax
Matissek, Karina J.; Okal, Abood; Mossalam, Mohanad; Lim, Carol S.
targeted to the mitochondria is the fastest and ...
... Background The tumor suppressor protein  p53 
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
Loewer, Alexander; Karanam, Ketki; Mock, Caroline; Lahav, Galit
is activated by cellular stress. ...
... attenuates the function of the tumor suppressor  p53 
Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels
Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels
Schilling, Daniela; Düwel, Michael; Molls, Michael; Multhoff, Gabriele
. ...
... The tumor suppressor  p53 
p53-dependent pathways in neurite outgrowth and axonal regeneration
p53-dependent pathways in neurite outgrowth and axonal regeneration
Giovanni, Simone; Rathore, Khizr
is a multifunctional sensor of a number of ...
... as well as hypoxia leads to an increase of  p53 
Regulation of p53 under hypoxic and inflammatory conditions in periodontium
Regulation of p53 under hypoxic and inflammatory conditions in periodontium
Memmert, S.; Gölz, L.; Pütz, P.; Jäger, A.; Deschner, J.; Appel, T.; Baumgarten, G.; Rath-Deschner, B.; Frede, S.; Götz, W.
protein levels. ...
... Introduction In advanced ovarian cancers (OCs),  p53 
The role of p53 as a surrogate marker for chemotherapeutical responsiveness in ovarian cancer
The role of p53 as a surrogate marker for chemotherapeutical responsiveness in ovarian cancer
Bauerschlag, Dirk O.; Schem, Christian; Weigel, Marion T.; Kaisenberg, Constantin; Strauss, Alexander; Bauknecht, Thomas; Maass, Nicolai; Meinhold-Heerlein, Ivo
mutations are frequently observed. ...
... factor in colorectal cancer. Moreover, an altered  p53 
Analysis of neuroendocrine differentiation and the p53/BAX pathway in UICC stage III colorectal carcinoma identifies patients with good prognosis
Analysis of neuroendocrine differentiation and the p53/BAX pathway in UICC stage III colorectal carcinoma identifies patients with good prognosis
Grabowski, Patricia; Sturm, Isrid; Schelwies, Katharina; Maaser, Kerstin; Buhr, Heinz-Johannes; Dörken, Bernd; Zeitz, Martin; Daniel, Peter T.; Scherübl, Hans
/BAX pathway is associated with a poor clinical ...
... anti-apoptotic properties via enhancing Mdm2-  p53 
Evidence for anti-apoptotic roles of proteasome activator 28γ via inhibiting caspase activity
Evidence for anti-apoptotic roles of proteasome activator 28γ via inhibiting caspase activity
Moncsek, Anja; Gruner, Melanie; Meyer, Hannes; Lehmann, Andrea; Kloetzel, Peter-Michael; Stohwasser, Ralf
interaction, thereby facilitating ubiquitination ...
... of the MCP-1 upstream region proposed a putative  p53 
Regulation of MCP-1 chemokine transcription by p53
Regulation of MCP-1 chemokine transcription by p53
Hacke, Katrin; Rincon-Orozco, Bladimiro; Buchwalter, Gilles; Siehler, Simone Y.; Wasylyk, Bohdan; Wiesmüller, Lisa; Rösl, Frank
binding side about 2.5 kb upstream of the ...
... investigated. Similarly, the relationship between  p53 
p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737
p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737
Tagscherer, Katrin E.; Fassl, Anne; Sinkovic, Tabea; Combs, Stephanie E.; Roth, Wilfried
function and the pro-apoptotic effects of ABT-737 ...
... Background The role of pERK, pAKT and  p53 
pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104
pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104
Ormanns, Steffen; Siveke, Jens T; Heinemann, Volker; Haas, Michael; Sipos, Bence; Schlitter, Anna Melissa; Esposito, Irene; Jung, Andreas; Laubender, Rüdiger P; Kruger, Stephan; Vehling-Kaiser, Ursula; Winkelmann, Cornelia; Fischer von Weikersthal, Ludwig; Clemens, Michael R; Gauler, Thomas C; Märten, Angela; Geissler, Michael; Greten, Tim F; Kirchner, Thomas; Boeck, Stefan
as biomarkers in patients with advanced ...
... and activate the transcription factor  p53 
Role of the nucleus in apoptosis: signaling and execution
Role of the nucleus in apoptosis: signaling and execution
Prokhorova, Evgeniia A.; Zamaraev, Alexey V.; Kopeina, Gelina S.; Zhivotovsky, Boris; Lavrik, Inna N.
either directly or by means of prior activation ...
... we demonstrate that Sgk1 activates MDM2-dependent  p53 
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation
Amato, Rosario; D’Antona, Lucia; Porciatti, Giovanni; Agosti, Valter; Menniti, Miranda; Rinaldo, Cinzia; Costa, Nicola; Bellacchio, Emanuele; Mattarocci, Stefano; Fuiano, Giorgio; Soddu, Silvia; Paggi, Marco G.; Lang, Florian; Perrotti, Nicola
ubiquitylation. ...
... transcription mediated by tumor suppressor  p53 
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
Wang, Ying; Debatin, Klaus-Michael; Hug, Hubert
responsive promoter elements. ...
... Background The tumor suppressor gene  p53 
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Baumbusch, Lars O; Myhre, Simen; Langerød, Anita; Bergamaschi, Anna; Geisler, Stephanie B; Lønning, Per E; Deppert, Wolfgang; Dornreiter, Irene; Børresen-Dale, Anne-Lise
(TP53) controls numerous signaling pathways and ...
... Background The cellular regulatory protein  p53 
An MVA vaccine overcomes tolerance to human p53 in mice and humans
An MVA vaccine overcomes tolerance to human p53 in mice and humans
Song, Guang-Yun; Gibson, Glen; Haq, Wahajul; Huang, Eric C. C.; Srivasta, Tumul; Hollstein, Monica; Daftarian, Pirouz; Wang, Zhongde; Diamond, Don; Ellenhorn, Joshua D. I.
is overexpressed by almost 50% of all ...
... apoptosis, we conditionally deleted one allele of  p53 
Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation
Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation
Kotb, Ahmed M; Hierholzer, Andreas; Kemler, Rolf
in Ncadk.i. mice and observed a temporal rescue ...
...  p53 
p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis in Response to Oxidative Damage
p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis in Response to Oxidative Damage
Zirngibl, Katharina; Moll, Ute M.
, originally discovered as the most important ...

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