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... approach to treat cancers with dysfunctional  p53 
Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo
Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo
Lu, Yi; Zhang, Zhisong; Yan, Zhenwen; Chen, Li; Deng, Weimin; Lotze, Michael; Wang, Zhou; Lin, Xinli; Li, Lu-Yuan
tumor suppressor gene is to reinstate ...
... As a critical tumor suppressor,  p53 
Functional analysis of the acetylation of human p53 in DNA damage responses
Functional analysis of the acetylation of human p53 in DNA damage responses
Chung, Sun-Ku; Zhu, Shengyun; Xu, Yang; Fu, Xuemei
is inactivated in human cancer cells by somatic ...
... organelles responsible for vital cell functions.  p53 
p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases
p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases
Dai, Chun-Qiu; Luo, Ting-Ting; Luo, Shi-Cheng; Wang, Jia-Qi; Wang, Sheng-Ming; Bai, Yun-Hu; Yang, Yan-Ling; Wang, Ya-Yun
is a transcription factor that regulates the DNA ...
... The  p53 
USP11 regulates p53 stability by deubiquitinating p53
USP11 regulates p53 stability by deubiquitinating p53
Ke, Jia-ying; Dai, Cong-jie; Wu, Wen-lin; Gao, Jin-hua; Xia, Ai-juan; Liu, Guang-ping; Lv, Kao-sheng; Wu, Chun-lin
tumor suppressor protein coordinates the cellular ...
... in breast cancer, we identified IBP was a novel  p53 
Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells
Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells
Yang, Mingzhen; Yuan, Fang; Li, Peng; Chen, Zhongjiao; Chen, An; Li, Shuhui; Hu, Chuanmin
target gene. ...
... miRNAs in colon cancer cell lines HCT116  p53 
Dynamic analysis of DNA damage induced miRNAs in colon cancer cells
Dynamic analysis of DNA damage induced miRNAs in colon cancer cells
Zhang, Weimin; Yang, Fang; Zhan, Qimin
+/+ and HCT116 ...
... It has been reported that  p53 
An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma
An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma
Gong, Zhaojian; Yang, Qian; Zeng, Zhaoyang; Zhang, Wenling; Li, Xiayu; Zu, Xuyu; Deng, Hao; Chen, Pan; Liao, Qianjin; Xiang, Bo; Zhou, Ming; Li, Xiaoling; Li, Yong; Xiong, Wei; Li, Guiyuan
dysfunction is closely related to the ...
... been shown to inactivate tumor suppressor protein  p53 
Mortalin-p53 Interaction as a Target for Liver Cancer Therapy
Mortalin-p53 Interaction as a Target for Liver Cancer Therapy
Lu, Wen-Jing; Lee, Nikki P.; Wadhwa, Renu; Luk, John M.
. ...
... studies demonstrated that Meq is able to bind  p53 
The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities
The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities
Deng, Xufang; Li, Xiangdong; Shen, Yang; Qiu, Yafeng; Shi, Zixue; Shao, Donghua; Jin, Yamei; Chen, Hongjun; Ding, Chan; Li, Li; Chen, Puyan; Ma, Zhiyong
in vitro, as demonstrated using a protein-binding ...
... Background  p53 
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Zhang, Lili; Nie, Linghu; Maki, Carl G
is a tumor suppressor and potent inhibitor of ...
... stroke in rats to further investigate whether the  p53 
XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53-DRAM pathway
XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53-DRAM pathway
Wei, Gang; Huang, YueChun; Li, Fei; Zeng, FeiJian; Li, YiWei; Deng, RuDong; Lai, YingTao; Zhou, JianHong; Huang, GuiHua; Chen, DongFeng
-DRAM pathway is involved in the effects of XNJ ...
... The tumor suppressor  p53 
PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway
PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway
Xu, Lanjun; Hu, Jing; Zhao, Yuanbo; Hu, Jia; Xiao, Juan; Wang, Yanming; Ma, Dalong; Chen, Yingyu
is at the hub of cellular signaling networks that ...
... Dominant-negative somatic mutations of  p53 
p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis
p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis
Zhang, Ting; Li, Huihua; Shi, Juan; Li, Sha; Li, Muyuan; Zhang, Lei; Zheng, Leting; Zheng, Dexian; Tang, Fulin; Zhang, Xuan; Zhang, Fengchun; You, Xin
has been identified in the synovium of patients ...
... In this study, we studied the effects of  p53 
p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells
p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells
Wang, Mei-Juan; Pei, Dong-Sheng; Qian, Guo-Wei; Yin, Xiao-Xing; Cheng, Qian; Li, Lian-Tao; Li, Hui-Zhong; Zheng, Jun-Nian
on Ki-67 promoter in HeLa cells using luciferase ...
... Background The  p53 
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Chen, Xi; Chen, Jia; Gan, Siting; Guan, Huaji; Zhou, Yuan; Ouyang, Qi; Shi, Jue
pathway is differentially activated in response ...
... The  p53 
Prognostic effect of p53 expression in patients with completely resected colorectal cancer
Prognostic effect of p53 expression in patients with completely resected colorectal cancer
Liu, Bin-Wei; Liu, Yang; Liu, Jun-Ru; Feng, Zhong-Xu; Liu, Tong
protein is closely involved in the carcinogenesis ...
... relationship between mitochondrial dysfunction,  p53 
The globular heads of the C1q receptor regulate apoptosis in human cervical squamous carcinoma cells via a p53-dependent pathway
The globular heads of the C1q receptor regulate apoptosis in human cervical squamous carcinoma cells via a p53-dependent pathway
Chen, Zheng-lin; Gu, Ping-qing; Liu, Kangsheng; Su, Ya-juan; Gao, Ling-juan
status and gC1qR expression and the regulation of ...
... the wild-type (wt) form of the tumor suppressor  p53 
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
Wang, Fei; Liu, Jianfeng; Robbins, Delira; Morris, Kerri; Sit, Amos; Liu, Yong-Yu; Zhao, Yunfeng
, can translocate to mitochondria due to ...
... in cervical cancer and head and neck cancer.  p53 
p53 expression but not p16INK4A correlates with human papillomavirus-associated esophageal squamous cell carcinoma in Kazakh population
p53 expression but not p16INK4A correlates with human papillomavirus-associated esophageal squamous cell carcinoma in Kazakh population
Wang, Lianghai; Li, Jing; Hou, Jun; Li, Man; Cui, Xiaobin; Li, Shugang; Yu, Xiaodan; Zhang, Zhiyu; Liang, Weihua; Jiang, Jinfang; Pang, Lijuan; Chen, Yunzhao; Zhao, Jin; Li, Feng
has also been reported as a feasible marker to ...
... studied single nucleotide polymorphism (SNP) of  p53 
Expression of pAkt affects p53 codon 72 polymorphism-based prediction of response to radiotherapy in nasopharyngeal carcinoma
Expression of pAkt affects p53 codon 72 polymorphism-based prediction of response to radiotherapy in nasopharyngeal carcinoma
Xie, Xiaoxue; Wang, Hui; Jin, Hekun; Ouyang, Shuyu; Zhou, Jumei; Hu, Jun; Xi, Xuping; Luo, Junming; Zhang, Yingying; Hu, Bingqiang
to date, is associated with the ability of the ...
... focused on anti-tumor effect of pEGFP-C1-  p53 
The anti-tumor effect of p53 gene-loaded hydroxyapatite nanoparticles in vitro and in vivo
The anti-tumor effect of p53 gene-loaded hydroxyapatite nanoparticles in vitro and in vivo
Zhao, Ruibo; Yang, Xinyan; Chen, Cen; Chen, Kan; Wang, Shibing; Xie, Chungang; Ren, Xiaoyuan; Kong, Xiangdong
( ...
... study, a combination of recombinant adenoviral  p53 
Selective intra-arterial infusion of rAd-p53 with chemotherapy for advanced oral cancer: a randomized clinical trial
Selective intra-arterial infusion of rAd-p53 with chemotherapy for advanced oral cancer: a randomized clinical trial
Li, Yi; Li, Long-Jiang; Wang, Li-Juan; Zhang, Zhuang; Gao, Ning; Liang, Chen-Yuan; Huang, Yuan-Ding; Han, Bo
(rAd- ...
... the function of tumor suppressor protein  p53 
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Dixit, Updesh; Liu, Zhihe; Pandey, Ashutosh K; Kothari, Ramesh; Pandey, Virendra N
. ...
... The  p53 
p53 is an independent prognostic factor in operable esophageal squamous cell carcinoma: a large-scale study with a long follow-up
p53 is an independent prognostic factor in operable esophageal squamous cell carcinoma: a large-scale study with a long follow-up
Xu, Xiao-Ling; Zheng, Wei-Hui; Tao, Kai-Yi; Li, Xian-Xing; Xu, Wei-Zhen; Wang, Yin; Zhu, Shuang-Mei; Mao, Wei-Min
protein is involved in many biological functions ...
...  p53 
Noncoding RNAs Regulating p53 and c-Myc Signaling
Noncoding RNAs Regulating p53 and c-Myc Signaling
Mei, Yide; Wu, Mian
is one of the most important tumor suppressors ...

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