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... tumor suppressor in multicellular organisms,  p53 
p53
p53
Menendez, Daniel; Nguyen, Thuy-Ai; Resnick, Michael A.; Anderson, Carl W.
is one of the most intensively studied human ...
... This effect allowed a downregulation of the  p53 
Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection
Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection
Hasna, Jessy; Hague, Frédéric; Rodat-Despoix, Lise; Geerts, Dirk; Leroy, Catherine; Tulasne, David; Ouadid-Ahidouch, Halima; Kischel, Philippe
tumor suppressor protein expression via the ...
... section, a novel approach for identifying MDM2-  p53 
Development of a Mirror-Image Screening System for Chiral Natural Products
Development of a Mirror-Image Screening System for Chiral Natural Products
Noguchi, Taro
and MDMX- ...
... we focus on the regulatory module of the protein  p53 
Influence of the Stochasticity in Threshold Localization on Cell Fate in the PLDE-Model of the P53 Module
Influence of the Stochasticity in Threshold Localization on Cell Fate in the PLDE-Model of the P53 Module
Ochab, Magdalena; Swierniak, Andrzej; Klamka, Jerzy; Puszynski, Krzysztof
, which is responsible for cell responses to DNA ...
... minute 2 protein ; HDM2 (human homolog of MDM2) ;  p53 
MDM2 (Murine Double Minute 2)
MDM2 (Murine Double Minute 2)
Bang, Scott; Bhatt, Heeruk C.; Chen, Yun Yue; Kurokawa, Manabu
-binding protein MDM2 Historical Background Mdm2 ...
... MDM4) ; HDMX (human homolog of MDMX) ; Mdm2-like  p53 
MDM4 (Murine Double Minute 4)
MDM4 (Murine Double Minute 4)
Huang, Annie; Yang, Emily; Kurokawa, Manabu
-binding protein ; MDMX (murine double minute X) ...
... The positive expression rates were 47% for  p53 
Correlation Between Biomarker Candidate Proteins with the Effect of Neoadjuvant Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma
Correlation Between Biomarker Candidate Proteins with the Effect of Neoadjuvant Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma
Noda, Masahiro; Okumura, Hiroshi; Uchikado, Yasuto; Omoto, Itaru; Sasaki, Ken; Kita, Yoshiaki; Mori, Shinichiro; Owaki, Tetsuhiro; Arigami, Takaaki; Uenosono, Yoshikazu; Nakajo, Akihiro; Kijima, Yuko; Ishigami, Sumiya; Maemura, Kosei; Natsugoe, Shoji
, 83% for CDC25B, 68% for 14-3-3sigma, 76% for ...
... of intercellular adhesion molecule 1 (ICAM-1),  p53 
Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction
Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction
Eleftheriadis, Theodoros; Pissas, Georgios; Antoniadi, Georgia; Liakopoulos, Vassilios; Stefanidis, Ioannis
and phosphorylated ...
... CRE-mediated flox activity to render mice  p53 
Defining the Pathways of Urogenital Schistosomiasis-Associated Urothelial Carcinogenesis through Transgenic and Bladder Wall Egg Injection Models
Defining the Pathways of Urogenital Schistosomiasis-Associated Urothelial Carcinogenesis through Transgenic and Bladder Wall Egg Injection Models
Mbanefo, Evaristus C.; Hsieh, Michael H.
haploinsufficient before challenging them with ...
... initial tumor tissue expressions of survivin,  p53 
Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor
Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor
Karpinsky, Gabrielle; Krawczyk, Malgorzata A.; Izycka-Swieszewska, Ewa; Fatyga, Aleksandra; Budka, Agnieszka; Balwierz, Walentyna; Sobol, Grazyna; Zalewska-Szewczyk, Beata; Rychlowska-Pruszynska, Magdalena; Klepacka, Teresa; Dembowska-Baginska, Bozenna; Kazanowska, Bernarda; Gabrych, Anna; Bien, Ewa
, cyclin D1, osteopontin (OPN) and fibronectin ...
... genes, namely APC, KRAS, BRAF, PIK3CA, SMAD4 and  p53 
Mutations of key driver genes in colorectal cancer progression and metastasis
Mutations of key driver genes in colorectal cancer progression and metastasis
Huang, Dongdong; Sun, Wenjie; Zhou, Yuwei; Li, Peiwei; Chen, Fang; Chen, Hanwen; Xia, Dajing; Xu, Enping; Lai, Maode; Wu, Yihua; Zhang, Honghe
. ...
... 2 (MDM2) negatively regulates the activity of the  p53 
Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53
Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53
He, Tianli; Guo, Jiayou; Song, Hongmei; Zhu, Hongcheng; Di, Xiaoke; Min, Hua; Wang, Yuandong; Chen, Guangzong; Dai, Wangshu; Ma, Jianhua; Sun, Xinchen; Ma, Jianxin
protein and plays a vital role in cell cycle ...
... of the inhibitors on tumor growth [68] Floxedc  p53 
Modeling Bladder Cancer with Genetic Engineering: Fidelity of Human-to-Laboratory Models
Modeling Bladder Cancer with Genetic Engineering: Fidelity of Human-to-Laboratory Models
Wu, Xue-Ru
/PTEN Adeno-Cre (intravesical) CIS/MIBC Rapamycin ...
... the influence of melatonin on expression of  p53 
The effect of melatonin on expression of p53 and ovarian preantral follicle development isolated from vitrified ovary
The effect of melatonin on expression of p53 and ovarian preantral follicle development isolated from vitrified ovary
Mazoochi, Tahere; Khamechian, Tahere; Ehteram, Mohammad; Kashani, Hamed Haddad
and the developmental rate of preantral follicles ...
... et al. 2009), whereas the tumor suppressor,  p53 
S100A6
S100A6
Donato, Rosario; Sorci, Guglielmo; Giambanco, Ileana
, acts indirectly to suppress transcription via ...
... depend on other tumor suppressors such as  p53 
Tumor suppressor C-RASSF proteins
Tumor suppressor C-RASSF proteins
Iwasa, Hiroaki; Hossain, Shakhawoat; Hata, Yutaka
, pRb, and the Hippo pathway, C-RASSF proteins ...
... p-GSK3β expression, cyclophilin D inhibition, and  p53 
CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice
CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice
Hseu, You-Cheng; Thiyagarajan, Varadharajan; Ou, Ting-Tsz; Yang, Hsin-Ling
activation through ROS are involved in ...
... rate, are characterized by alterations in the  p53 
Risk Factors and Molecular Features Associated with Bladder Cancer Development
Risk Factors and Molecular Features Associated with Bladder Cancer Development
Mitra, Anirban P.; Bartsch, Georg, Jr.; Cote, Richard J.
and retinoblastoma pathways. ...
... and proteins involved in apoptosis (Bax, Bcl-2,  p53 
Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells
Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells
Luu, Trang H.; Bard, Jean-Marie; Carbonnelle, Delphine; Chaillou, Chloé; Huvelin, Jean-Michel; Bobin-Dubigeon, Christine; Nazih, Hassan
) and lipogenesis (SREBP-1c, FASN, ACACA). ...
... in PML-NBs phosphorylates PML and binds to  p53 
CHEK2
CHEK2
Buscemi, Giacomo; Zannini, Laura
, thus regulating PML-NBs number and ...
... (Lopez-Sanchez et al. 2009); the C-terminus with  p53 
VRK1
VRK1
Cantarero, Lara; Moura, David S.; Salzano, Marcella; Monsalve, Diana M.; Campillo-Marcos, Ignacio; Martín-Doncel, Elena; Lazo, Pedro A.
(Lopez-Sanchez et al. 2014); and both regions ...
... activity on H3K4, and methylation of  p53 
Histone methylation in the freeze-tolerant wood frog (Rana sylvatica)
Histone methylation in the freeze-tolerant wood frog (Rana sylvatica)
Hawkins, Liam J.; Storey, Kenneth B.
(p53K370me2 and p53K372me1) in the skeletal ...
... proteins such as the tumor suppressor protein  p53 
Ginkgo biloba, DNA Damage and DNA Repair: Overview
Ginkgo biloba, DNA Damage and DNA Repair: Overview
Oliveira, Daniela; Johansson, Bjorn; Oliveira, Rui
, the DNA damage and repair factor xeroderma ...
... MGMT promoter methylation status, and ATRX,  p53 
Analysis of immunobiologic markers in primary and recurrent glioblastoma
Analysis of immunobiologic markers in primary and recurrent glioblastoma
Rahman, Maryam; Kresak, Jesse; Yang, Changlin; Huang, Jianping; Hiser, Wesley; Kubilis, Paul; Mitchell, Duane
, and IDH1 mutation status. ...
... phenotype, the epithelial-mesenchymal transition,  p53 
Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients
Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients
Ebili, Henry Okuchukwu; Iyawe, Victoria O.; Adeleke, Kikelomo Rachel; Salami, Babatunde Abayomi; Banjo, Adekunbiola Aina; Nolan, Chris; Rakha, Emad; Ellis, Ian; Green, Andrew; Agboola, Ayodeji Olayinka Johnson
over-expression, DNA homologous repair pathway ...