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... tumor suppressor in multicellular organisms,  p53 
p53
p53
Menendez, Daniel; Nguyen, Thuy-Ai; Resnick, Michael A.; Anderson, Carl W.
is one of the most intensively studied human ...
... of glutathione (GSH) and dependency of  p53 
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Banerjee, Kaushik; Das, Satyajit; Majumder, Saikat; Majumdar, Subrata; Biswas, Jaydip; Choudhuri, Soumitra Kumar
status on the modulation of GSH-mediated ...
... poorly known. We identify the presence of three  p53 
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Kelkar, Madhura G.; Thakur, Bhushan; Derle, Abhishek; Chatterjee, Sushmita; Ray, Pritha; De, Abhijit
binding sites on the human NIS promoter sequence ...
... Background Mechanisms that inactivate the  p53 
Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Abramowitz, Julia; Neuman, Tzahi; Perlman, Riki; Ben-Yehuda, Dina
pathway in Acute Myeloid Leukemia (AML), other ...
... smoking, alcohol, and human papillomavirus (HPV).  p53 
p53 in Head and Neck Squamous Cell Carcinoma
p53 in Head and Neck Squamous Cell Carcinoma
Philips, Ramez; Pan, Quintin
, a transcriptional factor, is the most commonly ...
... conventional treatments and is often defective in  p53 
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
Shimazu, Kengo; Tada, Yuji; Morinaga, Takao; Shingyoji, Masato; Sekine, Ikuo; Shimada, Hideaki; Hiroshima, Kenzo; Namiki, Takao; Tatsumi, Koichiro; Tagawa, Masatoshi
pathways. ...
... heterogeneous in their origins, mutations in the  p53 
The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene
The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene
Levine, Arnold J
gene and inactivation of ...
... Although the preoperative serum level of  p53 
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Yamashita, Kotaro; Makino, Tomoki; Tanaka, Koji; Yamasaki, Makoto; Yamamoto, Masaaki; Miyazaki, Yasuhiro; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro
antibodies (s- ...
... to DNA lesions. The focal accumulation of  p53 
Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants
Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants
Suchánková, Jana; Legartová, Soňa; Ručková, Eva; Vojtěšek, Bořivoj; Kozubek, Stanislav; Bártová, Eva
binding protein, 53BP1, is a main feature ...
... Here, we examine the impact of ERβ on the ERα-  p53 
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer
Lu, Wenwen; Katzenellenbogen, Benita S.
loop in breast cancer. ...
...  p53 
Tissue-Specific Functions of p53 During Kidney Development
Tissue-Specific Functions of p53 During Kidney Development
Saifudeen, Zubaida
is best identified as a tumor suppressor for its ...
... of Rac1, a small G-protein, in the activation of  p53 
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells
Sidarala, Vaibhav; Kowluru, Anjaneyulu
and ATM kinase in pancreatic β-cells, under the ...
...  P53 
P53, Immunology
P53, Immunology
DeLeo, Albert; Whiteside, Theresa L.
is one of the most frequently mutated suppressor ...
... the clinicopathological significance of the  p53 
Serum p53 antibody as a potential tumor marker in extrahepatic cholangiocarcinoma
Serum p53 antibody as a potential tumor marker in extrahepatic cholangiocarcinoma
Okada, Rei; Shimada, Hideaki; Otsuka, Yuichiro; Tsuchiya, Masaru; Ishii, Jun; Katagiri, Toshio; Maeda, Tetsuya; Kubota, Yoshihisa; Nemoto, Tetsuo; Kaneko, Hironori
protein expression and s- ...
... as a tumor suppressor via multiple mechanisms.  p53 
RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?
RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?
Lee, Jung-Won; Wijnen, Andre; Bae, Suk-Chul
-related pathways play central roles in tumor ...
... The role of  p53 
p53 switches off pluripotency on differentiation
p53 switches off pluripotency on differentiation
Lin, Tongxiang; Lin, Yi
as “a guardian of the genome” has been well ...
... been clear so far. The tumor suppressor protein  p53 
Effect of potential role of p53 on embryo development arrest induced by H2O2 in mouse
Effect of potential role of p53 on embryo development arrest induced by H2O2 in mouse
Hu, De-Bao; Li, Zhong-Shu; Ali, Ihsan; Xu, Li-Jie; Fang, Nan-Zhu
controls cell cycle and programmed cell death by ...
... The binding of the  p53 
p53 induction and cell viability modulation by genotoxic individual chemicals and mixtures
p53 induction and cell viability modulation by genotoxic individual chemicals and mixtures
Di Paolo, Carolina; Müller, Yvonne; Thalmann, Beat; Hollert, Henner; Seiler, Thomas-Benjamin
tumor suppression protein to DNA response ...
... this review, we discuss the findings of adipose  p53 
Molecular connections of obesity and aging: a focus on adipose protein 53 and retinoblastoma protein
Molecular connections of obesity and aging: a focus on adipose protein 53 and retinoblastoma protein
Chu, Dinh-Toi; Tao, Yang
and Rb—two central molecular linkages between ...
... degradation of proapoptotic proteins such as  p53 
MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes
MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes
Lagunas-Martínez, Alfredo; García-Villa, Enrique; Arellano-Gaytán, Magaly; Contreras-Ochoa, Carla O.; Dimas-González, Jisela; López-Arellano, María E.; Madrid-Marina, Vicente; Gariglio, Patricio
, employing the proteasome pathway. ...
... The tumour suppressor gene  p53 
Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway
Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway
Kumari, Ratna; Chouhan, Surbhi; Singh, Snahlata; Chhipa, Rishi Raj; Ajay, Amrendra Kumar; Bhat, Manoj Kumar
is mutated in approximately 50% of the human ...
... analyses and found that several genes in the  p53 
Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells
Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells
Okuda, Akiko; Kurokawa, Suguru; Takehashi, Masanori; Maeda, Aika; Fukuda, Katsuya; Kubo, Yukari; Nogusa, Hyuma; Takatani-Nakase, Tomoka; Okuda, Shujiro; Ueda, Kunihiro; Tanaka, Seigo
signaling pathway were upregulated, including ...
... triggers a DNA damage response, which activates  p53 
Senescence, Apoptosis, and Cancer
Senescence, Apoptosis, and Cancer
Dimri, Manjari; Dimri, Goberdhan P.
pathway resulting in proliferation arrest ...
...  p53 
Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity
Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity
Lu, Tao; Kim, Paul P.; Greig, Nigel H.; Luo, Yu
plays an essential role in the regulation of cell ...
... and the lack of expression of protein 53 (  p53 
Relationship Between the Expression of O6-Methylguanine-DNA Methyltransferase (MGMT) and p53, and the Clinical Response in Metastatic Pancreatic Adenocarcinoma Treated with FOLFIRINOX
Relationship Between the Expression of O6-Methylguanine-DNA Methyltransferase (MGMT) and p53, and the Clinical Response in Metastatic Pancreatic Adenocarcinoma Treated with FOLFIRINOX
Vitellius, Carole; Eymerit-Morin, Caroline; Luet, Dominique; Fizanne, Lionel; Foubert, Fanny; Bertrais, Sandrine; Rousselet, Marie-Christine; Caroli-Bosc, François-Xavier
) could interfere with the action of MGMT. ...