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... The tumor suppressor  p53 
Molecularly targeted therapies for p53-mutant cancers
Molecularly targeted therapies for p53-mutant cancers
Zhao, Dekuang; Tahaney, William M.; Mazumdar, Abhijit; Savage, Michelle I.; Brown, Powel H.
is lost or mutated in approximately half of human ...
... tumor suppressor in multicellular organisms,  p53 
p53
p53
Menendez, Daniel; Nguyen, Thuy-Ai; Resnick, Michael A.; Anderson, Carl W.
is one of the most intensively studied human ...
... of glutathione (GSH) and dependency of  p53 
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Banerjee, Kaushik; Das, Satyajit; Majumder, Saikat; Majumdar, Subrata; Biswas, Jaydip; Choudhuri, Soumitra Kumar
status on the modulation of GSH-mediated ...
... Background The  p53 
Evolution of the p53-MDM2 pathway
Evolution of the p53-MDM2 pathway
Åberg, Emma; Saccoccia, Fulvio; Grabherr, Manfred; Ore, Wai Ying Josefin; Jemth, Per; Hultqvist, Greta
signalling pathway, which controls cell fate, has ...
... Background The function of  p53 
The impact of p53 on the early stage replication of retrovirus
The impact of p53 on the early stage replication of retrovirus
Kinnetz, Michaela; Alghamdi, Faris; Racz, Michael; Hu, Wenwei; Shi, Binshan
in cancer biology has been studied extensively, ...
... Background Mechanisms that inactivate the  p53 
Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Abramowitz, Julia; Neuman, Tzahi; Perlman, Riki; Ben-Yehuda, Dina
pathway in Acute Myeloid Leukemia (AML), other ...
... poorly known. We identify the presence of three  p53 
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Kelkar, Madhura G.; Thakur, Bhushan; Derle, Abhishek; Chatterjee, Sushmita; Ray, Pritha; De, Abhijit
binding sites on the human NIS promoter sequence ...
... smoking, alcohol, and human papillomavirus (HPV).  p53 
p53 in Head and Neck Squamous Cell Carcinoma
p53 in Head and Neck Squamous Cell Carcinoma
Philips, Ramez; Pan, Quintin
, a transcriptional factor, is the most commonly ...
... Here, we examine the impact of ERβ on the ERα-  p53 
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer
Lu, Wenwen; Katzenellenbogen, Benita S.
loop in breast cancer. ...
... amplified in transformed murine cells. It is a  p53 
MDM2
MDM2
Meek, David W.
-binding nuclear protein that antagonizes and ...
... conventional treatments and is often defective in  p53 
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
Shimazu, Kengo; Tada, Yuji; Morinaga, Takao; Shingyoji, Masato; Sekine, Ikuo; Shimada, Hideaki; Hiroshima, Kenzo; Namiki, Takao; Tatsumi, Koichiro; Tagawa, Masatoshi
pathways. ...
... heterogeneous in their origins, mutations in the  p53 
The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene
The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene
Levine, Arnold J
gene and inactivation of ...
... Although the preoperative serum level of  p53 
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Yamashita, Kotaro; Makino, Tomoki; Tanaka, Koji; Yamasaki, Makoto; Yamamoto, Masaaki; Miyazaki, Yasuhiro; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro
antibodies (s- ...
... to DNA lesions. The focal accumulation of  p53 
Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants
Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants
Suchánková, Jana; Legartová, Soňa; Ručková, Eva; Vojtěšek, Bořivoj; Kozubek, Stanislav; Bártová, Eva
binding protein, 53BP1, is a main feature ...
...  p53 
Tissue-Specific Functions of p53 During Kidney Development
Tissue-Specific Functions of p53 During Kidney Development
Saifudeen, Zubaida
is best identified as a tumor suppressor for its ...
... of Rac1, a small G-protein, in the activation of  p53 
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells
Sidarala, Vaibhav; Kowluru, Anjaneyulu
and ATM kinase in pancreatic β-cells, under the ...
...  P53 
P53, Immunology
P53, Immunology
DeLeo, Albert; Whiteside, Theresa L.
is one of the most frequently mutated suppressor ...
... The gene product of the tumor suppressor  p53 
Gain-of-Function p53
Gain-of-Function p53
Blandino, Giovanni
represents a paradigm of a protein whose ...
... Indeed, the two proteins act as regulators of  P53 
MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
Tisato, Veronica; Voltan, Rebecca; Gonelli, Arianna; Secchiero, Paola; Zauli, Giorgio
, a well-known key controller of the cell cycle ...
... the clinicopathological significance of the  p53 
Serum p53 antibody as a potential tumor marker in extrahepatic cholangiocarcinoma
Serum p53 antibody as a potential tumor marker in extrahepatic cholangiocarcinoma
Okada, Rei; Shimada, Hideaki; Otsuka, Yuichiro; Tsuchiya, Masaru; Ishii, Jun; Katagiri, Toshio; Maeda, Tetsuya; Kubota, Yoshihisa; Nemoto, Tetsuo; Kaneko, Hironori
protein expression and s- ...
... regulatory networks [25, 28, 41–43], such as the  p53 
A step-by-step microRNA guide to cancer development and metastasis
A step-by-step microRNA guide to cancer development and metastasis
Markopoulos, Georgios S.; Roupakia, Eugenia; Tokamani, Maria; Chavdoula, Evangelia; Hatziapostolou, Maria; Polytarchou, Christos; Marcu, Kenneth B.; Papavassiliou, Athanasios G.; Sandaltzopoulos, Raphael; Kolettas, Evangelos
-miRNA [25, 28, 43–45] and the NF-κB-miRNA [28, ...
... as a tumor suppressor via multiple mechanisms.  p53 
RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?
RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?
Lee, Jung-Won; Wijnen, Andre; Bae, Suk-Chul
-related pathways play central roles in tumor ...
... The transcription factor tumor protein  p53 
New Phage Display-Isolated Heptapeptide Recognizing the Regulatory Carboxy-Terminal Domain of Human Tumour Protein p53
New Phage Display-Isolated Heptapeptide Recognizing the Regulatory Carboxy-Terminal Domain of Human Tumour Protein p53
Ben Abid, Sihem; Sahnoun, Mouna; Yacoubi-Hadj Amor, Ines; Abdelmoula-Souissi, Salma; Hassairi, Hajer; Mokdad-Gargouri, Raja; Gargouri, Ali
( ...
... behavior. Their expression is downregulated by  p53 
Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors
Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors
Dragoj, Miodrag; Bankovic, Jasna; Sereti, Evangelia; Stojanov, Sofija Jovanovic; Dimas, Konstantinos; Pesic, Milica; Stankovic, Tijana
and PTEN tumor suppressors which are commonly ...
... The role of  p53 
p53 switches off pluripotency on differentiation
p53 switches off pluripotency on differentiation
Lin, Tongxiang; Lin, Yi
as “a guardian of the genome” has been well ...