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... of glutathione (GSH) and dependency of  p53 
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Banerjee, Kaushik; Das, Satyajit; Majumder, Saikat; Majumdar, Subrata; Biswas, Jaydip; Choudhuri, Soumitra Kumar
status on the modulation of GSH-mediated ...
... Although the preoperative serum level of  p53 
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Yamashita, Kotaro; Makino, Tomoki; Tanaka, Koji; Yamasaki, Makoto; Yamamoto, Masaaki; Miyazaki, Yasuhiro; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro
antibodies (s- ...
... of Rac1, a small G-protein, in the activation of  p53 
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells
Sidarala, Vaibhav; Kowluru, Anjaneyulu
and ATM kinase in pancreatic β-cells, under the ...
... as a tumor suppressor via multiple mechanisms.  p53 
RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?
RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?
Lee, Jung-Won; Wijnen, Andre; Bae, Suk-Chul
-related pathways play central roles in tumor ...
... The role of  p53 
p53 switches off pluripotency on differentiation
p53 switches off pluripotency on differentiation
Lin, Tongxiang; Lin, Yi
as “a guardian of the genome” has been well ...
... The binding of the  p53 
p53 induction and cell viability modulation by genotoxic individual chemicals and mixtures
p53 induction and cell viability modulation by genotoxic individual chemicals and mixtures
Di Paolo, Carolina; Müller, Yvonne; Thalmann, Beat; Hollert, Henner; Seiler, Thomas-Benjamin
tumor suppression protein to DNA response ...
... been clear so far. The tumor suppressor protein  p53 
Effect of potential role of p53 on embryo development arrest induced by H2O2 in mouse
Effect of potential role of p53 on embryo development arrest induced by H2O2 in mouse
Hu, De-Bao; Li, Zhong-Shu; Ali, Ihsan; Xu, Li-Jie; Fang, Nan-Zhu
controls cell cycle and programmed cell death by ...
... degradation of proapoptotic proteins such as  p53 
MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes
MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes
Lagunas-Martínez, Alfredo; García-Villa, Enrique; Arellano-Gaytán, Magaly; Contreras-Ochoa, Carla O.; Dimas-González, Jisela; López-Arellano, María E.; Madrid-Marina, Vicente; Gariglio, Patricio
, employing the proteasome pathway. ...
... The tumour suppressor gene  p53 
Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway
Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway
Kumari, Ratna; Chouhan, Surbhi; Singh, Snahlata; Chhipa, Rishi Raj; Ajay, Amrendra Kumar; Bhat, Manoj Kumar
is mutated in approximately 50% of the human ...
... analyses and found that several genes in the  p53 
Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells
Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells
Okuda, Akiko; Kurokawa, Suguru; Takehashi, Masanori; Maeda, Aika; Fukuda, Katsuya; Kubo, Yukari; Nogusa, Hyuma; Takatani-Nakase, Tomoka; Okuda, Shujiro; Ueda, Kunihiro; Tanaka, Seigo
signaling pathway were upregulated, including ...
... triggers a DNA damage response, which activates  p53 
Senescence, Apoptosis, and Cancer
Senescence, Apoptosis, and Cancer
Dimri, Manjari; Dimri, Goberdhan P.
pathway resulting in proliferation arrest ...
... cell lines which expressed mutant or inactive  p53 
HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature
HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature
Mattison, Stacey A; Blatch, Gregory L; Edkins, Adrienne L
. ...
... are urgently needed. Apoptosis-stimulating  P53 
Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study
Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study
Xie, Xiao-Feng; Yang, Qing; Chi, Jun; Yang, Xian-Zi; Wang, Hui-Yun; Xu, Guo-Liang
-binding protein 1 (ASPP1) and 2 (ASPP2) have ...
... lymph node specimens were analyzed for p16 and  p53 
Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters
Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters
Yildirim, Müjdat; Müller von der Grün, Jens; Winkelmann, Ria; Fokas, Emmanouil; Rödel, Franz; Ackermann, Hanns; Rödel, Claus; Balermpas, Panagiotis
immunoreactivity. ...
... NCCs through p38 MAPK-mediated activation of the  p53 
Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway
Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway
Yuan, Fuqiang; Chen, Xiaopan; Liu, Jie; Feng, Wenke; Wu, Xiaoyang; Chen, Shao-yu
signaling pathway. ...
...  p53 
Molecular Basis of Skin Carcinogenesis
Molecular Basis of Skin Carcinogenesis
Pacifico, Alessia; Leone, Giovanni; Ananthaswamy, Honnavara N.
tumor suppressor gene is the most commonly ...
... not completely defined, although the pRb and  p53 
The Role of Sumoylation in Senescence
The Role of Sumoylation in Senescence
Scurr, Lyndee L.; Haferkamp, Sebastian; Rizos, Helen
tumor suppressor pathways converge with the SUMO ...
... HIF-1α was inhibited by BP-1T in various  p53 
BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation
BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation
Thirusangu, Prabhu; Vigneshwaran, V.; Prashanth, T.; Vijay Avin, B. R.; Malojirao, Vikas H.; Rakesh, H.; Khanum, Shaukath Ara; Mahmood, Riaz; Prabhakar, B. T.
(WT)-expressing cancer cells, including A549, ...
... influence of silver nanoparticles (AgNPs) on the  p53 
Polyvinyl pyrrolidone-coated silver nanoparticles in a human lung cancer cells: time- and dose-dependent influence over p53 and caspase-3 protein expression and epigenetic effects
Polyvinyl pyrrolidone-coated silver nanoparticles in a human lung cancer cells: time- and dose-dependent influence over p53 and caspase-3 protein expression and epigenetic effects
Blanco, Jordi; Lafuente, Daisy; Gómez, Mercedes; García, Tánia; Domingo, José L.; Sánchez, Domènec J.
tumor suppressor protein. ...
... efficiency in several hematologic malignancies.  P53 
Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a
Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a
Qiang, Wei; Sui, Fang; Ma, Jingjing; Li, Xinru; Ren, Xiaojuan; Shao, Yuan; Liu, Jiazhe; Guan, Haixia; Shi, Bingyin; Hou, Peng
-dependent apoptosis has been reported to be a ...
... investigate the regulation of mTORC1 by MDM4, a  p53 
MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability
MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability
Mancini, Francesca; Teveroni, Emanuela; Di Conza, Giusy; Monteleone, Valentina; Arisi, Ivan; Pellegrino, Marsha; Buttarelli, Marianna; Pieroni, Luisa; D’Onofrio, Mara; Urbani, Andrea; Pontecorvi, Alfredo; Mazzone, Massimiliano; Moretti, Fabiola
-inhibitor with oncogenic or anti-survival ...
... mutated transcription factor in HCC is the TP53/  p53 
Etiology and Pathogenesis of Hepatocellular Carcinoma: Transcription Factors, Signal Pathways Regulating Proliferation and Apoptosis, and Telomeres/Telomerases
Etiology and Pathogenesis of Hepatocellular Carcinoma: Transcription Factors, Signal Pathways Regulating Proliferation and Apoptosis, and Telomeres/Telomerases
Zimmermann, Arthur
gene, one of the most commonly mutated gene in ...
... after surgical treatment for breast cancer, serum  p53 
Detection of the early phase of esophageal cancer progression into lamina propria mucosae by the serum p53 antibody
Detection of the early phase of esophageal cancer progression into lamina propria mucosae by the serum p53 antibody
Saito, Fumi; Shimada, Hideaki; Ogata, Hideaki; Otsuka, Takafumi; Nemoto, Tetsuo; Shibuya, Kazutoshi; Kaneko, Hironori
antibody levels suddenly increased in a ...
... family in neuronal differentiation and identified  P53 
Regulation of miR-34 Family in Neuronal Development
Regulation of miR-34 Family in Neuronal Development
Jauhari, Abhishek; Singh, Tanisha; Singh, Parul; Parmar, Devendra; Yadav, Sanjay
as mediator of nerve growth factor (NGF) induced ...
... human breast cancer models with a different  p53 
Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer
Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer
Xiong, Jing; Li, Jiansha; Yang, Qin; Wang, Jun; Su, Tiefen; Zhou, Sheng
status. ...