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... induced claudin-low-like TNBC. The effect of  p53 
Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Wang, Sharon; Liu, Jeff C.; Kim, Danbi; Datti, Alessandro; Zacksenhaus, Eldad
mutation plus Pten deletion on mammary ...
...  p53 
Noncoding RNAs Regulating p53 and c-Myc Signaling
Noncoding RNAs Regulating p53 and c-Myc Signaling
Mei, Yide; Wu, Mian
is one of the most important tumor suppressors ...
... is the multifunctional transcription factor  p53 
p53 Replacement Therapy for Cancer
p53 Replacement Therapy for Cancer
Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi
gene that regulates diverse cellular phenomena ...
... neurons of the substantia nigra pars compacta.  p53 
Direct α-synuclein promoter transactivation by the tumor suppressor p53
Direct α-synuclein promoter transactivation by the tumor suppressor p53
Duplan, Eric; Giordano, Cécile; Checler, Frédéric; Alves da Costa, Cristine
is a major neuronal pro-apoptotic factor that is ...
... Tumor suppressor  p53 
Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
Kim, Young June; Kim, Tae-Hyun; Kim, Minjeong; Kim, Min Ju; Kim, Hae-Won; Shim, Hosup
plays a critical role in the regulation of cell ...
... organelles responsible for vital cell functions.  p53 
p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases
p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases
Dai, Chun-Qiu; Luo, Ting-Ting; Luo, Shi-Cheng; Wang, Jia-Qi; Wang, Sheng-Ming; Bai, Yun-Hu; Yang, Yan-Ling; Wang, Ya-Yun
is a transcription factor that regulates the DNA ...
... Dominant-negative somatic mutations of  p53 
p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis
p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis
Zhang, Ting; Li, Huihua; Shi, Juan; Li, Sha; Li, Muyuan; Zhang, Lei; Zheng, Leting; Zheng, Dexian; Tang, Fulin; Zhang, Xuan; Zhang, Fengchun; You, Xin
has been identified in the synovium of patients ...
... review explains the mechanism of regulation of  p53 
Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53–MDM2 Interaction Useful in Targeted Cancer Therapy
Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53–MDM2 Interaction Useful in Targeted Cancer Therapy
Gupta, Alpana K.; Bharadwaj, Mausumi; Kumar, Anoop; Mehrotra, Ravi
(tumor suppressor protein) by MDM2 and ...
... in the sequence of the tumor-suppressor protein  p53 
Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax
Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax
Domankevich, Vered; Opatowsky, Yarden; Malik, Assaf; Korol, Abraham B.; Frenkel, Zeev; Manov, Irena; Avivi, Aaron; Shams, Imad
, a master regulator of the DNA-damage response ...
... studies have shown that aberrant activation of  p53 
Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis
Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis
Ishimura, Akihiko; Terashima, Minoru; Tange, Shoichiro; Suzuki, Takeshi
signaling leads to embryonic lethality. ...
... these kinases stabilize effector proteins like  p53 
The DNA damage-induced cell death response: a roadmap to kill cancer cells
The DNA damage-induced cell death response: a roadmap to kill cancer cells
Matt, Sonja; Hofmann, Thomas G.
or Cdc25 by phosphorylation. ...
... as well as hypoxia leads to an increase of  p53 
Regulation of p53 under hypoxic and inflammatory conditions in periodontium
Regulation of p53 under hypoxic and inflammatory conditions in periodontium
Memmert, S.; Gölz, L.; Pütz, P.; Jäger, A.; Deschner, J.; Appel, T.; Baumgarten, G.; Rath-Deschner, B.; Frede, S.; Götz, W.
protein levels. ...
... As will be described in a later section, the  p53 
Cancer Gene Pathways
Cancer Gene Pathways
Bunz, Fred
protein is a node of several critical pathways ...
... Interestingly, an increase in phosphorylation of  p53 
The Ras/Raf/Erk Pathway Mediates the Subarachnoid Hemorrhage-Induced Apoptosis of Hippocampal Neurons Through Phosphorylation of p53
The Ras/Raf/Erk Pathway Mediates the Subarachnoid Hemorrhage-Induced Apoptosis of Hippocampal Neurons Through Phosphorylation of p53
Feng, Dayun; Wang, Bao; Ma, Yulong; Shi, Wei; Tao, Kai; Zeng, Weijun; Cai, Qing; Zhang, Zhiguo; Qin, Huaizhou
was paralleled with p-Erk, and PD98059 also ...
... therapy correlates with the ability to induce a  p53 
p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines
p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines
Ye, Shunan; Shen, Jacson; Choy, Edwin; Yang, Cao; Mankin, Henry; Hornicek, Francis; Duan, Zhenfeng
-dependent apoptotic response. ...
... were obtained. Immunohistochemistry of  p53 
Oral Free Paper Sessions
Oral Free Paper Sessions
, C-Myc, HIF1-alpha, VEGF, Oct-4, Aldh1A1, CD34, ...
... host cell apoptosis through up-regulation of  p53 
p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells
p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells
Xu, Dan; Du, Qian; Han, Cong; Wang, Zengguo; Zhang, Xiujuan; Wang, Tongtong; Zhao, Xiaomin; Huang, Yong; Tong, Dewen
. ...
... We investigated the role of BRCA1, MDM2, and  p53 
BRCA1 and MDM2 as independent blood-based biomarkers of head and neck cancer
BRCA1 and MDM2 as independent blood-based biomarkers of head and neck cancer
Bhowmik, Aditi; Das, Sambuddha; Bhattacharjee, Abhinandan; Choudhury, Biswadeep; Naiding, Momota; Ghosh, Sankar Kumar; Choudhury, Yashmin
in the pathogenesis of head and neck cancer (HNC) ...
... It has been reported that  p53 
An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma
An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma
Gong, Zhaojian; Yang, Qian; Zeng, Zhaoyang; Zhang, Wenling; Li, Xiayu; Zu, Xuyu; Deng, Hao; Chen, Pan; Liao, Qianjin; Xiang, Bo; Zhou, Ming; Li, Xiaoling; Li, Yong; Xiong, Wei; Li, Guiyuan
dysfunction is closely related to the ...
... In our study, we examined the efficacy of  p53 
p53 gene therapy of human breast carcinoma: using a transferrin-modified silica nanoparticles
p53 gene therapy of human breast carcinoma: using a transferrin-modified silica nanoparticles
Rejeeth, Chandrababu; Kannan, Soundrapandian
gene therapy in human breast carcinoma (MCF-7) ...
...  P53 
P53, Immunology
P53, Immunology
DeLeo, Albert; Whiteside, Theresa L
is one of the most frequently mutated suppressor ...
... of HIV-1 infection. The tumor suppressor factor  p53 
Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs
Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs
Shin, YoungHyun; Lim, Hoyong; Choi, Byeong-Sun; Kim, Kyung-Chang; Kang, Chun; Bae, Yong-Soo; Yoon, Cheol-Hee
is activated by HIV-1 infection, and restricts ...
... promising new approach for treatment of cancers.  P53 
Recombinant Newcastle disease virus expressing P53 demonstrates promising antitumor efficiency in hepatoma model
Recombinant Newcastle disease virus expressing P53 demonstrates promising antitumor efficiency in hepatoma model
An, Ying; Liu, Tianyan; He, Jinjiao; Wu, Hongsong; Chen, Rui; Liu, Yunye; Wu, Yunzhou; Bai, Yin; Guo, Xiaochen; Zheng, Qi; Liu, Chang; Yin, Jiechao; Li, Deshan; Ren, Guiping
plays a vital role in tumor suppression and ...
... aspirin acetylated the tumor suppressor protein  p53 
Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53
Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53
Ai, Guoqiang; Dachineni, Rakesh; Kumar, D. Ramesh; Marimuthu, Srinivasan; Alfonso, Lloyd F.; Bhat, G. Jayarama
at lysine 382 in MDA-MB-231 human breast cancer ...
... The tumor suppressor  p53 
CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo
CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo
He, Xing-Xing; Zhang, Yu-Nan; Yan, Jun-Wei; Yan, Jing-Jun; Wu, Qian; Song, Yu-Hu
is one of the most frequently mutated genes in ...