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... The  p53 
p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
Giono, Luciana E.; Ladelfa, M. Fátima; Monte, Martín
tumor suppressor is a transcription factor that ...
... The tumour suppressor  p53 
The role of DNA damage responses in p53 biology
The role of DNA damage responses in p53 biology
Speidel, Daniel
is a central player in cellular DNA damage ...
... pathways or cell cycle arrest. High frequency of  p53 
Sentinel Gene Within Cell Territory and Molecular Platforms in Cancer: Methylation Diversity of p53 Gene in Brain Tumors
Sentinel Gene Within Cell Territory and Molecular Platforms in Cancer: Methylation Diversity of p53 Gene in Brain Tumors
Mehdipour, Parvin; Karami, Fatemeh
gene aberrations in various types of cancer has ...
... further the interaction between BM2 and  p53 
The BM2 protein of influenza B virus interacts with p53 and inhibits its transcriptional and apoptotic activities
The BM2 protein of influenza B virus interacts with p53 and inhibits its transcriptional and apoptotic activities
Zhang, H.; Yu, H.; Wang, J.; Zhang, M.; Wang, X.; Ahmad, W.; Duan, M.; Guan, Z.
to confirm our previous studies using yeast ...
... Introduction  p53 
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Zhao, Kai; Zhou, Yuxin; Qiao, Chen; Ni, Ting; Li, Zhiyu; Wang, Xiaotang; Guo, Qinglong; Lu, Na; Wei, Libin
plays important roles in regulating the metabolic ...
... harbor somatic mutations of the tumor suppressor  p53 
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
Guo, Gang; Cui, Yan
( ...
... fate. Mutations within the TP53 (tumor suppressor  p53 
p53 regulates cytoskeleton remodeling to suppress tumor progression
p53 regulates cytoskeleton remodeling to suppress tumor progression
Araki, Keigo; Ebata, Takahiro; Guo, Alvin Kunyao; Tobiume, Kei; Wolf, Steven John; Kawauchi, Keiko
) gene leading to loss or gain of function (GOF) ...
... of the human tumor suppressor protein  P53 
Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast
Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast
Kamoun, Yosra; Mabrouk, Imed; Delahodde, Agnes; Boukid, Fatma; Yacoubi-Hadj Amor, Ines; Mokdad-Gargouri, Raja; Gargouri, Ali
causes cell death of the yeast Saccharomyces ...
... and activate the transcription factor  p53 
Role of the nucleus in apoptosis: signaling and execution
Role of the nucleus in apoptosis: signaling and execution
Prokhorova, Evgeniia A.; Zamaraev, Alexey V.; Kopeina, Gelina S.; Zhivotovsky, Boris; Lavrik, Inna N.
either directly or by means of prior activation ...
... Background The  p53 
Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway
Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway
Zhang, Ping; Kratz, Anne Sophie; Salama, Mohammed; Elabd, Seham; Heinrich, Thorsten; Wittbrodt, Joachim; Blattner, Christine; Davidson, Gary
tumor suppressor protein is mainly regulated by ...
... are detailing with increasing precision the  p53 
Whole-genome cartography of p53 response elements ranked on transactivation potential
Whole-genome cartography of p53 response elements ranked on transactivation potential
Tebaldi, Toma; Zaccara, Sara; Alessandrini, Federica; Bisio, Alessandra; Ciribilli, Yari; Inga, Alberto
-directed gene regulatory network that, ...
... The  p53 
Targeting p53 Tumor Suppressor for AML Therapy
Targeting p53 Tumor Suppressor for AML Therapy
Kensuke, Kojima; Vassilev, Lyubomir T.
tumor suppressor gene is mutated in over half of ...
... a mutation causes Parkinson’s disease (PD), and  p53 
Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
Ho, Dong Hwan; Kim, Hyejung; Kim, Jisun; Sim, Hyuna; Ahn, Hyunjun; Kim, Janghwan; Seo, Hyemyung; Chung, Kwang Chul; Park, Bum-Joon; Son, Ilhong; Seol, Wongi
is a prototype tumor suppressor. ...
... study, our objective was to determine the role of  p53 
Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells
Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells
Çoker-Gürkan, Ajda; Arisan, Elif Damla; Obakan, Pınar; Palavan-Unsal, Narçin
in the DENSpm-induced autophagy/apoptotic ...
... cell line involving the tumor suppressor protein  p53 
The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells
The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells
Raza, Shaneabbas; Ohm, Joyce E.; Dhasarathy, Archana; Schommer, Jared; Roche, Conor; Hammer, Kimberly D. P.; Ghribi, Othman
. ...
... of melanomas harbor alterations in cell cycle and  p53 
Targeting the Cell Cycle and p53 in Combination with BRAF-Directed Therapy
Targeting the Cell Cycle and p53 in Combination with BRAF-Directed Therapy
Han, Dale; Smalley, Keiran SM
regulatory pathways such as loss of CDKN2A and ...
... anti-apoptotic properties via enhancing Mdm2-  p53 
Evidence for anti-apoptotic roles of proteasome activator 28γ via inhibiting caspase activity
Evidence for anti-apoptotic roles of proteasome activator 28γ via inhibiting caspase activity
Moncsek, Anja; Gruner, Melanie; Meyer, Hannes; Lehmann, Andrea; Kloetzel, Peter-Michael; Stohwasser, Ralf
interaction, thereby facilitating ubiquitination ...
... Mutations in the  p53 
Adiposity is associated with p53 gene mutations in breast cancer
Adiposity is associated with p53 gene mutations in breast cancer
Ochs-Balcom, Heather M.; Marian, Catalin; Nie, Jing; Brasky, Theodore M.; Goerlitz, David S.; Trevisan, Maurizio; Edge, Stephen B.; Winston, Janet; Berry, Deborah L.; Kallakury, Bhaskar V.; Freudenheim, Jo L.; Shields, Peter G.
gene are among the most frequent genetic events ...
... stroke in rats to further investigate whether the  p53 
XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53-DRAM pathway
XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53-DRAM pathway
Wei, Gang; Huang, YueChun; Li, Fei; Zeng, FeiJian; Li, YiWei; Deng, RuDong; Lai, YingTao; Zhou, JianHong; Huang, GuiHua; Chen, DongFeng
-DRAM pathway is involved in the effects of XNJ ...
... of the determinants of impaired chemosensitivity.  p53 
Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?
Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?
Osumi, Hiroki; Shinozaki, Eiji; Suenaga, Mitsukuni; Kumekawa, Yosuke; Ogura, Mariko; Ozaka, Masato; Matsusaka, Satoshi; Chin, Keisho; Yamamoto, Noriko; Mizunuma, Nobuyuki
is a tumor-suppressor protein in humans encoded ...
... ribonucleotide reductase has been identified as a  p53 
E2F1 regulates p53R2 gene expression in p53-deficient cells
E2F1 regulates p53R2 gene expression in p53-deficient cells
Qi, Jun-Juan; Liu, Ling; Cao, Ji-Xiang; An, Guo-Shun; Li, Shu-Yan; Li, Gang; Jia, Hong-Ti; Ni, Ju-Hua
-inducible gene. ...
... induced by hyperglycemia has been associated with  p53 
Hyperglycemia promotes p53-Mdm2 interaction but reduces p53 ubiquitination in RINm5F cells
Hyperglycemia promotes p53-Mdm2 interaction but reduces p53 ubiquitination in RINm5F cells
Raúl, Barzalobre-Gerónimo; Antonio, Flores-López Luis; Arturo, Baiza-Gutman Luis; Miguel, Cruz; Rebeca, García-Macedo; Alejandro, Ávalos-Rodríguez; Alejandra, Contreras-Ramos; Margarita, Díaz-Flores; Clara, Ortega-Camarillo
mobilization to mitochondria and ...
... and cell death. Further, the mitochondrial CypD–  p53 
Modelling the molecular mechanism of protein–protein interactions and their inhibition: CypD–p53 case study
Modelling the molecular mechanism of protein–protein interactions and their inhibition: CypD–p53 case study
Fayaz, S. M.; Rajanikant, G. K.
axis is an important contributor to necroptosis, ...
... and human health impacts. The protein  p53 
The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials
The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials
Belade, Esther; Chrusciel, Sandra; Armand, Lucie; Simon-Deckers, Angélique; Bussy, Cyrill; Caramelle, Philippe; Gagliolo, Jean-Marie; Boyer, Laurent; Lanone, Sophie; Pairon, Jean-Claude; Kermanizadeh, Ali; Boczkowski, Jorge
is a key transcription factor implicated in ...
... The  p53 
Splice-acceptor site mutation in p53 gene of hu888 zebrafish line
Splice-acceptor site mutation in p53 gene of hu888 zebrafish line
Piasecka, Alicja; Brzuzan, Paweł; Woźny, Maciej; Ciesielski, Sławomir; Kaczmarczyk, Dariusz
transcription factor is a key tumor suppressor ...

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