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... by this role of nucleoli is the tumor suppressor  p53 
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Vlatković, Nikolina; Boyd, Mark T.; Rubbi, Carlos P.
, which is activated in response to diverse ...
... findings suggesting a pro-oncogenic role for  p53 
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Girardini, Javier E.; Walerych, Dawid; Sal, Giannino
point mutants, more than 30 years of research ...
... The presence of a functional  p53 
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
Levav-Cohen, Yaara; Goldberg, Zehavit; Tan, Kah Hin; Alsheich-Bartok, Osnat; Zuckerman, Valentina; Haupt, Sue; Haupt, Ygal
protein is a key factor for the proper ...
... in the genesis and progression of cancer, mutant  p53 
Mutant p53 and the Response to Chemotherapy and Radiation
Mutant p53 and the Response to Chemotherapy and Radiation
Tchelebi, Leila; Ashamalla, Hani; Graves, Paul R.
also appears to play a significant role in the ...
... The tumor suppressor  p53 
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Zhang, Qi; Zeng, Shelya X.; Lu, Hua
plays a central role in anti-tumorigenesis and ...
... point mutation of TP53 or through disruption of  p53 
p53 in Head and Neck Cancer
p53 in Head and Neck Cancer
Roh, Jong-Lyel; Koch, Wayne M.
protein function as a consequence of oncogenic ...
... harbor mutations in the tumor suppressor  p53 
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Chander, Harish; Brien, Colin D; Truesdell, Peter; Watt, Kathleen; Meens, Jalna; Schick, Colleen; Germain, Doris; Craig, Andrew WB
, we tested whether ...
... accumulation of PTEN and its interaction with  p53 
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Das, Ranjita; Bhattacharya, Kaushik; Sarkar, Sayantani; Samanta, Suman Kumar; Pal, Bikas C.; Mandal, Chitra
/p73. ...
... Loss of function of  p53 
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Yu, Xin; Narayanan, Sumana; Vazquez, Alexei; Carpizo, Darren R.
, either through mutations in the gene or through ...
... Tumor suppressor  p53 
The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism
The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism
Budanov, Andrei V.
is inactivated in most cancers and the critical ...
... Purpose  p53 
Delivery of a Monomeric p53 Subdomain with Mitochondrial Targeting Signals from Pro-Apoptotic Bak or Bax
Delivery of a Monomeric p53 Subdomain with Mitochondrial Targeting Signals from Pro-Apoptotic Bak or Bax
Matissek, Karina J.; Okal, Abood; Mossalam, Mohanad; Lim, Carol S.
targeted to the mitochondria is the fastest and ...
... the function of tumor suppressor protein  p53 
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Dixit, Updesh; Liu, Zhihe; Pandey, Ashutosh K; Kothari, Ramesh; Pandey, Virendra N
. ...
... recent evidence suggests that tumour suppressor  p53 
Crosstalk Between p53 and Mitochondrial Metabolism
Crosstalk Between p53 and Mitochondrial Metabolism
Itahana, Koji; Pervaiz, Shazib
actively participates in these communications. ...
... Background  p53 
Characterization of a new mouse p53 variant: loss-of-function and gain-of-function
Characterization of a new mouse p53 variant: loss-of-function and gain-of-function
Chan, James Yi-Hsin; Chen, Ying-Chuan; Liu, Shu-Ting; Chou, Wei-Yuan; Ho, Ching-Liang; Huang, Shih-Ming
is a major tumor suppressor that is inactivated ...
... As a critical tumor suppressor,  p53 
Functional analysis of the acetylation of human p53 in DNA damage responses
Functional analysis of the acetylation of human p53 in DNA damage responses
Chung, Sun-Ku; Zhu, Shengyun; Xu, Yang; Fu, Xuemei
is inactivated in human cancer cells by somatic ...
...  p53 
Mechanisms of Mutant p53 Stabilization in Cancer
Mechanisms of Mutant p53 Stabilization in Cancer
Frum, Rebecca A.; Grossman, Steven R.
transactivates cell cycle inhibitory, apoptosis ...
... cells. HCT 116 colorectal cancer cells expressing  p53 
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Beaino, Wissam; Guo, Yunjun; Chang, Albert J.; Anderson, Carolyn J.
(+/+) and not expressing ...
... miRNAs in colon cancer cell lines HCT116  p53 
Dynamic analysis of DNA damage induced miRNAs in colon cancer cells
Dynamic analysis of DNA damage induced miRNAs in colon cancer cells
Zhang, Weimin; Yang, Fang; Zhan, Qimin
+/+ and HCT116 ...
... of abnormal cells. The tumor suppressor protein,  p53 
The DNA Damage Response Mediates Apoptosis and Tumor Suppression
The DNA Damage Response Mediates Apoptosis and Tumor Suppression
Baran, Katherine; Rodriguez, Diego; Green, Douglas
, is one of the most essential molecules keeping ...
... represent two critical cellular regulators of the  p53 
Mdm2 and MdmX Involvement in Human Cancer
Mdm2 and MdmX Involvement in Human Cancer
Berberich, Steven J.
tumor suppressor. ...
...  p53 
p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis in Response to Oxidative Damage
p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis in Response to Oxidative Damage
Zirngibl, Katharina; Moll, Ute M.
, originally discovered as the most important ...
... time. Codon-specific hotspot mutations of  p53 
The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma
The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma
Karsy, Michael; Albert, Ladislau; Murali, Raj; Jhanwar-Uniyal, Meena
result in constitutively active mutant ...
... p21 promoter constructs revealed that  p53 
Transcriptional activation of p21WAF1/CIP1 is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts
Transcriptional activation of p21WAF1/CIP1 is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts
Kim, Hyun-Seok; Heo, Jee-In; Park, Seong-Hoon; Shin, Jong-Yeon; Kang, Hong-Jun; Kim, Min-Ju; Kim, Sung Chan; Kim, Jaebong; Park, Jae-Bong; Lee, Jae-Yong
binding site was the most important site and Sp1 ...
...  p53 
p53: Its Mutations and Their Impact on Transcription
p53: Its Mutations and Their Impact on Transcription
Vaughan, Catherine; Pearsall, Isabella; Yeudall, Andrew; Deb, Swati Palit; Deb, Sumitra
is a tumor suppressor protein whose key function ...
... suppressor and guardian of the genome known as  p53 
Nucleolar Signaling Determines Cell Fate: The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis
Nucleolar Signaling Determines Cell Fate: The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis
Liu, Yong; Zhang, Yanping
. ...

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