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... Reinstatement of the  p53 
p53-Reactivating Molecules as Research Tools and Anticancer Drugs
p53-Reactivating Molecules as Research Tools and Anticancer Drugs
Grinkevich, Vera V.; Warnecke, Andreas; Selivanova, Galina
tumor suppressor function in cancers by small ...
... Most tumors inactivate the  p53 
Mutant p53-Driven Tumorigenesis
Mutant p53-Driven Tumorigenesis
Terzian, Tamara; Lozano, Guillermina
tumor suppressor pathway via single nucleotide ...
... of the Forkhead box (Fox; Sect. 10.9.3) and  P53 
Other Major Types of Signaling Mediators
Other Major Types of Signaling Mediators
Thiriet, Marc
families (Sect. 10.9.4; Table 10.1). Other ...
... MTI-induced cell death. Especially, the role of  p53 
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
Kim, Jae Hyeong; Yoon, Eun-Kyung; Chung, Hye-Jin; Park, Seong-Yeol; Hong, Kyeong-Man; Lee, Chang-Hun; Lee, Yeon-Su; Choi, Kyungho; Yang, Young; Kim, Kyungtae; Kim, In-Hoo
in this process has been controversial for a long ...
... in each subtype, alterations of tumor suppressor  p53 
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
England, Bryant; Huang, Tiangui; Karsy, Michael
are the most common, seen in 25–30 % of primary ...
... mediate and regulate tumor suppression exerted by  p53 
The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches
The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches
Hünten, Sabine; Siemens, Helge; Kaller, Markus; Hermeking, Heiko
. ...
... Methods We performed computer modeling of the  p53 
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Golubovskaya, Vita M; Ho, Baotran; Zheng, Min; Magis, Andrew; Ostrov, David; Morrison, Carl; Cance, William G
peptide containing the site of interaction with ...
... Background The  p53 
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Chen, Xi; Chen, Jia; Gan, Siting; Guan, Huaji; Zhou, Yuan; Ouyang, Qi; Shi, Jue
pathway is differentially activated in response ...
... Background The tumor suppressor  p53 
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Bisio, Alessandra; De Sanctis, Veronica; Del Vescovo, Valerio; Denti, Michela A; Jegga, Anil G; Inga, Alberto; Ciribilli, Yari
is a sequence-specific transcription factor that ...
... that can restore biological activity of mutant  p53 
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Knowell, Ashley E; Patel, Divya; Morton, Derrick J; Sharma, Pankaj; Glymph, Shanora; Chaudhary, Jaideep
are an area of high interest given that mutant ...
... are redundant and deeply interconnected. The  p53 
TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer
TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer
Hainaut, Pierre
protein, encoded by the TP53 tumor suppressor ...
... approach to treat cancers with dysfunctional  p53 
Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo
Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo
Lu, Yi; Zhang, Zhisong; Yan, Zhenwen; Chen, Li; Deng, Weimin; Lotze, Michael; Wang, Zhou; Lin, Xinli; Li, Lu-Yuan
tumor suppressor gene is to reinstate ...
...  p53 
Senescence Regulation by the p53 Protein Family
Senescence Regulation by the p53 Protein Family
Qian, Yingjuan; Chen, Xinbin
, a guardian of the genome, exerts its tumor ...
... of mutant forms of the tumour suppressor  p53 
Upstream Targets in the p53 Pathway
Upstream Targets in the p53 Pathway
McCarthy, Anna R.; Lain, Sonia
or wild-type ...
... viability and subtle developmental defects of  p53 
Embryonic stem cells shed new light on the developmental roles of p53
Embryonic stem cells shed new light on the developmental roles of p53
Shin, Min Hwa; He, Yunlong; Huang, Jing
knockout mice suggest that ...
... Background The tumor suppressor protein  p53 
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
Loewer, Alexander; Karanam, Ketki; Mock, Caroline; Lahav, Galit
is activated by cellular stress. ...
... The  p53 
p53: Guardian of the Metabolome
p53: Guardian of the Metabolome
Poyurovsky, Masha V.; Prives, Carol
tumor suppressor protein is critically important ...
... The well-known transcription factor  p53 
Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury
Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury
Kim, Young-Ae; Kim, Mi-Young; Yu, Hye Yon; Mishra, Siddhartha Kumar; Lee, Jae-Hyeok; Choi, Kyeong Sook; Kim, Jae-Ho; Xiang, Yang Kevin; Jung, Yi-Sook
is known to cause apoptosis in cardiomyocytes ...
... Background The  p53 
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Wachter, Franziska; Grunert, Michaela; Blaj, Cristina; Weinstock, David M; Jeremias, Irmela; Ehrhardt, Harald
protein is the best studied target in human ...
... expression, carry a missense mutation at the  p53 
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Gottschalk, Benjamin; Klein, Andreas
codon 242 (mouse G242 corresponds to human hot ...
... Background The  p53 
Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
Hafsi, Hind; Santos-Silva, Daniela; Courtois-Cox, Stéphanie; Hainaut, Pierre
protein is expressed as multiple isoforms that ...
... Background The  p53 
PintlincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
PintlincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
Marín-Béjar, Oskar; Marchese, Francesco P; Athie, Alejandro; Sánchez, Yolanda; González, Jovanna; Segura, Victor; Huang, Lulu; Moreno, Isabel; Navarro, Alfons; Monzó, Mariano; García-Foncillas, Jesús; Rinn, John L; Guo, Shuling; Huarte, Maite
transcription factor is located at the core of a ...
... attenuates the function of the tumor suppressor  p53 
Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels
Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels
Schilling, Daniela; Düwel, Michael; Molls, Michael; Multhoff, Gabriele
. ...
...  p53 
Targeting p53 by small molecules in hematological malignancies
Targeting p53 by small molecules in hematological malignancies
Saha, Manujendra N; Qiu, Lugui; Chang, Hong
is a powerful tumor suppressor and is an ...
... but arbitrarily selected multiscale part of the  p53 
Direct Computer Mapping Based Modeling of a Multiscale Process Involving p53/miR-34a Signaling
Direct Computer Mapping Based Modeling of a Multiscale Process Involving p53/miR-34a Signaling
Csukás, Béla; Varga, Mónika; Prokop, Aleš
/miR-34a related signaling process that has an ...