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... Background The  p53 
Impact of Alu repeats on the evolution of human p53 binding sites
Impact of Alu repeats on the evolution of human p53 binding sites
Cui, Feng; Sirotin, Michael V; Zhurkin, Victor B
tumor suppressor protein is involved in a ...
...  p53 
Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
Regeling, Anouk; Armata, Heather L.; Gallant, Judy; Jones, Stephen N.; Sluss, Hayla K.
is a major suppressor of human malignancy. ...
... no curative treatments. While mutation of the  P53 
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
Avery-Kiejda, Kelly A; Bowden, Nikola A; Croft, Amanda J; Scurr, Lyndee L; Kairupan, Carla F; Ashton, Katie A; Talseth-Palmer, Bente A; Rizos, Helen; Zhang, Xu D; Scott, Rodney J; Hersey, Peter
tumour suppressor gene is a common feature of ...
... reactivity against the tumor suppressor protein  p53 
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
Met, Özcan; Balslev, Eva; Flyger, Henrik; Svane, Inge Marie
in breast cancer patients (BCP) at the time point ...
... the wild-type (wt) form of the tumor suppressor  p53 
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
Wang, Fei; Liu, Jianfeng; Robbins, Delira; Morris, Kerri; Sit, Amos; Liu, Yong-Yu; Zhao, Yunfeng
, can translocate to mitochondria due to ...
... One of the key regulators of the DDR is  p53 
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
Valentine, Jane M; Kumar, Sonia; Moumen, Abdeladim
, itself tightly regulated by MDM2. ...
... we explore the modifications and activation of  p53 
Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin
Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin
Illuzzi, Jennifer L.; Vickers, Cassie A.; Kmiec, Eric B.
and keystone regulators of the cell stress ...
... on apoptosis induction in wild-type and mutant  p53 
Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells
Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells
Stravopodis, Dimitrios J.; Karkoulis, Panagiotis K.; Konstantakou, Eumorphia G.; Melachroinou, Sophia; Thanasopoulou, Angeliki; Aravantinos, Gerasimos; Margaritis, Lukas H.; Anastasiadou, Ema; Voutsinas, Gerassimos E.
urinary bladder cancer cells. ...
... mediated pathway with subsequent inactivation of  p53 
A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation
A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation
Brekman, Angelika; Singh, Kathryn E; Polotskaia, Alla; Kundu, Nandini; Bargonetti, Jill
. ...
... apoptosis, we conditionally deleted one allele of  p53 
Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation
Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation
Kotb, Ahmed M; Hierholzer, Andreas; Kemler, Rolf
in Ncadk.i. mice and observed a temporal rescue ...
... (NSCLC). Gene copy number was analyzed by qPCR.  P53 
P53 suppresses expression of the 14-3-3gamma oncogene
P53 suppresses expression of the 14-3-3gamma oncogene
Radhakrishnan, Vijayababu M; Putnam, Charles W; Qi, Wenqing; Martinez, Jesse D
mutations were detected by direct sequencing and ...
... tumor suppressor gene and its protein product  p53 
The Role of the Nucleolus in the Stress Response
The Role of the Nucleolus in the Stress Response
Tollini, Laura A.; Frum, Rebecca A.; Zhang, Yanping
, play a critical role in the cellular stress ...
... associated with Epstein-Barr virus infection. The  p53 
Epstein-Barr virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway
Epstein-Barr virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway
Husaini, Roslina; Ahmad, Munirah; Soo-Beng Khoo, Alan
tumour suppressor protein is rarely mutated in ...
... The  p53 
Small-Molecule Inhibitors of the p53-MDM2 Interaction
Small-Molecule Inhibitors of the p53-MDM2 Interaction
Vu, Binh T.; Vassilev, Lyubomir
tumor suppressor is controlled by MDM2, which ...
... Introduction Normal function of the  p53 
p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
Bourdon, Jean-Christophe; Khoury, Marie P; Diot, Alexandra; Baker, Lee; Fernandes, Kenneth; Aoubala, Mustapha; Quinlan, Philip; Purdie, Colin A; Jordan, Lee B; Prats, Anne-Catherine; Lane, David P; Thompson, Alastair M
network is lost in most cancers, often through ...
... a vital role in diseases such as cancer, and that  p53 
Metabolic regulation by p53
Metabolic regulation by p53
Maddocks, Oliver D. K.; Vousden, Karen H.
is an important regulator of metabolic pathways. ...
... In this study, we studied the effects of  p53 
p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells
p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells
Wang, Mei-Juan; Pei, Dong-Sheng; Qian, Guo-Wei; Yin, Xiao-Xing; Cheng, Qian; Li, Lian-Tao; Li, Hui-Zhong; Zheng, Jun-Nian
on Ki-67 promoter in HeLa cells using luciferase ...
...  p53 
Insulin receptor signaling activated by penta-O-galloyl-α-d-glucopyranose induces p53 and apoptosis in cancer cells
Insulin receptor signaling activated by penta-O-galloyl-α-d-glucopyranose induces p53 and apoptosis in cancer cells
Cao, Yanyan; Evans, Susan C.; Soans, Eroica; Malki, Ahmed; Liu, Yi; Liu, Yan; Chen, Xiaozhuo
is essential for cell cycle arrest and apoptosis ...
... 50% of all human cancers the tumor suppressor  p53 
Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts
Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts
Lenos, Kristiaan; de Lange, Job; Teunisse, Amina FAS; Lodder, Kirsten; Verlaan-de Vries, Matty; Wiercinska, Eliza; van der Burg, Marja JM; Szuhai, Karoly; Jochemsen, Aart G
is mutated. ...
... Most tumor cells due to disruptions in the  p53 
Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling
Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling
Thomas, Christoforos G.; Strom, Anders; Lindberg, Karolina; Gustafsson, Jan-Ake
-dependent G1 pathway are dependent on S-phase ...
... The tumor-suppressor  p53 
Osteocalcin Gene Expression Is Regulated by Wild-Type p53
Osteocalcin Gene Expression Is Regulated by Wild-Type p53
Chen, Hankui; Hays, Emily; Liboon, Jay; Neely, Chris; Kolman, Kevin; Chandar, Nalini
is a transcription factor that regulates a number ...
... be drawn between the classical tumour suppressor  p53 
Nuclear Subdomains and Cancer
Nuclear Subdomains and Cancer
Cann, Kendra L.; Huang, Sui; Dellaire, Graham
and PML. ...
... that govern cell survival. It phosphorylates  p53 
Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma
Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma
Liu, Qingjun; Mier, James W; Panka, David J
, for example, and induces its nuclear export, ...
... Various DNA-targeting agents may initiate  p53 
Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells
Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells
Rudolf, E.; Rudolf, K.; Cervinka, M.
-dependent as well as ...
... focused our analysis on the modulation of the  p53 
Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
Terrier, Olivier; Josset, Laurence; Textoris, Julien; Marcel, Virginie; Cartet, Gaëlle; Ferraris, Olivier; N'Guyen, Catherine; Lina, Bruno; Diaz, Jean-Jacques; Bourdon, Jean-Christophe; Rosa-Calatrava, Manuel
pathway in response to influenza infection. ...

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