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... Background MCT-1 oncoprotein accelerates  p53 
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Kasiappan, Ravi; Shih, Hung-Ju; Wu, Meng-Hsun; Choy, ChikOn; Lin, Tai-Du; Chen, Linyi; Hsu, Hsin-Ling
protein degradation via a proteosome pathway. ...
... of Alzheimer's disease. The transcription factor,  p53 
GSK3 and p53 - is there a link in Alzheimer's disease?
GSK3 and p53 - is there a link in Alzheimer's disease?
Proctor, Carole J; Gray, Douglas A
also plays a role and has been linked to an ...
...  p53 
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Giono, Luciana E.; Manfredi, James J.
is a widely conserved tumor suppressor protein ...
... The  p53 
p53
p53
Tsai, Wen-Wei; Barton, Michelle Craig
tumor suppressor is well known as the major ...
... Background  p53 
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Ajay, Amrendra K; Upadhyay, Ankur K; Singh, Sandeep; Vijayakumar, Maleppillil V; Kumari, Ratna; Pandey, Vimal; Boppana, Ramanamurthy; Bhat, Manoj K
is the most studied tumor suppressor and its ...
...  p53 
Regulation of tumor suppressor p53 at the RNA level
Regulation of tumor suppressor p53 at the RNA level
Vilborg, Anna; Wilhelm, Margareta T.; Wiman, Klas G.
is a key tumor suppressor that triggers cell ...
... Recent work has shown that the basal level of  p53 
p53 regulates LIF expression in human medulloblastoma cells
p53 regulates LIF expression in human medulloblastoma cells
Baxter, Euan W.; Milner, Jo
plays an important role in maternal reproduction ...
... ligament cells via a pathway that requires  p53 
Anoikis triggers Mdm2-dependent p53 degradation
Anoikis triggers Mdm2-dependent p53 degradation
Ghosh, Abhijit; Chen, Tina Chunyuan; Kapila, Yvonne L.
transcriptional downregulation. ...
... It is ironic that the  p53 
Tumor Suppressor p53: A Multifunctional Protein Implicated in Seizure-Induced Neuronal Cell Death
Tumor Suppressor p53: A Multifunctional Protein Implicated in Seizure-Induced Neuronal Cell Death
Tan, Zhiqun; Schreiber, Steven S.
“tumor antigen”, first discovered more than 20 ...
... The tumor suppressor  p53 
The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network
The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network
Boominathan, Lakshmanane
homologues, TA-p73, and p63 have been shown to ...
... for R at this codon. The wild-type sequence (wt)  p53 
CD8+ T cell recognition of polymorphic wild-type sequence p5365–73 peptides in squamous cell carcinoma of the head and neck
CD8+ T cell recognition of polymorphic wild-type sequence p5365–73 peptides in squamous cell carcinoma of the head and neck
Andrade Filho, Pedro A.; Ito, Daisuke; DeLeo, Albert B.; Ferris, Robert L.
peptide, p5365–73, has been identified as a CD8+ ...
... studies demonstrated that Meq is able to bind  p53 
The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities
The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities
Deng, Xufang; Li, Xiangdong; Shen, Yang; Qiu, Yafeng; Shi, Zixue; Shao, Donghua; Jin, Yamei; Chen, Hongjun; Ding, Chan; Li, Li; Chen, Puyan; Ma, Zhiyong
in vitro, as demonstrated using a protein-binding ...
... microarray gene expression data. By using the  p53 
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Wang, Junbai; Tian, Tianhai
network as a test system, we used the nonlinear ...
... all human cancers carry direct mutations of the  p53 
p53 and Angiogenesis
p53 and Angiogenesis
Teodoro, Jose G.; Evans, Sara K.; Green, Michael R.
coding region. ...
... Background The  p53 
Stress-specific response of the p53-Mdm2 feedback loop
Stress-specific response of the p53-Mdm2 feedback loop
Hunziker, Alexander; Jensen, Mogens H; Krishna, Sandeep
signalling pathway has hundreds of inputs and ...
... Background P16 and  p53 
Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer
Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer
Smith, Elaine M; Rubenstein, Linda M; Hoffman, Henry; Haugen, Thomas H; Turek, Lubomir P
protein expression, and high-risk human ...
... Background and Objectives The  p53 
p53 Mutation Status Predicts Pathological Response to Chemoradiotherapy in Locally Advanced Esophageal Cancer
p53 Mutation Status Predicts Pathological Response to Chemoradiotherapy in Locally Advanced Esophageal Cancer
Makino, Tomoki; Yamasaki, Makoto; Miyata, Hiroshi; Yoshioka, Setsuko; Takiguchi, Shuji; Fujiwara, Yoshiyuki; Nakajima, Kiyokazu; Nishida, Toshirou; Mori, Masaki; Doki, Yuichiro
gene promotes cell-cycle arrest and apoptosis ...
... and δ) to phosphorylate the N-terminal region of  p53 
Isoform specific phosphorylation of p53 by protein kinase CK1
Isoform specific phosphorylation of p53 by protein kinase CK1
Venerando, Andrea; Marin, Oriano; Cozza, Giorgio; Bustos, Victor H.; Sarno, Stefania; Pinna, Lorenzo Alberto
has been assessed using either recombinant ...
... The tumor suppressor  p53 
Antisense RNA-Mediated Regulation of the p53 Tumor Suppressor
Antisense RNA-Mediated Regulation of the p53 Tumor Suppressor
Farnebo, Marianne; Wiman, Klas G.
triggers cell death by apoptosis in response to ...
... The tumor suppressor  p53 
The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions
The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions
Feng, Zhaohui; Levine, Arnold J.
plays an important role in maintaining genomic ...
... of the MCP-1 upstream region proposed a putative  p53 
Regulation of MCP-1 chemokine transcription by p53
Regulation of MCP-1 chemokine transcription by p53
Hacke, Katrin; Rincon-Orozco, Bladimiro; Buchwalter, Gilles; Siehler, Simone Y.; Wasylyk, Bohdan; Wiesmüller, Lisa; Rösl, Frank
binding side about 2.5 kb upstream of the ...
... identified a putative response element for the  p53 
Induction of the small heat shock protein αB-crystallin by genotoxic stress is mediated by p53 and p73
Induction of the small heat shock protein αB-crystallin by genotoxic stress is mediated by p53 and p73
Evans, Joseph R.; Bosman, Joshua D.; Brown-Endres, Lauren; Yehiely, Fruma; Cryns, Vincent L.
tumor suppressor protein. ...
... focuses on replacement therapies for abnormal  p53 
Tumor Suppressor Gene Therapy
Tumor Suppressor Gene Therapy
Roth, Jack A.; Nemunaitis, John; Ji, Lin; Ramesh, Rajagopal
function and FUS1 tumor suppressor gene-mediated ...
... double minute 2 (MDM2) is a negative regulator of  p53 
Associations of MDM2 SNP309, Transcriptional Activity, mRNA Expression, and Survival in Stage I Non-Small-Cell Lung Cancer Patients with Wild-Type p53 Tumors
Associations of MDM2 SNP309, Transcriptional Activity, mRNA Expression, and Survival in Stage I Non-Small-Cell Lung Cancer Patients with Wild-Type p53 Tumors
Chien, Wen-Pin; Wong, Ruey-Hong; Cheng, Ya-Wen; Chen, Chih-Yi; Lee, Huei
. ...
... Results We show that the transcription factor  p53 
High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-κB-complex-dependent gene expression in human heart failure
High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-κB-complex-dependent gene expression in human heart failure
Choy, Mun-Kit; Movassagh, Mehregan; Siggens, Lee; Vujic, Ana; Goddard, Martin; Sánchez, Ana; Perkins, Neil; Figg, Nichola; Bennett, Martin; Carroll, Jason; Foo, Roger
piggy-backs onto NF-κB/RELA and utilizes the ...

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