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... Understanding the mechanism underlying  p53 
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... Mutations in the TP53 gene or the  p53 
p53 Pathway Alterations in Brain Tumors
p53 Pathway Alterations in Brain Tumors
Yin, Shaoman; Van Meir, Erwin G.
pathway are required for the formation of many ...
... Background Activation of  p53 
HIPK2 modulates p53 activity towards pro-apoptotic transcription
HIPK2 modulates p53 activity towards pro-apoptotic transcription
Puca, Rosa; Nardinocchi, Lavinia; Sacchi, Ada; Rechavi, Gideon; Givol, David; D'Orazi, Gabriella
-mediated gene transcription is a critical ...
... Purpose  p53 
Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment
Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment
Kraljević Pavelić, Sandra; Marjanović, Marko; Poznić, Miroslav; Kralj, Marijeta
gene plays a crucial role in the response to ...
... a variety of human cancers containing the mutant  p53 
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism
Hori, Makoto; Suzuki, Keiji; Udono, Masako U.; Yamauchi, Motohiro; Mine, Mariko; Watanabe, Masami; Kondo, Shigeo; Hozumi, Yutaka
(mt- ...
...  p53 
Targeting p53 for enhanced radio- and chemo-sensitivity
Targeting p53 for enhanced radio- and chemo-sensitivity
Lu, Chao; El-Deiry, Wafik S.
acts as a central mediator of the cellular ...
... The tumor suppressor  p53 
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif
Worrall, Erin G.; Wawrzynow, Bartosz; Worrall, Liam; Walkinshaw, Malcolm; Ball, Kathryn L.; Hupp, Ted R.
has evolved a MDM2-dependent feedback loop that ...
... Background The  p53 
Regression based predictor for p53 transactivation
Regression based predictor for p53 transactivation
Gowrisankar, Sivakumar; Jegga, Anil G
protein is a master regulator that controls the ...
... Wild-type sequence (wt)  p53 
CD4+ T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head and neck cancer
CD4+ T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head and neck cancer
Chikamatsu, Kazuaki; Sakakura, Koichi; Takahashi, Goro; Okamoto, Atsushi; Furuya, Nobuhiko; Whiteside, Theresa L.; DeLeo, Albert B.; Masuyama, Keisuke
peptides are attractive candidates for broadly ...
... Background The tumor suppressor  p53 
Modeling the role of p53 pulses in DNA damage- induced cell death decision
Modeling the role of p53 pulses in DNA damage- induced cell death decision
Sun, Tingzhe; Chen, Chun; Wu, Yuanyuan; Zhang, Shuai; Cui, Jun; Shen, Pingping
plays pivotal roles in tumorigenesis ...
... Background Accumulated evidence suggests that  p53 
Potential Increase in the Prognostic Value of p53 Mutation by Pro72 Allele in Stage I Non-Small-Cell Lung Cancer
Potential Increase in the Prognostic Value of p53 Mutation by Pro72 Allele in Stage I Non-Small-Cell Lung Cancer
Chien, Wen-Pin; Wong, Ruey-Hong; Wu, Tsu-Chin; Cheng, Ya-Wen; Chen, Chih-Yi; Lee, Huei
function altered by its gene mutation or genetic ...
... Mutational inactivation of the tumour suppressor  p53 
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
Kang, Khong Bee; Zhu, Congju; Yong, Sook Kwin; Gao, Qiuhan; Wong, Meng Cheong
gene is frequent in malignant gliomas. ...
... we demonstrate that Sgk1 activates MDM2-dependent  p53 
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation
Amato, Rosario; D’Antona, Lucia; Porciatti, Giovanni; Agosti, Valter; Menniti, Miranda; Rinaldo, Cinzia; Costa, Nicola; Bellacchio, Emanuele; Mattarocci, Stefano; Fuiano, Giorgio; Soddu, Silvia; Paggi, Marco G.; Lang, Florian; Perrotti, Nicola
ubiquitylation. ...
... The tumor suppressor  p53 
Drug Resistance and the Tumor Suppressor p53: The Paradox of Wild-Type Genotype in Chemorefractory Cancers
Drug Resistance and the Tumor Suppressor p53: The Paradox of Wild-Type Genotype in Chemorefractory Cancers
Siddik, Zahid H.
has a central role in drug-induced cell death. ...
... to the development and progression of cancer. The  p53 
The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death
The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death
Chari, Nikhil S.; Pinaire, Nicole L.; Thorpe, Lynnelle; Medeiros, L. Jeffrey; Routbort, Mark J.; McDonnell, Timothy J.
tumor suppressor protein is among the most ...
... by expression plasmids that encode mutant  p53 
DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis
DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis
Humar, Matjaz; Maurer, Martina; Azemar, Marc; Groner, Bernd
was conducted to characterize exogenously induced ...
... Abstract Background The  p53 
Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
Huang, Vera; Lu, Xin; Jiang, Yong; Wang, Jean YJ
tumor suppressor and its related protein, p73, ...
... and aberrant proliferative signals. The  p53 
Regulation of p53 Activity and Associated Checkpoint Controls
Regulation of p53 Activity and Associated Checkpoint Controls
Post, Sean M.; Quintás-Cardama, Alfonso; Lozano, Guillermina
tumor suppressor encodes one such checkpoint ...
... Background  P53 
Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage
Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage
Solozobova, Valeriya; Rolletschek, Alexandra; Blattner, Christine
is a key tumor suppressor protein. ...
... decreased. Upon camptothecin treatment, levels of  p53 
Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent
Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent
Wu, Chia-Yen; Gómez-Curet, Ilsa; Funanage, Vicky L; Scavina, Mena; Wang, Wenlan
were markedly increased. ...
... The prevalence in human cancers of mutations in  p53 
GSK3β N-terminus binding to p53 promotes its acetylation
GSK3β N-terminus binding to p53 promotes its acetylation
Eom, Tae-Yeon; Jope, Richard S
exemplifies its crucial role as a tumor ...
... Background  p53 
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
Dong, Peixin; Xu, Zhujie; Jia, Nan; Li, Dajin; Feng, Youji
is the most commonly mutated tumor suppressor ...
... epidemiological data. The Smoking-PAH-BPDE-  p53 
Estimating the Fraction of Disease Caused by One Component of a Complex Mixture: Bounds for Lung Cancer
Estimating the Fraction of Disease Caused by One Component of a Complex Mixture: Bounds for Lung Cancer
Cox, Louis Anthony, Jr
-Lung Cancer Causal Pathway Figure 8.1 outlines ...
... Inactivation of tumor suppressor  p53 
Disruption of estrogen receptor α-p53 interaction in breast tumors: a novel mechanism underlying the anti-tumor effect of radiation therapy
Disruption of estrogen receptor α-p53 interaction in breast tumors: a novel mechanism underlying the anti-tumor effect of radiation therapy
Liu, Wensheng; Ip, Margot M.; Podgorsak, Matthew B.; Das, Gokul M.
is one of the most frequent events in cancer. ...
... As a tumor suppressor,  p53 
Molecular dynamics simulation of S100B protein to explore ligand blockage of the interaction with p53 protein
Molecular dynamics simulation of S100B protein to explore ligand blockage of the interaction with p53 protein
Zhou, Zhigang; Li, Yumin
plays an important role in cancer suppression. ...

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