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...  p53 
Exonucleolytic degradation of RNA by p53 protein in cytoplasm
Exonucleolytic degradation of RNA by p53 protein in cytoplasm
Bakhanashvili, Mary; Gedelovich, Rachel; Grinberg, Shai; Rahav, Galia
in cytoplasm displays an intrinsic 3′→5′ ...
... The human mutant  p53 
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Duan, Wenrui; Gao, Li; Jin, David; Otterson, Gregory A.; Villalona-Calero, Miguel A.
(273H) has been shown in vitro to have both ...
... Background The tumor suppressor protein  p53 
p53 induces distinct epigenetic states at its direct target promoters
p53 induces distinct epigenetic states at its direct target promoters
Vrba, Lukas; Junk, Damian J; Novak, Petr; Futscher, Bernard W
is a transcription factor that is mutated in many ...
... of cancer cells. However, the contribution of  p53 
Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis
Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis
Lahiry, Lakshmishri; Saha, Baisakhi; Chakraborty, Juni; Bhattacharyya, Sankar; Chattopadhyay, Sreya; Banerjee, Shuvomoy; Choudhuri, Tathagata; Mandal, Debaprasad; Bhattacharyya, Arindam; Sa, Gaurisankar; Das, Tanya
in mammary epithelial carcinoma cell apoptosis by ...
... the second as backup. Not necessarily so with  p53 
Resistance of mitochondrial p53 to dominant inhibition
Resistance of mitochondrial p53 to dominant inhibition
Heyne, Kristina; Schmitt, Katrin; Mueller, Daniel; Armbruester, Vivienne; Mestres, Pedro; Roemer, Klaus
. ...
... Background The master regulator  p53 
Dissecting microregulation of a master regulatory network
Dissecting microregulation of a master regulatory network
Sinha, Amit U; Kaimal, Vivek; Chen, Jing; Jegga, Anil G
tumor-suppressor protein through coordination of ...
... No abstract available 1 The  p53 
p53 Inhibitors as Cancer Sensitizing Agents
p53 Inhibitors as Cancer Sensitizing Agents
Maina, Flavio; Dono, Rosanna
Player: A Stage Director for the Fate of Stressed ...
... Background The tumour suppressor protein  p53 
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
Bereczki, Orsolya; Ujfaludi, Zsuzsanna; Pardi, Norbert; Nagy, Zita; Tora, Laszlo; Boros, Imre M; Balint, Eva
is a sequence specific DNA-binding transcription ...
... process was described. Wild type full-length  p53 
Simplified approaches for the development of an ELISA to detect circulating autoantibodies to p53 in cancer patients
Simplified approaches for the development of an ELISA to detect circulating autoantibodies to p53 in cancer patients
Cressey, Ratchada; Pimpa, Saranya; Chewaskulyong, Busyamas; Lertprasertsuke, Nirush; Saeteng, Somchareon; Tayapiwatana, Chatchai; Kasinrerk, Watchara
protein was produced in fusion with biotin ...
... Background PNC-27 and PNC-28 are  p53 
The Penetratin Sequence in the Anticancer PNC-28 Peptide Causes Tumor Cell Necrosis Rather Than Apoptosis of Human Pancreatic Cancer Cells
The Penetratin Sequence in the Anticancer PNC-28 Peptide Causes Tumor Cell Necrosis Rather Than Apoptosis of Human Pancreatic Cancer Cells
Bowne, Wilbur B.; Sookraj, Kelley A.; Vishnevetsky, Michael; Adler, Victor; Sarafraz-Yazdi, Ehsan; Lou, Sunming; Koenke, Jesco; Shteyler, Vadim; Ikram, Kamran; Harding, Michael; Bluth, Martin H.; Ng, Mou; Brandt-Rauf, Paul W.; Hannan, Raqibul; Bradu, Stephan; Zenilman, Michael E.; Michl, Josef; Pincus, Matthew R.
-derived peptides from the human double minute ...
... Background  p53 
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine
Reed, Karen R; Meniel, Valerie S; Marsh, Victoria; Cole, Alicia; Sansom, Owen J; Clarke, Alan R
is an important tumour suppressor with a known ...
... Background In individual living cells  p53 
Explaining oscillations and variability in the p53-Mdm2 system
Explaining oscillations and variability in the p53-Mdm2 system
Proctor, Carole J; Gray, Douglas A
has been found to be expressed in a series of ...
... The tumor suppressor  p53 
Biochemical and Functional Evidence of p53 Homology Is Inconsistent with Molecular Phylogenetics for Distant Sequences
Biochemical and Functional Evidence of p53 Homology Is Inconsistent with Molecular Phylogenetics for Distant Sequences
Fernandes, Andrew D.; Atchley, William R.
is mutated in ∼50% of all human cancer cases ...
... of protein complexes that contained GST-tagged  p53 
Study on the Spatial Architecture of p53, MDM2, and p14ARF Containing Complexes
Study on the Spatial Architecture of p53, MDM2, and p14ARF Containing Complexes
Savchenko, Andrej; Yurchenko, Mariya; Snopok, Boris; Kashuba, Elena
, p14ARF, and MDM2 was examined by the developed ...
...  p53 
A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization
A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization
Xu, G. Wei; Mawji, Imtiaz A.; Macrae, Chloe J.; Koch, C. Anne; Datti, Alessandro; Wrana, Jeffrey L.; Dennis, James W.; Schimmer, Aaron D.
regulates apoptosis and the cell cycle through ...
... is as common as genetic mutations in  p53 
DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16ink4A down-regulation
DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16ink4A down-regulation
Guo, Zhanjun; Tsai, Mong-Hsun; Shiao, Yih-Horng; Chen, Li-Han; Wei, Mei-Ling; Lv, Xing; Gius, David; Little, John B.; Mitchell, James B.; Chuang, Eric Y.
. ...
... element to detect tumor suppressor protein  p53 
Molecular biosensing system based on intrinsically disordered proteins
Molecular biosensing system based on intrinsically disordered proteins
Cissell, Kyle A.; Shrestha, Suresh; Purdie, Jennifer; Kroodsma, Derrick; Deo, Sapna K.
through the BRCA1/ ...
... self-ubiquitination, and the stabilization of  p53 
Ubiquitin over-expression promotes E6AP autodegradation and reactivation of the p53/MDM2 pathway in HeLa cells
Ubiquitin over-expression promotes E6AP autodegradation and reactivation of the p53/MDM2 pathway in HeLa cells
Crinelli, Rita; Bianchi, Marzia; Menotta, Michele; Carloni, Elisa; Giacomini, Elisa; Pennati, Marzia; Magnani, Mauro
. ...
... Background Although mutations in the  p53 
Clinical Significance of P53 Protein Expression in Papillary Thyroid Carcinoma
Clinical Significance of P53 Protein Expression in Papillary Thyroid Carcinoma
Morita, Naomi; Ikeda, Yoshifumi; Takami, Hiroshi
suppressor gene in thyroid carcinoma have usually ...
... is the ability of E6 proteins to target cellular  p53 
Comparison of p53 and the PDZ domain containing protein MAGI-3 regulation by the E6 protein from high-risk human papillomaviruses
Comparison of p53 and the PDZ domain containing protein MAGI-3 regulation by the E6 protein from high-risk human papillomaviruses
Ainsworth, Julia; Thomas, Miranda; Banks, Lawrence; Coutlee, Francois; Matlashewski, Greg
and proteins containing PDZ domains, including ...
... The Wild-type  p53 
The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways
The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways
Lu, Xiongbin; Nguyen, Thuy-Ai; Moon, Sung-Hwan; Darlington, Yolanda; Sommer, Matthias; Donehower, Lawrence A.
-induced phosphatase 1, Wip1 (or PPM1D), is ...
... Objectives Our objectives were to compare  p53 
Fluorescence in situ Hybridization and Immunohistochemical Analysis of p53 Expression in Endometrial Cancer: Prognostic Value and Relation to Ploidy
Fluorescence in situ Hybridization and Immunohistochemical Analysis of p53 Expression in Endometrial Cancer: Prognostic Value and Relation to Ploidy
Graesslin, Olivier; Chantot-Bastaraud, Sandra; Lorenzato, Marianne; Birembaut, Philippe; Quéreux, Christian; Daraï, Emile
immunohistochemical expression with ...
... Many studies have revealed the frequency of  p53 
Predictive Value of Measuring p53 Labeling Index at the Invasive Front of Oral Squamous Cell Carcinomas
Predictive Value of Measuring p53 Labeling Index at the Invasive Front of Oral Squamous Cell Carcinomas
Kato, Koroku; Kawashiri, Shuichi; Tanaka, Akira; Noguchi, Natsuyo; Nakaya, Hiromitsu; Hase, Takashi; Yamamoto, Etsuhide
abnormalities in oral cancer. ...
... Modulation of the activity of tumor suppressor  p53 
In GFP with high risk HPV-18E6 fusion protein expressed 293T and MCF-7 cells, the endogenous wild-type p53 could be transiently phosphorylated at multiple sites
In GFP with high risk HPV-18E6 fusion protein expressed 293T and MCF-7 cells, the endogenous wild-type p53 could be transiently phosphorylated at multiple sites
Sun, Lina; Zhang, Ge; Li, Zongfang; Song, Tusheng; Huang, Chen; Si, Lusheng
is a key event in the replication of many ...
... are disrupted in medulloblastoma. Wild-type  p53 
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D
Castellino, Robert C.; Bortoli, Massimiliano; Lu, Xiongbin; Moon, Sung-Hwan; Nguyen, Thuy-Ai; Shepard, Mark A.; Rao, Pulivarthi H.; Donehower, Lawrence A.; Kim, John Y. H.
-induced phosphatase 1 (WIP1 or PPM1D) encodes a ...