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... Background  p53 
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
Brynczka, Christopher; Labhart, Paul; Merrick, B Alex
is recognized as a critical regulator of the cell ...
... linked at the molecular level. Results Blocking  p53 
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Villiard, Éric; Brinkmann, Henner; Moiseeva, Olga; Mallette, Frédérick A; Ferbeyre, Gerardo; Roy, Stéphane
signaling in axolotls using the ...
... not fully understood. The presence of wild type  p53 
Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation
Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation
Bragado, Paloma; Armesilla, Alejandro; Silva, Augusto; Porras, Almudena
has been suggested to be important for cisplatin ...
... of FGF1 and the pro-apoptotic activity of  p53 
Fibroblast Growth Factor 1 inhibits p53-dependent apoptosis in PC12 cells
Fibroblast Growth Factor 1 inhibits p53-dependent apoptosis in PC12 cells
Bouleau, Sylvina; Pârvu-Ferecatu, Ioana; Rodriguez-Enfedaque, Aida; Rincheval, Vincent; Grimal, Hélène; Mignotte, Bernard; Vayssiere, Jean-Luc; Renaud, Flore
were characterized in vitro and/or in vivo for ...
... Tumor-specific alterations at the  p53 
Loss of heterozygosity of the p53 gene and deregulated expression of its mRNA and protein in human brain tumors
Loss of heterozygosity of the p53 gene and deregulated expression of its mRNA and protein in human brain tumors
Rohini, K.; Mathivanan, J.; Antony Herold Prabhu, P. D.; Subbakrishna, D. K.; Gope, M. L.; Chandramouli, B. A.; Sampath, S.; Anandh, B.; Gope, R.
gene locus were analyzed in 40 human brain tumor ...
... Background The cellular regulatory protein  p53 
An MVA vaccine overcomes tolerance to human p53 in mice and humans
An MVA vaccine overcomes tolerance to human p53 in mice and humans
Song, Guang-Yun; Gibson, Glen; Haq, Wahajul; Huang, Eric C. C.; Srivasta, Tumul; Hollstein, Monica; Daftarian, Pirouz; Wang, Zhongde; Diamond, Don; Ellenhorn, Joshua D. I.
is overexpressed by almost 50% of all ...
... elements in the coding region and a putative  p53 
Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells
Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells
Pratt, M. A. Christine; White, Dawn; Kushwaha, Neena; Tibbo, Emma; Niu, Min Ying
negative regulatory element (NRE) containing a ...
... distinguished cancer cell subsets associated with  p53 
Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma
Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma
Yan, Bin; Yang, Xinping; Lee, Tin-Lap; Friedman, Jay; Tang, Jun; Van Waes, Carter; Chen, Zhong
status. ...
... transcriptional activity of the tumor suppressor  p53 
Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways
Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways
Ding, Vivianne W.; Lin, Li-Ping; Chiang, Andrew L.; McCormick, Frank
. ...
... previously reported that the transcription factor  p53 
The Glial Response to CNS HIV Infection Includes p53 Activation and Increased Expression of p53 Target Genes
The Glial Response to CNS HIV Infection Includes p53 Activation and Increased Expression of p53 Target Genes
Jayadev, Suman; Yun, Bomy; Nguyen, Huy; Yokoo, Hideaki; Morrison, Richard S.; Garden, Gwenn A.
accumulates in neurons, microglia, and astrocytes ...
... yet a possible role of FasL expression in  p53 
Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model system
Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model system
Okazaki, Toshihiko; Sakamuro, Daitoku
-dependent apoptosis is not fully understood in ...
... To study on the antitumor effect of combining wt-  p53 
Exogenous wt-p53 enhances the antitumor effect of HSV-TK/GCV on C6 glioma cells
Exogenous wt-p53 enhances the antitumor effect of HSV-TK/GCV on C6 glioma cells
Huang, Qiang; Pu, Peiyu; Xia, Zhibo; You, Yongping
gene with suicide gene therapy (HSV-tk+GCV) for ...
... The  p53 
Early diversification and complex evolutionary history of the p53 tumor suppressor gene family
Early diversification and complex evolutionary history of the p53 tumor suppressor gene family
Nedelcu, Aurora M.; Tan, Christopher
tumor suppressor plays the leading role in ...
... negative (DN) mutations of tumor suppressor  p53 
p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells
p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells
Dong, Peixin; Tada, Mitsuhiro; Hamada, Jun-Ichi; Nakamura, Akihiro; Moriuchi, Tetsuya; Sakuragi, Noriaki
(TP53) are clinically associated with cancer ...
... The  p53 
Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome
Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome
Teodoro, Jose G.; Evans, Sara K.; Green, Michael R.
tumor suppressor protein has long been recognized ...
...  p53 
Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes
Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes
Long, Xilin; Goldenthal, Michael J.; Marín-García, José
is an important regulator of cell growth and ...
...  p53 
Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers
Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers
Svane, Inge Marie; Pedersen, Anders E.; Johansen, Julia S.; Johnsen, Hans E.; Nielsen, Dorte; Kamby, Claus; Ottesen, Svend; Balslev, Eva; Gaarsdal, Eva; Nikolajsen, Kirsten; Claesson, Mogens H.
mutations are found in up to 30% of breast ...
... PI3k-Akt and  p53 
Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling
Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling
Zhirnov, Oleg P.; Klenk, Hans-Dieter
pathways are known to play anti- and ...
... Down-regulation of  p53 
The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells
The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells
Yang, Di; Qi, Yitao; Chen, Qian; Wang, Zhiqin; Jin, Xi; Gao, Jie; Fu, Juanling; Xiao, Xilong; Zhou, Zongcan
expression has been found in a broad range of ...
... a transcriptional profile indicative of increased  p53 
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
Edwards, Michael G; Anderson, Rozalyn M; Yuan, Ming; Kendziorski, Christina M; Weindruch, Richard; Prolla, Tomas A
activity in the older muscle. ...
... Several studies have reported that  p53 
P53/MDM2 overexpression in metastatic endometrial cancer: correlation with clinicopathological features and patient outcome
P53/MDM2 overexpression in metastatic endometrial cancer: correlation with clinicopathological features and patient outcome
Jeczen, Ryszard; Skomra, Danuta; Cybulski, Marek; Schneider-Stock, Regine; Szewczuk, Wiktor; Roessner, Albert; Rechberger, Tomasz; Semczuk, Andrzej
/mdm2 distortions play a pivotal role in the ...
... dysfunction. In this study, as we determined  p53 
Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells
Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells
Tsuno, Takaya; Natsume, Atsushi; Katsumata, Shun; Mizuno, Masaaki; Fujita, Mitsugu; Osawa, Hirokatsu; Nakahara, Norimoto; Wakabayashi, Toshihiko; Satoh, Yu-ichiro; Inagaki, Masaki; Yoshida, Jun
gene mutation occurring in multinucleated giant ...
... tetramerization domain mutants of the human  p53 
Parallel analysis of tetramerization domain mutants of the human p53 protein using PCR colonies
Parallel analysis of tetramerization domain mutants of the human p53 protein using PCR colonies
Merritt, Joshua; Roberts, Kim G.; Butz, James A.; Edwards, Jeremy S.
transcription factor and tumor suppressor ...
... Background and aims  p53 
p53 protein accumulation as a prognostic marker in sporadic colorectal cancer
p53 protein accumulation as a prognostic marker in sporadic colorectal cancer
Lan, Yuan-Tzu; Chang, Shih-Ching; Fen-Yau Li, Anna; Lin, Tzu-Chen; Chen, Wei-Shone; Jiang, Jeng-Kai; Yang, Shung-Haur; Wang, Huann-Sheng; Lin, Jen-Kou
protein plays a crucial role in the pathogenesis ...
... in regulation of the tumor suppressor  p53 
Rad9 modulates the P21WAF1pathway by direct association with p53
Rad9 modulates the P21WAF1pathway by direct association with p53
Ishikawa, Kazuhiro; Ishii, Hideshi; Murakumo, Yoshiki; Mimori, Koshi; Kobayashi, Masahiko; Yamamoto, Ken-ichi; Mori, Masaki; Nishino, Hiroshi; Furukawa, Yusuke; Ichimura, Keiichi
-dependent transactivation of pro-survival P21 ...