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... Background  p53 
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Zhang, Lili; Nie, Linghu; Maki, Carl G
is a tumor suppressor and potent inhibitor of ...
... Background The tumor suppressor gene  p53 
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Baumbusch, Lars O; Myhre, Simen; Langerød, Anita; Bergamaschi, Anna; Geisler, Stephanie B; Lønning, Per E; Deppert, Wolfgang; Dornreiter, Irene; Børresen-Dale, Anne-Lise
(TP53) controls numerous signaling pathways and ...
... defects. Mutations in the tumor suppressor  p53 
Gene expression patterns associated with p53 status in breast cancer
Gene expression patterns associated with p53 status in breast cancer
Troester, Melissa A; Herschkowitz, Jason I; Oh, Daniel S; He, Xiaping; Hoadley, Katherine A; Barbier, Claire S; Perou, Charles M
occur more frequently in estrogen receptor (ER) ...
... viz. that between the tumour suppressor protein  p53 
Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53–HDM2 Protein–Protein Interaction
Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53–HDM2 Protein–Protein Interaction
Fischer, Peter M.
and its negative regulator HDM2, is reviewed ...
... The tumor suppressor  p53 
The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage
The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage
Masuda, Yoshiko; Futamura, Manabu; Kamino, Hiroki; Nakamura, Yasuyuki; Kitamura, Noriaki; Ohnishi, Shiho; Miyamoto, Yuji; Ichikawa, Hitoshi; Ohta, Tsutomu; Ohki, Misao; Kiyono, Tohru; Egami, Hiroshi; Baba, Hideo; Arakawa, Hirofumi
plays a crucial role in the cellular response to ...
... list of predicted targets. We applied HVDM to the  p53 
Ranked prediction of p53 targets using hidden variable dynamic modeling
Ranked prediction of p53 targets using hidden variable dynamic modeling
Barenco, Martino; Tomescu, Daniela; Brewer, Daniel; Callard, Robin; Stark, Jaroslav; Hubank, Michael
network, validating predictions experimentally ...
... elicited by viral oncogenes that abrogate the  p53 
Abstract
Abstract
and pRb tumor suppressors (Hanahan, 1985; Arbeit ...
... PUMA (  p53 
PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53
PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53
You, Xin; Boyle, David L; Hammaker, Deepa; Firestein, Gary S
-upregulated modulator of apoptosis) is a ...
... a recombinant adenovirus carrying human wild-type  p53 
Adenoviral-mediated transfer of human wild-type p53, GM-CSF and B7-1 genes results in growth suppression and autologous anti-tumor cytotoxicity of multiple myeloma cells in vitro
Adenoviral-mediated transfer of human wild-type p53, GM-CSF and B7-1 genes results in growth suppression and autologous anti-tumor cytotoxicity of multiple myeloma cells in vitro
Ren, Su-Ping; Wu, Chu-Tse; Huang, Wen-Rong; Lu, Zhuo-zhuang; Jia, Xiang-Xu; Wang, Lan; Lao, Miao-Fen; Wang, Li-Sheng
, granulocyte–macrophage colony-stimulating ...
... how MYC and PAX3-FKHR oncogenes influenced  p53 
Differential cooperation of oncogenes with p53 and Bax to induce apoptosis in rhabdomyosarcoma
Differential cooperation of oncogenes with p53 and Bax to induce apoptosis in rhabdomyosarcoma
Taylor, Alan C; Schuster, Katja; McKenzie, Pamela P; Harris, Linda C
-mediated apoptosis, rhabdomyosarcoma cells were ...
... factor in colorectal cancer. Moreover, an altered  p53 
Analysis of neuroendocrine differentiation and the p53/BAX pathway in UICC stage III colorectal carcinoma identifies patients with good prognosis
Analysis of neuroendocrine differentiation and the p53/BAX pathway in UICC stage III colorectal carcinoma identifies patients with good prognosis
Grabowski, Patricia; Sturm, Isrid; Schelwies, Katharina; Maaser, Kerstin; Buhr, Heinz-Johannes; Dörken, Bernd; Zeitz, Martin; Daniel, Peter T.; Scherübl, Hans
/BAX pathway is associated with a poor clinical ...
... reductase (FDXR) is a putative contributor to  p53 
Gene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin
Gene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin
Ichikawa, Wataru; Ooyama, Akio; Toda, Etsuko; Sugimoto, Yoshikazu; Oka, Toshinori; Takahashi, Takehiro; Shimizu, Michio; Sasaki, Yasutsuna; Hirayama, Renzo
-mediated apoptosis from 5-fluorouracil (5-FU) ...
... study was carried out to determine whether the  p53 
Contributions of differential p53 expression in the spontaneous immortalization of a chicken embryo fibroblast cell line
Contributions of differential p53 expression in the spontaneous immortalization of a chicken embryo fibroblast cell line
Christman, Shelly A; Kong, Byung-Whi; Landry, Megan M; Kim, Hyunggee; Foster, Douglas N
pathway played a role in the spontaneous ...
... an adenoviral vector coding a chimeric  p53 
Reversible inactivation of the transcriptional function of P53 protein by farnesylation
Reversible inactivation of the transcriptional function of P53 protein by farnesylation
Couderc, Bettina; Penary, Marie; Tohfe, Mustapha; Pradines, Anne; Casteignau, Antoine; Berg, Danièle; Favre, Gilles
protein by fusing ...
... Materials and methods The expression of HER2,  p53 
p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer
p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer
Yamashita, Hiroko; Toyama, Tatsuya; Nishio, Mariko; Ando, Yoshiaki; Hamaguchi, Maho; Zhang, Zhenhuan; Kobayashi, Shunzo; Fujii, Yoshitaka; Iwase, Hirotaka
, and Ki67 was examined by immunohistochemistry ...
... SH-SY5Y cells, effects of acrylamide on  p53 
Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide
Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide
Okuno, Takeo; Matsuoka, Masato; Sumizawa, Tomoyuki; Igisu, Hideki
protein and intracellular signal transducting ...
... factors. This was followed by an analysis of  p53 
Correlation analysis of two-dimensional gel electrophoretic protein patterns and biological variables
Correlation analysis of two-dimensional gel electrophoretic protein patterns and biological variables
Van Belle, Werner; Ånensen, Nina; Haaland, Ingvild; Bruserud, Øystein; Høgda, Kjell-Arild; Gjertsen, Bjørn Tore
2DE immunoblots from cancer cells, known to have ...
... also can interact with the tumor suppressor  p53 
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers
Paulsen, Michelle T; Starks, Adrienne M; Derheimer, Frederick A; Hanasoge, Sheela; Li, Liwu; Dixon, Jack E; Ljungman, Mats
both in vitro and in vivo and specifically ...
... were retrieved for the Blm, Sirt1, Parkin and  p53 
Generation of medaka gene knockout models by target-selected mutagenesis
Generation of medaka gene knockout models by target-selected mutagenesis
Taniguchi, Yoshihito; Takeda, Shunichi; Furutani-Seiki, Makoto; Kamei, Yasuhiro; Todo, Takeshi; Sasado, Takao; Deguchi, Tomonori; Kondoh, Hisato; Mudde, Josine; Yamazoe, Mitsuyoshi; Hidaka, Masayuki; Mitani, Hiroshi; Toyoda, Atsushi; Sakaki, Yoshiyuki; Plasterk, Ronald HA; Cuppen, Edwin
genes and functional characterization of ...
... Purpose: Given that  p53 
p53 Status does not affect photodynamic cell killing induced by hypericin
p53 Status does not affect photodynamic cell killing induced by hypericin
Lee, H. B.; Ho, A. S. H.; Teo, S. H.
is a tumor suppressor that plays a central role ...
... to examine the clinicopathologic features and  p53 
Colorectal Mucinous Adenocarcinoma: The Clinicopathologic Features and Significance of p16 and p53 Expression
Colorectal Mucinous Adenocarcinoma: The Clinicopathologic Features and Significance of p16 and p53 Expression
King-Yin Lam, Alfred; Ong, Kate; Ho, Yik-Hong
and p16 expressions in colorectal mucinous ...
... that thymidylate synthase (TS) expression,  p53 
Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer: implications for chemoresistance
Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer: implications for chemoresistance
Popat, Sanjay; Wort, Richard; Houlston, Richard S
and mismatch repair status have potential to ...
... investigate the overexpression of Bcl-2, Bax, or  p53 
Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T-cell lymphomas
Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T-cell lymphomas
Jung, Jin Tae; Kim, Dong Hwan; Kwak, Eun Kyung; Kim, Jong Gwang; Park, Tae In; Sohn, Sang Kyun; Do, Young Rok; Kwon, Ki Young; Song, Hong Suk; Park, Eui Hyun; Lee, Kyu Bo
with respect to the progression of PTCL. ...
... a systematic and comprehensive screening for  p53 
Saturation Screening for p53 Target Genes by Digital Fluorescent Differential Display
Saturation Screening for p53 Target Genes by Digital Fluorescent Differential Display
Cho, Yong-jig; Stein, Susanne; Jackson, Roger S.; Liang, Peng
tumor-suppressor gene targets. ...
... variety of data has revealed a critical role for  p53 
Tying the loose ends together in DNA double strand break repair with 53BP1
Tying the loose ends together in DNA double strand break repair with 53BP1
Adams, Melissa M; Carpenter, Phillip B
-binding protein 1 (53BP1) in the cellular ...