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... In this work we present evidence that the  p53 
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Dreyfus, David H; Nagasawa, Masayuki; Gelfand, Erwin W; Ghoda, Lucy Y
tumor suppressor protein and NF-κB transcription ...
... To further elucidate the significance of  p53 
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Feng, Yu-Zhen; Shiozawa, Tanri; Horiuchi, Akiko; Shih, Hsien-Chang; Miyamoto, Tsutomu; Kashima, Hiroyasu; Suzuki, Akihisa; Nikaido, Toshio; Konishi, Ikuo
mutation in endometrial carcinoma, we ...
... extended to three candidate HLA-DR–restricted  p53 
Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ1*0101– and HLA-DRβ1*0401–restricted epitope from p53
Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ1*0101– and HLA-DRβ1*0401–restricted epitope from p53
Rojas, José Manuel; McArdle, Stephanie E. B.; Horton, Roger B. V.; Bell, Matthew; Mian, Shahid; Li, Geng; Ali, Selman A.; Rees, Robert C.
peptides predicted by the evidence-based ...
... parameters of poor prognosis such as tumor grade,  p53 
Abstract
Abstract
expression and Ki67 proliferation index. ...
...  p53 
Establishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cells
Establishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cells
Chi, Tian-Yi; Chen, George G; Ho, Lok-Kee; Lai, Paul BS
is important in the development of hepatocellular ...
... Introduction A loss of  p53 
Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells
Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells
Rehman, Abdur; Chahal, Manpreet S; Tang, Xiaoting; Bruce, James E; Pommier, Yves; Daoud, Sayed S
function resulting from mutation is prevalent in ...
... Thymidylate synthase (TS) and tumor suppressor  p53 
Influence of thymidylate synthase and p53 protein expression on clinical outcome in patients with colorectal cancer
Influence of thymidylate synthase and p53 protein expression on clinical outcome in patients with colorectal cancer
Broll, R.; Busch, P.; Duchrow, M.; Oevermann, E.; Schwandner, O.; Farke, S.; Bruch, H. P.; Windhövel, U.
are two proteins with an influence on tumor ...
... signal in cells. There are two reported  p53 
Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation
Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation
Hanafusa, Tadashi; Shinji, Toshiyuki; Shiraha, Hidenori; Nouso, Kazuhiro; Iwasaki, Yoshiaki; Yumoto, Eichiro; Ono, Toshiro; Koide, Norio
regulatory regions in the IGFBP3 gene; one ...
... senescent fibroblasts markedly produced  p53 
Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts
Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts
Nishio, Koji; Inoue, Akira
molecules and anchored them to ...
... Purpose: Her-2/neu and  p53 
The efficacy of trastuzumab in Her-2/neu-overexpressing metastatic breast cancer is independent of p53 status
The efficacy of trastuzumab in Her-2/neu-overexpressing metastatic breast cancer is independent of p53 status
Köstler, Wolfgang J.; Brodowicz, Thomas; Hudelist, Gernot; Rudas, Margaretha; Horvat, Reinhard; Steger, Günther G.; Singer, Christian F.; Attems, Johannes; Rabitsch, Werner; Fakhrai, Negar; Elandt, Katarzyna; Wiltschke, Christoph; Hejna, Michael; Zielinski, Christoph C.
-mediated signalling have been shown to interact ...
... Background  p53 
Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus
Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus
Eberhart, Charles G; Chaudhry, Aneeka; Daniel, Richard W; Khaki, Leila; Shah, Keerti V; Gravitt, Patti E
mutations are relatively uncommon in ...
... system is discussed. Furthermore the role of  p53 
Immunologic aspect of ovarian cancer and p53 as tumor antigen
Immunologic aspect of ovarian cancer and p53 as tumor antigen
Nijman, HW; Lambeck, A; van der Burg, SH; van der Zee, AGJ; Daemen, T
as tumor antigen and its potential role as target ...
... relationship between the tumor suppressor gene  p53 
P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts
P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts
Chandar, Nalini; Saluja, Rasleen; Lamar, Peter C; Kolman, Kevin; Prozialeck, Walter C
and the nuclear signaling protein beta-catenin ...
... we describe the prognostic value of combined  p53 
Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: A tissue microarray study of 460 patients
Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: A tissue microarray study of 460 patients
Watson, Nicholas FS; Madjd, Zahra; Scrimegour, Duncan; Spendlove, Ian; Ellis, Ian O; Scholefield, John H; Durrant, Lindy G
/ Bcl-2 status in colorectal cancer. ...
... head and neck cancer (HNC), “overexpress”  p53 
Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites
Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites
Albers, Andreas E.; Ferris, Robert L.; Kim, Grace G.; Chikamatsu, Kazuaki; DeLeo, Albert B.; Whiteside, Theresa L.
. ...
... by reference to the creation of an array of  p53 
Fabrication of Protein Function Microarrays for Systems-Oriented Proteomic Analysis
Fabrication of Protein Function Microarrays for Systems-Oriented Proteomic Analysis
Blackburn, Jonathan M.; Hart, Darren J.
variants, and discuss methods for assay and data ...
... carcinomas. DKK1 translation can be induced by  p53 
Mutation analysis of DKK1 and in vivo evidence of predominant p53-independent DKK1 function in gliomas
Mutation analysis of DKK1 and in vivo evidence of predominant p53-independent DKK1 function in gliomas
Mueller, Wolf; Lass, Ulrike; Wellmann, Sven; Kunitz, Frank; Deimling, Andreas
, thereby linking TP53 and Wnt/β1-catenin ...
... A common sequence polymorphism at codon 72 of the  p53 
In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis
In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis
Sturm, Isrid; Bosanquet, Andrew G; Hummel, Michael; Dörken, Bernd; Daniel, Peter T
gene encoding either arginine or proline was ...
... the induction of apoptosis and the expression of  p53 
Increased expression of p53 and p21 (Waf1/Cip1) in the lesional skin of bleomycin-induced scleroderma
Increased expression of p53 and p21 (Waf1/Cip1) in the lesional skin of bleomycin-induced scleroderma
Yamamoto, Toshiyuki; Nishioka, Kiyoshi
, p21 (Waf1/Cip1), and proliferating cell nuclear ...
... to simultaneous activation of synthesis of VP and  p53 
Apoptotic signaling proteins: possible participation in the regulation of vasopressin and catecholamines biosynthesis in the hypothalamus
Apoptotic signaling proteins: possible participation in the regulation of vasopressin and catecholamines biosynthesis in the hypothalamus
Chernigovskaya, Elena V.; Taranukhin, Andrey G.; Glazova, Margarita V.; Yamova, Liubov A.; Fedorov, Lev M.
and Bcl-2 apoptotic proteins in the mouse brain. ...
... 72 (encoding either arginine or proline) of the  p53 
Detection of human papillomavirus DNA and p53 codon 72 polymorphism in prostate carcinomas of patients from Argentina
Detection of human papillomavirus DNA and p53 codon 72 polymorphism in prostate carcinomas of patients from Argentina
Leiros, Gustavo J; Galliano, Silvia R; Sember, Mario E; Kahn, Tomas; Schwarz, Elisabeth; Eiguchi, Kumiko
tumor-suppressor gene is discussed as a possible ...
... gene known as TP53 (encoding tumour protein  p53 
A Multiple-Pattern Biosequence Analysis Method for Diverse Source Association Mining
A Multiple-Pattern Biosequence Analysis Method for Diverse Source Association Mining
Chiu, David K. Y.; Lui, Thomas W. H.
) is analysed with the mutation records of ...
... cancer cell line, we investigated the role of  p53 
Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175
Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175
Hayward, R. L.; Schornagel, Q. C.; Tente, R.; Macpherson, J. S.; Aird, R. E.; Guichard, S.; Habtemariam, A.; Sadler, P.; Jodrell, D. I.
, p21/WAF1 and Bax in the cellular response to ...
... for the Rel-A subunit of NFκB and for  p53 
Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis
Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis
Elkon, Ran; Rashi-Elkeles, Sharon; Lerenthal, Yaniv; Linhart, Chaim; Tenne, Tamar; Amariglio, Ninette; Rechavi, Gideon; Shamir, Ron; Shiloh, Yosef
, two pivotal stress-induced transcription ...
... that disrupt the interaction between the  p53 
Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer
Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer
Espinoza-Fonseca, L Michel
tumor suppressor and its negative regulator MDM2 ...