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... as well as induction of apoptosis through  p53 
PTTG/securin activates expression of p53 and modulates its function
PTTG/securin activates expression of p53 and modulates its function
Hamid, Tariq; Kakar, Sham S
-dependent and ...
... Background and aims Overexpression of  p53 
Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy
Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy
Lechpammer, Mirna; Lukač, Josip; Lechpammer, Stanislav; Kovačević, Dujo; Loda, Massimo; Kusić, Zvonko
protein in malignancies induces an immune ...
... (LFS) patients with inherited mutations in  p53 
A novel genetic modifier of p53, mop1, results in embryonic lethality
A novel genetic modifier of p53, mop1, results in embryonic lethality
Evans, Susan C.; Liang, Min; Amos, Christopher; Gu, Xiangjun; Lozano, Guillermina
suggest risk modifiers at loci other than the ...
... we generated a series of Atm +/- mice on the  p53 
Atm heterozygous deficiency enhances development of mammary carcinomas in p53heterozygous knockout mice
Atm heterozygous deficiency enhances development of mammary carcinomas in p53heterozygous knockout mice
Umesako, Seiichi; Fujisawa, Kae; Iiga, Sayoko; Mori, Nobuko; Takahashi, Masahiro; Hong, Doo-Pyo; Song, Chang-Woo; Haga, Satomi; Imai, Syunsuke; Niwa, Otsura; Okumoto, Masaaki
+/- background with a certain predisposition to ...
... Introduction p14ARF stabilises nuclear  p53 
p14ARF expression in invasive breast cancers and ductal carcinoma in situ– relationships to p53 and Hdm2
p14ARF expression in invasive breast cancers and ductal carcinoma in situ– relationships to p53 and Hdm2
Vestey, SB; Sen, C; Calder, CJ; Perks, CM; Pignatelli, M; Winters, ZE
, with a variable expression of p14ARF mRNA in ...
... Previous reports have documented an attenuated  p53 
Induction of preneoplastic rat liver lesions with an attenuated p53 response by low doses of diethylnitrosamine
Induction of preneoplastic rat liver lesions with an attenuated p53 response by low doses of diethylnitrosamine
Silins, Ilona; Stenius, Ulla; Högberg, Johan
response to DNA-damage in preneoplastic ...
... treatment of hepatocellular carcinoma. Certain  p53 
Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line
Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line
Chan, Kin-Tak; Lung, Maria Li
mutants may enhance drug resistance in cancer ...
... factors in the human genome, and apply it to  p53 
Generation of p53 Target Database Via Integration of Microarray and Global p53 DNA-Binding Site Analysis
Generation of p53 Target Database Via Integration of Microarray and Global p53 DNA-Binding Site Analysis
Liu, Suxing; Mirza, Asra; Wang, Luquan
. ...
... core domain of the human tumor suppressor protein  p53 
CP-31398, a putative p53-stabilizing molecule tested in mammalian cells and in yeast for its effects on p53 transcriptional activity
CP-31398, a putative p53-stabilizing molecule tested in mammalian cells and in yeast for its effects on p53 transcriptional activity
Tanner, Stefan; Barberis, Alcide
in vitro. ...
... chromosome-17-centromere copy number, loss of the  p53 
A High Degree of Aneuploidy, Loss of p53 Gene, and Low Soluble p53 Protein Serum Levels Are Detected in Ulcerative Colitis Patients
A High Degree of Aneuploidy, Loss of p53 Gene, and Low Soluble p53 Protein Serum Levels Are Detected in Ulcerative Colitis Patients
Rosman-Urbach, Maya; Niv, Yaron; Birk, Yehudith; Smirnoff, Patricia; Zusman, Igor; Morgenstern, Sara; Schwartz, Betty
gene, and alterations in serum levels of the ...
... To identify additional targets of  p53 
Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses
Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses
Yoon, Kyong-Ah; Nakamura, Yusuke; Arakawa, Hirofumi
, we used a cDNA microarray system to examine ...
... of ARF is induced. ARF separates MDM2 from  p53 
G1 and S-Phase Checkpoints, Chromosome Instability, and Cancer
G1 and S-Phase Checkpoints, Chromosome Instability, and Cancer
Nojima, Hiroshi
by recruiting MDM2 into the nucleolus, possibly ...
... of the adenomatous polyposis coli (APC) and  p53 
Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells
Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells
Jaiswal, Aruna S.; Narayan, Satya
genes are commonly found in colorectal cancers. ...
... million deaths each year worldwide and protein  p53 
The role of circulating anti-p53 antibodies in patients with advanced non-small cell lung cancer and their correlation to clinical parameters and survival
The role of circulating anti-p53 antibodies in patients with advanced non-small cell lung cancer and their correlation to clinical parameters and survival
Bergqvist, Michael; Brattström, Daniel; Larsson, Anders; Hesselius, Patrik; Brodin, Ola; Wagenius, Gunnar
has been shown to be involved in the intricate ...
... When mammalian cells contain damaged DNA, the  p53 
Analyzing the G2/M Checkpoint
Analyzing the G2/M Checkpoint
Stark, George R.; Taylor, William R.
tumor suppressor and the Rb family of ...
... study was to find the correlation between serum  p53 
Serum p53 and bladder cancer: can serum p53 be used as a tumor marker?
Serum p53 and bladder cancer: can serum p53 be used as a tumor marker?
Malviya, Vibhav; Singh, Harbans; Dwivedi, U. S.; Usha,  ; Singh, P. B.
and carcinoma of the bladder and to investigate ...
... TCC [26, 27], (a rate similar to that of  p53 
Molecular pathways in bladder cancer
Molecular pathways in bladder cancer
Williams, Stephen G.; Stein, John P.
mutations), while no deletions were noted in ...
... of cell death pathways. In this regard, the  p53 
Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin
Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin
Ravizza, Raffaella; Gariboldi, Marzia B; Passarelli, Laura; Monti, Elena
protein has a well established role in the ...
... myotubes, expressed p19 ARF protein, and retained  p53 
Immortalization of mouse myogenic cells can occur without loss of p16INK4a, p19ARF, or p53 and is accelerated by inactivation of Bax
Immortalization of mouse myogenic cells can occur without loss of p16INK4a, p19ARF, or p53 and is accelerated by inactivation of Bax
Nowak, Jonathan A; Malowitz, Jonathan; Girgenrath, Mahasweta; Kostek, Christine A; Kravetz, Amanda J; Dominov, Janice A; Miller, Jeffrey Boone
functions. ...
... Peptides derived from over-expressed  p53 
Vaccination with p53-peptide–pulsed dendritic cells, of patients with advanced breast cancer: report from a phase I study
Vaccination with p53-peptide–pulsed dendritic cells, of patients with advanced breast cancer: report from a phase I study
Svane, Inge Marie; Pedersen, Anders E.; Johnsen, Hans E.; Nielsen, Dorte; Kamby, Claus; Gaarsdal, Eva; Nikolajsen, Kirsten; Buus, Søren; Claesson, Mogens H.
protein are presented by class I MHC molecules ...
... anoikis. Activation of the transcription factor  p53 
The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins
The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins
Cheema, Zulfiqar F; Santillano, Daniel R; Wade, Stephen B; Newman, Joseph M; Miranda, Rajesh C
was associated with induction of Fas expression, ...
... to provide independent prognostic information.  p53 
Prognostic Implications of hMLH1 and p53 Immunohistochemical Status in Right-Sided Colon Cancer
Prognostic Implications of hMLH1 and p53 Immunohistochemical Status in Right-Sided Colon Cancer
Smyth, Edward F.; Sharma, Abhiram; Sivarajasingham, Nala; Hartley, John; Monson, John R. T.; Cawkwell, Lynn
mutational status has been associated with both ...
... ER, HER-2/neu, Ki-67, cyclin A, cyclin D1, p21,  p53 
Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related
Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related
Bos, Reinhard; van Diest, Paul J; van der Groep, Petra; Shvarts, Avi; Greijer, Astrid E; van der Wall, Elsken
, and Bcl-2 was investigated by ...
... tumors were genetically characterized at the  p53 
Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma
Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma
Calogero, Antonella; Lombari, Vincenza; De Gregorio, Giorgia; Porcellini, Antonio; Ucci, Severine; Arcella, Antonietta; Caruso, Riccardo; Gagliardi, Franco Maria; Gulino, Alberto; Lanzetta, Gaetano; Frati, Luigi; Mercola, Dan; Ragona, Giuseppe
, MDM2 and INK4a/ARF loci, and fibronectin ...
... Abnormalities in the  p53 
p53tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis
p53tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis
Yamanishi, Yuji; Boyle, David L; Green, Douglas R; Keystone, Edward C; Connor, Alison; Zollman, Susan; Firestein, Gary S
tumor suppressor gene have been detected in ...