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... The human  p53 
Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?
Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?
Blackburn, Anneke C; Jerry, D Joseph
tumor suppressor gene TP53 is mutated at a high ...
...  p53 
The p53 pathway in breast cancer
The p53 pathway in breast cancer
Gasco, Milena; Shami, Shukri; Crook, Tim
mutation remains the most common genetic change ...
... Background The  p53 
Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest
Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest
Armit, Christopher J; O'Dea, Shirley; Clarke, Alan R; Harrison, David J
oncosuppressor protein is a critical mediator of ...
... growth factor (VEGF) and the tumor suppressor  p53 
Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features
Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features
Feng, Chang Wei; Wang, Li Dong; Jiao, Lian Hua; Liu, Bin; Zheng, Shu; Xie, Xin Ji
are fundamental play-markers of the angiogenic ...
... in some human cancer cell lines bearing mutant  p53 
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
Ohnishi, Takeo; Ohnishi, Ken; Takahashi, Akihisa
. ...
...  p53 
p53 Induction as an Indicator of DNA Damage
p53 Induction as an Indicator of DNA Damage
Selivanova, Galina
plays a central role in the cellular response to ...
... work demonstrating hormonal modulation of the  p53 
Hormonal control of p53 and chemoprevention
Hormonal control of p53 and chemoprevention
Jerry, D Joseph; Minter, Lisa M; Becker, Klaus A; Blackburn, Anneke C
tumor suppressor pathway draws together these ...
... February 2002. The 'guardian of the genome', the  p53 
Revealing the intricacies of cancer
Revealing the intricacies of cancer
Verhagen, Anne M; Lock, Peter
protein, a key regulator of cell cycle arrest and ...
... Based on the frequent inactivation of the  p53 
p53 Gene Therapy
p53 Gene Therapy
Schuler, Martin
gene product in human malignancy, and its ...
... is mainly attributed to its interaction with  p53 
The role of the ubiquitination-proteasome pathway in breast cancer: Use of mouse models for analyzing ubiquitination processes
The role of the ubiquitination-proteasome pathway in breast cancer: Use of mouse models for analyzing ubiquitination processes
Rossi, Sabrina; Loda, Massimo
, a transcription factor with known tumor ...
... The aim of this study was to investigate tissue  p53 
Prevalence of Serum p53 Antibodies against Tumor p53 Protein in Colorectal Cancer
Prevalence of Serum p53 Antibodies against Tumor p53 Protein in Colorectal Cancer
El-Awady, Saleh; Morshed, Mosaad; Khafagy, Wael; El-Maadawy, Gamal; El-Maadawy, Mohamed; El-Shobaky, Mohamed; Ragab, Elham
overexpression in paraffin embedded tumor and ...
... or -9 can activate a cascade of caspases. The  p53 
Apoptosis and Heart Failure
Apoptosis and Heart Failure
Chen, Qin M.; Tu, Victoria C.
protein is often required for damaging ...
... therapeutic effects of radiation by glycerol on  p53 
Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells
Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells
Ohnishi, Ken; Ota, Ichiro; Yane, Katsunari; Takahashi, Akihisa; Yuki, Kazue; Emoto, Mie; Hosoi, Hiroshi; Ohnishi, Takeo
-mutant anaplastic thyroid carcinoma cells (8305c ...
... Activating point mutations of the ras and  p53 
PNA Clamping Techniques for the Determination of Oncogene Mutations
PNA Clamping Techniques for the Determination of Oncogene Mutations
Schuermann, Marcus; Behn, Moira
type can be used as genetic markers to screen for ...
... are not well understood. To evaluate the role of  p53 
Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines
Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines
Lee, Terence; Lau, Tracy; Ng, Irene
and the cellular effects of DOX on hepatoma cell ...
... dysplasia and carcinoma. In the third column,  p53 
Preneoplastic lesions of the lung
Preneoplastic lesions of the lung
Greenberg, Alissa K; Yee, Herman; Rom, William N
is not observed in the normal bronchial mucosa or ...
... proliferates, more mutations accumulate, such as  p53 
Advanced Pancreatic Cancer
Advanced Pancreatic Cancer
Papadopoulos, Kyriakos P.; Sherman, William H.
, Smad4, or deleted in colon cancer gene (DCC). ...
... and altered morphology that requires intact  p53 
Complex roles for telomeres and telomerase in breast carcinogenesis
Complex roles for telomeres and telomerase in breast carcinogenesis
Artandi, Steven E
and Rb (retinoblastoma susceptibility gene ...
... (TNF) cytotoxicity by upregulating proapoptotic  p53 
Transforming growth factor-β1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts
Transforming growth factor-β1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts
Chang, Nan-Shan
and WW domain-containing oxidoreductase (WOX1). ...
... in tumor suppressors, and in particular the  p53 
All you need to know about p53
All you need to know about p53
Kopf, Eliezer
protein, this is a useful website; it includes a ...
... study was performed using antibodies against  p53 
Clinical and immunohistochemical study of eight cases with thymic carcinoma
Clinical and immunohistochemical study of eight cases with thymic carcinoma
Tomita, Masaki; Matsuzaki, Yasunori; Edagawa, Masao; Maeda, Masayuki; Shimizu, Tetsuya; Hara, Masaki; Onitsuka, Toshio
, bcl-2, Ki-67, carcinoembryonic antigen (CEA), ...
... kinase, and occurred even in the absence of  p53 
Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor
Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor
Wu, Ray-Chang; Blumenthal, Martina; Li, Xinwei; Schönthal, Axel H
, a tumor suppressor protein and recently ...
... Mutation of  p53 
Functional and Gene Expression Analysis of the p53 Signaling Pathway in Clear Cell Sarcoma of the Kidney and Congenital Mesoblastic Nephroma
Functional and Gene Expression Analysis of the p53 Signaling Pathway in Clear Cell Sarcoma of the Kidney and Congenital Mesoblastic Nephroma
Brownlee, Noel A.; Hazen-Martin, Debra J.; Garvin, A. Julian; Re, Gian G.
has been implicated in progression of classical ...
... ALA induced apoptosis, we examined its effect on  p53 
δ-Aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines
δ-Aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines
De Siervi, Adriana; Vazquez, Elba S; Rezaval, Carolina; Rossetti, María V; del Batlle, Alcira M
expression. ...
... mice have allowed formal tests of the roles that  p53 
Genetically Modified Mice in Cancer Research
Genetically Modified Mice in Cancer Research
Largaespada, David A.
gene-regulated pathways play during ...