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... Background The  p53 
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
Turenne, Gaetan A; Price, Brendan D
protein is activated by genotoxic stress, ...
... transcription mediated by tumor suppressor  p53 
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
Wang, Ying; Debatin, Klaus-Michael; Hug, Hubert
responsive promoter elements. ...
... No abstract available Definition Definition  p53 
p53 Protein, biological and clinical aspects
p53 Protein, biological and clinical aspects
Soussi, Thierry
is a 53 kD protein a that was discovered in 1979 ...
...  p53 
Biology of p53 and SV40 Large T Association
Biology of p53 and SV40 Large T Association
Montano, Ximena
was discovered because of its capacity to bind to ...
... of carcinogenesis. Altered expression of the  p53 
Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer
Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer
Graziano, Francesco; Cascinu, Stefano; Staccioli, Maria Pia; Catalano, Vincenzo; Rossi, Maria Cristina; Baldelli, Anna Maria; Giordani, Paolo; Muretto, Pietro; Catalano, Giuseppina
and the Deleted in Colon Cancer (DCC) proteins ...
... No abstract available Synonyms Synonyms TP53 (  p53 
TP53
TP53
Hainaut, Pierre
) is a ...
... studied tumor suppressor gene in solid tumors is  p53 
p53 Adenovirus as Gene Therapy for Ovarian Cancer
p53 Adenovirus as Gene Therapy for Ovarian Cancer
Carroll, Jennifer L.; Michael Mathis, J.; Bell, Maria C.; Santoso, Joseph T.
, a 53-kD nuclear phosphoprotein that binds DNA. ...
... No abstract available Definition Definition The  p53 
p53 Gene Family
p53 Gene Family
Kaelin, William
gene family currently consists of 3 genes: 1. ...
... damage-induced apoptotic pathway mediated by the  p53 
Gene Therapy Approaches to Sensitization of Human Prostate Carcinoma to Cisplatin by Adenoviral Expression of p53 and by Antisense Jun Kinase Oligonucleotide Methods
Gene Therapy Approaches to Sensitization of Human Prostate Carcinoma to Cisplatin by Adenoviral Expression of p53 and by Antisense Jun Kinase Oligonucleotide Methods
Gjerset, Ruth; Haghighi, Ali; Lebedeva, Svetlana; Mercola, Dan
tumor suppressor. ...
... gene (Rb), the tumor suppressor gene  p53 
The Molecular Genetics of Therapeutic Resistance in Malignant Astrocytomas
The Molecular Genetics of Therapeutic Resistance in Malignant Astrocytomas
Jennings, Mark T.; Iyengar, Sunita
, as well as those encoding the cyclins, their ...
... Abstract. Experimental data have shown  p53 
Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma
Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma
Volkmann, Martin; Schiff, Jan-H.; Hajjar, Yaser; Otto, Gerd; Stilgenbauer, Franziska; Fiehn, Walter; Galle, Peter R.; Hofmann, Walter J.
-dependent CD95 induction to be associated with ...
... prohibitin protein kinase RbK regulator of  p53 
Retinoblastoma Protein, biological and clinical functions
Retinoblastoma Protein, biological and clinical functions
Brown, Vivette; Gallie, Brenda
stability MDM2 replication licensing factor MCM7 ...
... Abstract Background:  p53 
Anchorage-Independent Growth of p53-Knockout Dermal Fibroblasts is Reversed by Wild-Type p53
Anchorage-Independent Growth of p53-Knockout Dermal Fibroblasts is Reversed by Wild-Type p53
Bush, Jason A.; Li, Gang
is a 393-residue nuclear phosphoprotein. ...
... In preclinical models adenovirus-mediated  p53 
Adenoviraler p53-Gentransfer (Adp53) und 5-FU-Chemotherapie wirken synergistisch in vitro und in vivo beim experimentellen Pankreaskarzinom
Adenoviraler p53-Gentransfer (Adp53) und 5-FU-Chemotherapie wirken synergistisch in vitro und in vivo beim experimentellen Pankreaskarzinom
Eisold, S.; Linnebacher, M.; Ryschich, E.; Schmidt, J.; Klar, E.; Herfarth, Ch.; Doeberitz, M. Knebel
gene transfer (Ad- ...
... and tumour suppressor gene alterations (mainly  p53 
Molecular Biology of Pancreatic Cancer
Molecular Biology of Pancreatic Cancer
Sakorafas, George H.; Tsiotos, Gregory G.
, pl6, DCC, etc.). ...
... Abstract. We evaluated  p53 
p53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue
p53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue
Broll, R.; Duchrow, M.; Oevermann, E.; Wellm, C.; Schwandner, O.; Schimmelpenning, H.; Roblick, U.J.; Bruch, H.P.; Windhövel, U.
autoantibodies ( ...
... Mutations of the  p53 
Multiplex PCR (MPCR) Screening Can Detect Small Intragenic p53 Deletion and Insertion Mutations
Multiplex PCR (MPCR) Screening Can Detect Small Intragenic p53 Deletion and Insertion Mutations
Runnebaum, Ingo B.; Wang-Gohrke, Shan
tumor suppressor gene are the most common ...
... suppressor genes. HIC-1 contains a consensus  p53 
The Molecular Pathogenesis of Ovarian Cancer
The Molecular Pathogenesis of Ovarian Cancer
Hilary Russell, S. E.
binding site and, therefore, is a potential ...
... Background: The tumor suppressor protein  p53 
p53 Levels, Cell Cycle Kinetics and Radiosensitivity in Two SV40 Transformed Wi38VA13 Fibroblast Strains
p53 Levels, Cell Cycle Kinetics and Radiosensitivity in Two SV40 Transformed Wi38VA13 Fibroblast Strains
Werner, Frank; Zölzer, Friedo; Streffer, Christian
which can mediate an ionizing radiation-induced ...
... same X chromosome, and identical mutations in the  p53 
Alterations in Oncogenes, Tumor Suppressor Genes, and Growth Factors Associated with Epithelial Ovarian Cancers
Alterations in Oncogenes, Tumor Suppressor Genes, and Growth Factors Associated with Epithelial Ovarian Cancers
Bast, Robert C., Jr.; Mills, Gordon B.
gene in primary and secondary tumors. ...
... cancer. A number of studies have revealed that  p53 
Presence of Serum p53 Antibodies is Associated with Decreased In Vitro Chemosensitivity in Patients with Esophageal Cancer
Presence of Serum p53 Antibodies is Associated with Decreased In Vitro Chemosensitivity in Patients with Esophageal Cancer
Shimada, Hideaki; Okazumi, Shinichi; Takeda, Akihiko; Nabeya, Yoshihiro; Matsubara, Hisahiro; Funami, Yutaka; Hayashi, Hideki; Gunji, Yoshio; Suzuki, Takao; Ochiai, Takenori
genetic alteration and protein overexpression can ...
...    p53 
Characterization of CD8+ cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant
Characterization of CD8+ cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant
Hilburger Ryan, Mary; Abrams, Scott I.
mutations are frequently found in human cancers ...
... Mutations of the  p53 
p53 mutations are rare events in recurrent cervical cancer
p53 mutations are rare events in recurrent cervical cancer
Denk, Claudia; Butz, Karin; Schneider, Achim; Dürst, Matthias; Hoppe-Seyler, Felix
gene have been shown to be associated with ...
... The main reason for the recent interest in  p53 
The timing and characterization of p53 mutations in progression from atypical ductal hyperplasia to invasive lesions in the breast cancer
The timing and characterization of p53 mutations in progression from atypical ductal hyperplasia to invasive lesions in the breast cancer
Kang, Joo; Kim, Sun; Noh, Dong-Young; Choe, Kuk; Lee, Eun; Kang, Han-Sung
is that almost 50% of human cancers contain ...
... set up to identify single point mutations in the  p53 
SSCP Analysis of Point Mutations by Multicolor Capillary Electrophoresis
SSCP Analysis of Point Mutations by Multicolor Capillary Electrophoresis
Hayashi, Kenshi; Wenz, H. Michael; Inazuka, Masakazu; Tahira, Tomoko; Sasaki, Tomonari; Atha, Donald H.
gene. ...