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... The tumor suppressor gene TP53, encoding the  p53 
Analysis of the p53 Status of Tumors
Analysis of the p53 Status of Tumors
Bergh, Jonas
protein, has its gene locus on the short arm of ...
...  p53 
Activation of p53 Protein Function in Response to Cellular Irradiation
Activation of p53 Protein Function in Response to Cellular Irradiation
Blaydes, Jeremy P.; Sparks, Alison; Hupp, Ted R.
protein is a key regulatory component of a ...
... is dependent on the tumor suppressor protein  p53 
Induction of p53 Protein as a Marker for Ionizing Radiation Exposure In Vivo
Induction of p53 Protein as a Marker for Ionizing Radiation Exposure In Vivo
MacCallum, David E.; Hupp, Ted R.
(3), prompted further examination of the response ...
... tumours in the thymus. Specifically, the roles of  p53 
Role of the mitotic checkpoint in transformation of Brca2 null cells
Role of the mitotic checkpoint in transformation of Brca2 null cells
Davies, Michael
or related molecules and the spindle assembly ...
... of defective, dominant negative alleles of  p53 
Killing the umpire: cooperative defects in mitotic checkpoint and BRCA2 genes on the road to transformation
Killing the umpire: cooperative defects in mitotic checkpoint and BRCA2 genes on the road to transformation
McKeon, Frank
and of the mitotic checkpoint gene Bub1, both of ...
... increased frequency of TP53 mutations, frequent  p53 
The pathology of familial breast cancer: Immunohistochemistry and molecular analysis
The pathology of familial breast cancer: Immunohistochemistry and molecular analysis
Osin, Pinchas P; Lakhani, Sunil R
protein stabilization and absence of ...
... Abstract. The  p53 
Functions of the MDM2 oncoprotein
Functions of the MDM2 oncoprotein
Freedman, D. A.; Wu, L.; Levine, A. J.
protein is activated in response to physiological ...
... is unknown. In a recent study accumulation of  p53 
Immunocytochemical Accumulation of p53 in Corticotroph Adenomas: Relationship with Heat Shock Proteins and Apoptosis
Immunocytochemical Accumulation of p53 in Corticotroph Adenomas: Relationship with Heat Shock Proteins and Apoptosis
Kontogeorgos, George; Kapranos, Nikiforos; Thodou, Eleni; Sambaziotis, Demetrios; Tsagarakis, Stylianos
protein was detected by immunohistochemistry in a ...
... using monoclonal antibody DO-7 to assess  p53 
Sun-exposure- and aging-dependent p53 protein accumulation results in growth advantage for tumour cells in carcinogenesis of nonmelanocytic skin cancer
Sun-exposure- and aging-dependent p53 protein accumulation results in growth advantage for tumour cells in carcinogenesis of nonmelanocytic skin cancer
Liang, Sheng-Ben; Ohtsuki, Y.; Furihata, Mutsuo; Takeuchi, Tamotsu; Iwata, J.; Chen, Bing-Kun; Sonobe, Hiroshi
protein accumulation related to sun exposure and ...
... contributed to our understanding of the role of  p53 
The role of p53 in tumour suppression: lessons from mouse models
The role of p53 in tumour suppression: lessons from mouse models
Attardi, L. D.; Jacks, T.
in tumour suppression. ...
... Several mutations prevent the expression of  p53 
Contributions of p53 and PMA to g-irradiation induced apoptosis in Jurkat cells
Contributions of p53 and PMA to g-irradiation induced apoptosis in Jurkat cells
Vigorito, E.; Plaza, S.; Mir, L.; Mongay, L.; Viñas, O.; Serra-Pagès, C.; Vives, J.
in the human lymphoblastoid T cell line Jurkat. ...
... with pancreaticobiliary maljunction, we examined  p53 
p53 Gene mutations and overexpression of p53 product in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction
p53 Gene mutations and overexpression of p53 product in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction
Matsubara, Toshiki; Funabiki, Takahiko; Jinno, Osamu; Sakurai, Yoichi; Hasegawa, Shigeru; Imazu, Hiroki; Ochiai, Masahiro
gene mutations, loss of heterozygosity of ...
... In most laryngeal cancers, the function of  p53 
Growth inhibition of human laryngeal cancer cell with the adenovirus-mediated p53 gene
Growth inhibition of human laryngeal cancer cell with the adenovirus-mediated p53 gene
Qi, Wang; Zu-ze, Wu; De-min, Han; Wei, Zhang; Wen-ge, Wang
gene is down regulated. ...
... the quantified overexpression of the oncoproteins  p53 
Use of Possible Synergistic Expression of p53 and p185 as a Prognostic Tool for Stage I Non-small-cell Lung Cancer
Use of Possible Synergistic Expression of p53 and p185 as a Prognostic Tool for Stage I Non-small-cell Lung Cancer
Cantero, Ramón; Torres, Antonio J.; Maestro, Marisa; Fernández, Cristina; Hernando, Florentino; del Barco, Victoria; Sanz, Teresa; Balibrea, Jose L.
and p185 was evaluated. ...
... Abstract. The tumour suppressor  p53 
The dual role model for p53 in maintaining genomic integrity
The dual role model for p53 in maintaining genomic integrity
Janus, F.; Albrechtsen, N.; Dornreiter, I.; Wiesmüller, L.; Grosse, F.; Deppert, W.
is a potent mediator of cellular responses ...
... cancer. Of late, the clinical significance of  p53 
Lymph node metastasis and p53 overexpression in combination for the prognosis for the colorectal cancer
Lymph node metastasis and p53 overexpression in combination for the prognosis for the colorectal cancer
Yamamura, T.; Matsuzaki, H.; Suda, T.; Ozasa, T.; Matsuoka, H.; Ikai, H.; Oikawa, H.; Akaish, O.; Tsukikawa, S.; Yamaguchi, S.
as a prognostic factor has been reported. ...
... Overexpression of the normal  p53 
Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line
Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line
Maxwell, S. A.; Acosta, S. A.; Davis, G. E.
protein in tumor cell lines is known to induce ...
... Abstract  Alterations to  p53 
Prognostic significance of p53 gene mutations and p53 protein expression in synovial sarcomas
Prognostic significance of p53 gene mutations and p53 protein expression in synovial sarcomas
Schneider-Stock, R.; Onnasch, D.; Haeckel, C.; Mellin, W.; Franke, D.-S.; Roessner, A.
seem to be of prognostic significance in soft ...
... rates. We investigated whether alterations in  p53 
P53 Overexpression and Proliferative Potential in Malignant Meningiomas
P53 Overexpression and Proliferative Potential in Malignant Meningiomas
Nagashima, G.; Aoyagi, M.; Yamamoto, M.; Yamamoto, S.; Wakimoto, H.; Ohno, K.; Yamamoto, K.; Hirakawa, K.
protein may contribute to malignant progression ...
... Purpose: Adenovirus-mediated  p53 
Adenovirus-mediated p53 gene therapy has greater efficacy when combined with chemotherapy against human head and neck, ovarian, prostate, and breast cancer
Adenovirus-mediated p53 gene therapy has greater efficacy when combined with chemotherapy against human head and neck, ovarian, prostate, and breast cancer
Gurnani, Maya; Lipari, Philip; Dell, Janet; Shi, Bin; Nielsen, Loretta L.
gene therapy for cancer is currently undergoing ...
... and clonogenic survival in cells with different  p53 
Radiation induced chromosome aberrations and clonogenic survival in human lymphoblastoid cell lines with different p53 status
Radiation induced chromosome aberrations and clonogenic survival in human lymphoblastoid cell lines with different p53 status
Geiger, Constanze; Weber, Klaus J.; Wenz, Frederik
status. ...
... strongly indicate that the determination of  p53 
The need for microdissectional tumor cell preparation during the molecular genetic analysis of prostate cancer
The need for microdissectional tumor cell preparation during the molecular genetic analysis of prostate cancer
Kuczyk, Markus; Serth, Jürgen; Bokemeyer, Carsten; Machtens, Stefan; Schwede, Jörn; Herrmann, Roland; Paeslack, Ute; Truss, Michael C.; Knüchel, Ruth; Jonas, Udo
inactivation allows the identification of a ...
... The  p53 
The biological response of MCF7 breast cancer cells to proteosome inhibition or γ-radiation is unrelated to the level of p53 induction
The biological response of MCF7 breast cancer cells to proteosome inhibition or γ-radiation is unrelated to the level of p53 induction
Fallis, L. H.; Richards, E.; O'Connor, D. J.; Zhong, S.; Hsieh, J. K.; Packham, G.; Lu, X.
tumour suppressor is stabilised following ...
... The  p53 
Protein kinase CK2-dependent regulation of p53 function: Evidence that the phosphorylation status of the serine 386 (CK2) site of p53 is constitutive and stable
Protein kinase CK2-dependent regulation of p53 function: Evidence that the phosphorylation status of the serine 386 (CK2) site of p53 is constitutive and stable
McKendrick, Linda; Milne, Diane; Meek, David
tumour suppressor protein is regulated by several ...
... pretreatment expression of the tumour-suppressor  p53 
bcl-2 immunoreactivity but not p53 accumulation associated with tumour response to radiotherapy in cervical carcinoma
bcl-2 immunoreactivity but not p53 accumulation associated with tumour response to radiotherapy in cervical carcinoma
Radhakrishana Pillai, M.; Jayaprakash, P. G.; Krishnan Nair, M.
protein and the anti-apoptotic protein bcl-2 and ...