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... (LFS) patients with inherited mutations in  p53 
A novel genetic modifier of p53, mop1, results in embryonic lethality
A novel genetic modifier of p53, mop1, results in embryonic lethality
Evans, Susan C.; Liang, Min; Amos, Christopher; Gu, Xiangjun; Lozano, Guillermina
suggest risk modifiers at loci other than the ...
... of the human tumor suppressor protein  P53 
Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast
Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast
Kamoun, Yosra; Mabrouk, Imed; Delahodde, Agnes; Boukid, Fatma; Yacoubi-Hadj Amor, Ines; Mokdad-Gargouri, Raja; Gargouri, Ali
causes cell death of the yeast Saccharomyces ...
... Here, we examine the impact of ERβ on the ERα-  p53 
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer
Lu, Wenwen; Katzenellenbogen, Benita S.
loop in breast cancer. ...
... amplified in transformed murine cells. It is a  p53 
MDM2
MDM2
Meek, David W.
-binding nuclear protein that antagonizes and ...
... Recent work has shown that the basal level of  p53 
p53 regulates LIF expression in human medulloblastoma cells
p53 regulates LIF expression in human medulloblastoma cells
Baxter, Euan W.; Milner, Jo
plays an important role in maternal reproduction ...
... cells. HCT 116 colorectal cancer cells expressing  p53 
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Beaino, Wissam; Guo, Yunjun; Chang, Albert J.; Anderson, Carolyn J.
(+/+) and not expressing ...
... To further elucidate the significance of  p53 
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Feng, Yu-Zhen; Shiozawa, Tanri; Horiuchi, Akiko; Shih, Hsien-Chang; Miyamoto, Tsutomu; Kashima, Hiroyasu; Suzuki, Akihisa; Nikaido, Toshio; Konishi, Ikuo
mutation in endometrial carcinoma, we ...
... organelles responsible for vital cell functions.  p53 
p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases
p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases
Dai, Chun-Qiu; Luo, Ting-Ting; Luo, Shi-Cheng; Wang, Jia-Qi; Wang, Sheng-Ming; Bai, Yun-Hu; Yang, Yan-Ling; Wang, Ya-Yun
is a transcription factor that regulates the DNA ...
... The  p53 
Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics
Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics
Wang, Shaomeng; Zhao, Yujun; Bernard, Denzil; Aguilar, Angelo; Kumar, Sanjeev
tumor suppressor protein is a transcriptional ...
... miRNAs in colon cancer cell lines HCT116  p53 
Dynamic analysis of DNA damage induced miRNAs in colon cancer cells
Dynamic analysis of DNA damage induced miRNAs in colon cancer cells
Zhang, Weimin; Yang, Fang; Zhan, Qimin
+/+ and HCT116 ...
...  p53 
Isolation of p53 Inhibitors by Screening Chemical Libraries in Cell-Based Readout System
Isolation of p53 Inhibitors by Screening Chemical Libraries in Cell-Based Readout System
Gudkov, Andrei; Komarova, Elena
is a key mediator of cell response to a variety ...
... and activate the transcription factor  p53 
Role of the nucleus in apoptosis: signaling and execution
Role of the nucleus in apoptosis: signaling and execution
Prokhorova, Evgeniia A.; Zamaraev, Alexey V.; Kopeina, Gelina S.; Zhivotovsky, Boris; Lavrik, Inna N.
either directly or by means of prior activation ...
... Lymphomas frequently retain wild-type (wt)  p53 
HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas
HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas
Sosin, Angela M; Burger, Angelika M; Siddiqi, Aisha; Abrams, Judith; Mohammad, Ramzi M; Al-Katib, Ayad M
function but overexpress HDM2, thereby ...
... Wild-type sequence (wt)  p53 
CD4+ T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head and neck cancer
CD4+ T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head and neck cancer
Chikamatsu, Kazuaki; Sakakura, Koichi; Takahashi, Goro; Okamoto, Atsushi; Furuya, Nobuhiko; Whiteside, Theresa L.; DeLeo, Albert B.; Masuyama, Keisuke
peptides are attractive candidates for broadly ...
... Background The tumor suppressor  p53 
Modeling the role of p53 pulses in DNA damage- induced cell death decision
Modeling the role of p53 pulses in DNA damage- induced cell death decision
Sun, Tingzhe; Chen, Chun; Wu, Yuanyuan; Zhang, Shuai; Cui, Jun; Shen, Pingping
plays pivotal roles in tumorigenesis ...
... ligament cells via a pathway that requires  p53 
Anoikis triggers Mdm2-dependent p53 degradation
Anoikis triggers Mdm2-dependent p53 degradation
Ghosh, Abhijit; Chen, Tina Chunyuan; Kapila, Yvonne L.
transcriptional downregulation. ...
... of abnormal cells. The tumor suppressor protein,  p53 
The DNA Damage Response Mediates Apoptosis and Tumor Suppression
The DNA Damage Response Mediates Apoptosis and Tumor Suppression
Baran, Katherine; Rodriguez, Diego; Green, Douglas
, is one of the most essential molecules keeping ...
... Background In HPV infected cells  p53 
Human papillomavirus 18 E6 inhibits phosphorylation of p53 expressed in HeLa cells
Human papillomavirus 18 E6 inhibits phosphorylation of p53 expressed in HeLa cells
Ajay, Amrendra K; Meena, Avtar S; Bhat, Manoj K
function is abrogated by E6 and even ectopically ...
... Background The  p53 
Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway
Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway
Zhang, Ping; Kratz, Anne Sophie; Salama, Mohammed; Elabd, Seham; Heinrich, Thorsten; Wittbrodt, Joachim; Blattner, Christine; Davidson, Gary
tumor suppressor protein is mainly regulated by ...
... extended to three candidate HLA-DR–restricted  p53 
Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ1*0101– and HLA-DRβ1*0401–restricted epitope from p53
Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ1*0101– and HLA-DRβ1*0401–restricted epitope from p53
Rojas, José Manuel; McArdle, Stephanie E. B.; Horton, Roger B. V.; Bell, Matthew; Mian, Shahid; Li, Geng; Ali, Selman A.; Rees, Robert C.
peptides predicted by the evidence-based ...
... Background Accumulated evidence suggests that  p53 
Potential Increase in the Prognostic Value of p53 Mutation by Pro72 Allele in Stage I Non-Small-Cell Lung Cancer
Potential Increase in the Prognostic Value of p53 Mutation by Pro72 Allele in Stage I Non-Small-Cell Lung Cancer
Chien, Wen-Pin; Wong, Ruey-Hong; Wu, Tsu-Chin; Cheng, Ya-Wen; Chen, Chih-Yi; Lee, Huei
function altered by its gene mutation or genetic ...
... are detailing with increasing precision the  p53 
Whole-genome cartography of p53 response elements ranked on transactivation potential
Whole-genome cartography of p53 response elements ranked on transactivation potential
Tebaldi, Toma; Zaccara, Sara; Alessandrini, Federica; Bisio, Alessandra; Ciribilli, Yari; Inga, Alberto
-directed gene regulatory network that, ...
...  p53 
In Vivo Footprinting and DNA Affinity Chromatography for Analysis of p53 DNA Binding Ability
In Vivo Footprinting and DNA Affinity Chromatography for Analysis of p53 DNA Binding Ability
Molina, Maria Patricia; Cain, Christine; Bargonetti, Jill
is a sequence-specific DNA binding protein. ...
... Mutational inactivation of the tumour suppressor  p53 
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
Kang, Khong Bee; Zhu, Congju; Yong, Sook Kwin; Gao, Qiuhan; Wong, Meng Cheong
gene is frequent in malignant gliomas. ...
... It is ironic that the  p53 
Tumor Suppressor p53: A Multifunctional Protein Implicated in Seizure-Induced Neuronal Cell Death
Tumor Suppressor p53: A Multifunctional Protein Implicated in Seizure-Induced Neuronal Cell Death
Tan, Zhiqun; Schreiber, Steven S.
“tumor antigen”, first discovered more than 20 ...

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