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... Background The tumor suppressor protein  p53 
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
Loewer, Alexander; Karanam, Ketki; Mock, Caroline; Lahav, Galit
is activated by cellular stress. ...
... The  p53 
p53: Guardian of the Metabolome
p53: Guardian of the Metabolome
Poyurovsky, Masha V.; Prives, Carol
tumor suppressor protein is critically important ...
... The well-known transcription factor  p53 
Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury
Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury
Kim, Young-Ae; Kim, Mi-Young; Yu, Hye Yon; Mishra, Siddhartha Kumar; Lee, Jae-Hyeok; Choi, Kyeong Sook; Kim, Jae-Ho; Xiang, Yang Kevin; Jung, Yi-Sook
is known to cause apoptosis in cardiomyocytes ...
... poorly known. We identify the presence of three  p53 
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Kelkar, Madhura G.; Thakur, Bhushan; Derle, Abhishek; Chatterjee, Sushmita; Ray, Pritha; De, Abhijit
binding sites on the human NIS promoter sequence ...
... As a critical tumor suppressor,  p53 
Functional analysis of the acetylation of human p53 in DNA damage responses
Functional analysis of the acetylation of human p53 in DNA damage responses
Chung, Sun-Ku; Zhu, Shengyun; Xu, Yang; Fu, Xuemei
is inactivated in human cancer cells by somatic ...
...  p53 
Noncoding RNAs Regulating p53 and c-Myc Signaling
Noncoding RNAs Regulating p53 and c-Myc Signaling
Mei, Yide; Wu, Mian
is one of the most important tumor suppressors ...
... Background The  p53 
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
Turenne, Gaetan A; Price, Brendan D
protein is activated by genotoxic stress, ...
...  p53 
Targeting p53 for enhanced radio- and chemo-sensitivity
Targeting p53 for enhanced radio- and chemo-sensitivity
Lu, Chao; El-Deiry, Wafik S.
acts as a central mediator of the cellular ...
... Background The  p53 
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Wachter, Franziska; Grunert, Michaela; Blaj, Cristina; Weinstock, David M; Jeremias, Irmela; Ehrhardt, Harald
protein is the best studied target in human ...
...  p53 
Mechanisms of Mutant p53 Stabilization in Cancer
Mechanisms of Mutant p53 Stabilization in Cancer
Frum, Rebecca A.; Grossman, Steven R.
transactivates cell cycle inhibitory, apoptosis ...
... expression, carry a missense mutation at the  p53 
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Gottschalk, Benjamin; Klein, Andreas
codon 242 (mouse G242 corresponds to human hot ...
... The tumor suppressor  p53 
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif
Worrall, Erin G.; Wawrzynow, Bartosz; Worrall, Liam; Walkinshaw, Malcolm; Ball, Kathryn L.; Hupp, Ted R.
has evolved a MDM2-dependent feedback loop that ...
... is the multifunctional transcription factor  p53 
p53 Replacement Therapy for Cancer
p53 Replacement Therapy for Cancer
Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi
gene that regulates diverse cellular phenomena ...
... smoking, alcohol, and human papillomavirus (HPV).  p53 
p53 in Head and Neck Squamous Cell Carcinoma
p53 in Head and Neck Squamous Cell Carcinoma
Philips, Ramez; Pan, Quintin
, a transcriptional factor, is the most commonly ...
... No abstract available 1 The  p53 
p53 Inhibitors as Cancer Sensitizing Agents
p53 Inhibitors as Cancer Sensitizing Agents
Maina, Flavio; Dono, Rosanna
Player: A Stage Director for the Fate of Stressed ...
...  p53 
Regulation of tumor suppressor p53 at the RNA level
Regulation of tumor suppressor p53 at the RNA level
Vilborg, Anna; Wilhelm, Margareta T.; Wiman, Klas G.
is a key tumor suppressor that triggers cell ...
... Background The tumour suppressor protein  p53 
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
Bereczki, Orsolya; Ujfaludi, Zsuzsanna; Pardi, Norbert; Nagy, Zita; Tora, Laszlo; Boros, Imre M; Balint, Eva
is a sequence specific DNA-binding transcription ...
... Background The  p53 
Regression based predictor for p53 transactivation
Regression based predictor for p53 transactivation
Gowrisankar, Sivakumar; Jegga, Anil G
protein is a master regulator that controls the ...
... The tumor suppressor  p53 
PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway
PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway
Xu, Lanjun; Hu, Jing; Zhao, Yuanbo; Hu, Jia; Xiao, Juan; Wang, Yanming; Ma, Dalong; Chen, Yingyu
is at the hub of cellular signaling networks that ...
... neurons of the substantia nigra pars compacta.  p53 
Direct α-synuclein promoter transactivation by the tumor suppressor p53
Direct α-synuclein promoter transactivation by the tumor suppressor p53
Duplan, Eric; Giordano, Cécile; Checler, Frédéric; Alves da Costa, Cristine
is a major neuronal pro-apoptotic factor that is ...
... One of the key regulators of the DDR is  p53 
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
Valentine, Jane M; Kumar, Sonia; Moumen, Abdeladim
, itself tightly regulated by MDM2. ...
... Tumor suppressor  p53 
Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
Kim, Young June; Kim, Tae-Hyun; Kim, Minjeong; Kim, Min Ju; Kim, Hae-Won; Shim, Hosup
plays a critical role in the regulation of cell ...
... not fully understood. The presence of wild type  p53 
Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation
Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation
Bragado, Paloma; Armesilla, Alejandro; Silva, Augusto; Porras, Almudena
has been suggested to be important for cisplatin ...
... (CD71, CARM1, PI3KCA&TK1), P-cadherin,  p53 
ESP Abstracts 2012
ESP Abstracts 2012
and with lower levels of ER expression and ...
... we explore the modifications and activation of  p53 
Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin
Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin
Illuzzi, Jennifer L.; Vickers, Cassie A.; Kmiec, Eric B.
and keystone regulators of the cell stress ...

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