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... Background The  p53 
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
Turenne, Gaetan A; Price, Brendan D
protein is activated by genotoxic stress, ...
...  p53 
Targeting p53 for enhanced radio- and chemo-sensitivity
Targeting p53 for enhanced radio- and chemo-sensitivity
Lu, Chao; El-Deiry, Wafik S.
acts as a central mediator of the cellular ...
... Background The  p53 
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
Wachter, Franziska; Grunert, Michaela; Blaj, Cristina; Weinstock, David M; Jeremias, Irmela; Ehrhardt, Harald
protein is the best studied target in human ...
...  p53 
Mechanisms of Mutant p53 Stabilization in Cancer
Mechanisms of Mutant p53 Stabilization in Cancer
Frum, Rebecca A.; Grossman, Steven R.
transactivates cell cycle inhibitory, apoptosis ...
... expression, carry a missense mutation at the  p53 
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype
Gottschalk, Benjamin; Klein, Andreas
codon 242 (mouse G242 corresponds to human hot ...
... The tumor suppressor  p53 
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif
Worrall, Erin G.; Wawrzynow, Bartosz; Worrall, Liam; Walkinshaw, Malcolm; Ball, Kathryn L.; Hupp, Ted R.
has evolved a MDM2-dependent feedback loop that ...
... is the multifunctional transcription factor  p53 
p53 Replacement Therapy for Cancer
p53 Replacement Therapy for Cancer
Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi
gene that regulates diverse cellular phenomena ...
... No abstract available 1 The  p53 
p53 Inhibitors as Cancer Sensitizing Agents
p53 Inhibitors as Cancer Sensitizing Agents
Maina, Flavio; Dono, Rosanna
Player: A Stage Director for the Fate of Stressed ...
... Background and aims Overexpression of  p53 
Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy
Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy
Lechpammer, Mirna; Lukač, Josip; Lechpammer, Stanislav; Kovačević, Dujo; Loda, Massimo; Kusić, Zvonko
protein in malignancies induces an immune ...
...  p53 
Regulation of tumor suppressor p53 at the RNA level
Regulation of tumor suppressor p53 at the RNA level
Vilborg, Anna; Wilhelm, Margareta T.; Wiman, Klas G.
is a key tumor suppressor that triggers cell ...
... Background The tumour suppressor protein  p53 
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
Bereczki, Orsolya; Ujfaludi, Zsuzsanna; Pardi, Norbert; Nagy, Zita; Tora, Laszlo; Boros, Imre M; Balint, Eva
is a sequence specific DNA-binding transcription ...
... Background The  p53 
Regression based predictor for p53 transactivation
Regression based predictor for p53 transactivation
Gowrisankar, Sivakumar; Jegga, Anil G
protein is a master regulator that controls the ...
... The tumor suppressor  p53 
PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway
PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway
Xu, Lanjun; Hu, Jing; Zhao, Yuanbo; Hu, Jia; Xiao, Juan; Wang, Yanming; Ma, Dalong; Chen, Yingyu
is at the hub of cellular signaling networks that ...
... neurons of the substantia nigra pars compacta.  p53 
Direct α-synuclein promoter transactivation by the tumor suppressor p53
Direct α-synuclein promoter transactivation by the tumor suppressor p53
Duplan, Eric; Giordano, Cécile; Checler, Frédéric; Alves da Costa, Cristine
is a major neuronal pro-apoptotic factor that is ...
... One of the key regulators of the DDR is  p53 
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
Valentine, Jane M; Kumar, Sonia; Moumen, Abdeladim
, itself tightly regulated by MDM2. ...
... Tumor suppressor  p53 
Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
Kim, Young June; Kim, Tae-Hyun; Kim, Minjeong; Kim, Min Ju; Kim, Hae-Won; Shim, Hosup
plays a critical role in the regulation of cell ...
... not fully understood. The presence of wild type  p53 
Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation
Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation
Bragado, Paloma; Armesilla, Alejandro; Silva, Augusto; Porras, Almudena
has been suggested to be important for cisplatin ...
... (CD71, CARM1, PI3KCA&TK1), P-cadherin,  p53 
ESP Abstracts 2012
ESP Abstracts 2012
and with lower levels of ER expression and ...
... we explore the modifications and activation of  p53 
Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin
Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin
Illuzzi, Jennifer L.; Vickers, Cassie A.; Kmiec, Eric B.
and keystone regulators of the cell stress ...
... (LFS) patients with inherited mutations in  p53 
A novel genetic modifier of p53, mop1, results in embryonic lethality
A novel genetic modifier of p53, mop1, results in embryonic lethality
Evans, Susan C.; Liang, Min; Amos, Christopher; Gu, Xiangjun; Lozano, Guillermina
suggest risk modifiers at loci other than the ...
... of the human tumor suppressor protein  P53 
Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast
Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast
Kamoun, Yosra; Mabrouk, Imed; Delahodde, Agnes; Boukid, Fatma; Yacoubi-Hadj Amor, Ines; Mokdad-Gargouri, Raja; Gargouri, Ali
causes cell death of the yeast Saccharomyces ...
... Recent work has shown that the basal level of  p53 
p53 regulates LIF expression in human medulloblastoma cells
p53 regulates LIF expression in human medulloblastoma cells
Baxter, Euan W.; Milner, Jo
plays an important role in maternal reproduction ...
... Although the preoperative serum level of  p53 
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Peritherapeutic Serum p53 Antibody Titers are Predictors of Survival in Patients with Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Surgery
Yamashita, Kotaro; Makino, Tomoki; Tanaka, Koji; Yamasaki, Makoto; Yamamoto, Masaaki; Miyazaki, Yasuhiro; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro
antibodies (s- ...
... cells. HCT 116 colorectal cancer cells expressing  p53 
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Beaino, Wissam; Guo, Yunjun; Chang, Albert J.; Anderson, Carolyn J.
(+/+) and not expressing ...
... To further elucidate the significance of  p53 
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas
Feng, Yu-Zhen; Shiozawa, Tanri; Horiuchi, Akiko; Shih, Hsien-Chang; Miyamoto, Tsutomu; Kashima, Hiroyasu; Suzuki, Akihisa; Nikaido, Toshio; Konishi, Ikuo
mutation in endometrial carcinoma, we ...

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