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... induced claudin-low-like TNBC. The effect of  p53 
Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Wang, Sharon; Liu, Jeff C.; Kim, Danbi; Datti, Alessandro; Zacksenhaus, Eldad
mutation plus Pten deletion on mammary ...
... Introduction  p53 
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Zhao, Kai; Zhou, Yuxin; Qiao, Chen; Ni, Ting; Li, Zhiyu; Wang, Xiaotang; Guo, Qinglong; Lu, Na; Wei, Libin
plays important roles in regulating the metabolic ...
... Purpose  p53 
Delivery of a Monomeric p53 Subdomain with Mitochondrial Targeting Signals from Pro-Apoptotic Bak or Bax
Delivery of a Monomeric p53 Subdomain with Mitochondrial Targeting Signals from Pro-Apoptotic Bak or Bax
Matissek, Karina J.; Okal, Abood; Mossalam, Mohanad; Lim, Carol S.
targeted to the mitochondria is the fastest and ...
... that can restore biological activity of mutant  p53 
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Knowell, Ashley E; Patel, Divya; Morton, Derrick J; Sharma, Pankaj; Glymph, Shanora; Chaudhary, Jaideep
are an area of high interest given that mutant ...
... of cancer cells. However, the contribution of  p53 
Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis
Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis
Lahiry, Lakshmishri; Saha, Baisakhi; Chakraborty, Juni; Bhattacharyya, Sankar; Chattopadhyay, Sreya; Banerjee, Shuvomoy; Choudhuri, Tathagata; Mandal, Debaprasad; Bhattacharyya, Arindam; Sa, Gaurisankar; Das, Tanya
in mammary epithelial carcinoma cell apoptosis by ...
... are redundant and deeply interconnected. The  p53 
TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer
TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer
Hainaut, Pierre
protein, encoded by the TP53 tumor suppressor ...
... approach to treat cancers with dysfunctional  p53 
Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo
Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo
Lu, Yi; Zhang, Zhisong; Yan, Zhenwen; Chen, Li; Deng, Weimin; Lotze, Michael; Wang, Zhou; Lin, Xinli; Li, Lu-Yuan
tumor suppressor gene is to reinstate ...
... a variety of human cancers containing the mutant  p53 
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism
Hori, Makoto; Suzuki, Keiji; Udono, Masako U.; Yamauchi, Motohiro; Mine, Mariko; Watanabe, Masami; Kondo, Shigeo; Hozumi, Yutaka
(mt- ...
... harbor somatic mutations of the tumor suppressor  p53 
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
Guo, Gang; Cui, Yan
( ...
...  p53 
Senescence Regulation by the p53 Protein Family
Senescence Regulation by the p53 Protein Family
Qian, Yingjuan; Chen, Xinbin
, a guardian of the genome, exerts its tumor ...
... of mutant forms of the tumour suppressor  p53 
Upstream Targets in the p53 Pathway
Upstream Targets in the p53 Pathway
McCarthy, Anna R.; Lain, Sonia
or wild-type ...
... fate. Mutations within the TP53 (tumor suppressor  p53 
p53 regulates cytoskeleton remodeling to suppress tumor progression
p53 regulates cytoskeleton remodeling to suppress tumor progression
Araki, Keigo; Ebata, Takahiro; Guo, Alvin Kunyao; Tobiume, Kei; Wolf, Steven John; Kawauchi, Keiko
) gene leading to loss or gain of function (GOF) ...
... the function of tumor suppressor protein  p53 
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53
Dixit, Updesh; Liu, Zhihe; Pandey, Ashutosh K; Kothari, Ramesh; Pandey, Virendra N
. ...
... viability and subtle developmental defects of  p53 
Embryonic stem cells shed new light on the developmental roles of p53
Embryonic stem cells shed new light on the developmental roles of p53
Shin, Min Hwa; He, Yunlong; Huang, Jing
knockout mice suggest that ...
... poorly known. We identify the presence of three  p53 
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
Kelkar, Madhura G.; Thakur, Bhushan; Derle, Abhishek; Chatterjee, Sushmita; Ray, Pritha; De, Abhijit
binding sites on the human NIS promoter sequence ...
... recent evidence suggests that tumour suppressor  p53 
Crosstalk Between p53 and Mitochondrial Metabolism
Crosstalk Between p53 and Mitochondrial Metabolism
Itahana, Koji; Pervaiz, Shazib
actively participates in these communications. ...
... been shown to inactivate tumor suppressor protein  p53 
Mortalin-p53 Interaction as a Target for Liver Cancer Therapy
Mortalin-p53 Interaction as a Target for Liver Cancer Therapy
Lu, Wen-Jing; Lee, Nikki P.; Wadhwa, Renu; Luk, John M.
. ...
... the second as backup. Not necessarily so with  p53 
Resistance of mitochondrial p53 to dominant inhibition
Resistance of mitochondrial p53 to dominant inhibition
Heyne, Kristina; Schmitt, Katrin; Mueller, Daniel; Armbruester, Vivienne; Mestres, Pedro; Roemer, Klaus
. ...
... Background Mechanisms that inactivate the  p53 
Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Abramowitz, Julia; Neuman, Tzahi; Perlman, Riki; Ben-Yehuda, Dina
pathway in Acute Myeloid Leukemia (AML), other ...
... in breast cancer, we identified IBP was a novel  p53 
Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells
Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells
Yang, Mingzhen; Yuan, Fang; Li, Peng; Chen, Zhongjiao; Chen, An; Li, Shuhui; Hu, Chuanmin
target gene. ...
... Background The master regulator  p53 
Dissecting microregulation of a master regulatory network
Dissecting microregulation of a master regulatory network
Sinha, Amit U; Kaimal, Vivek; Chen, Jing; Jegga, Anil G
tumor-suppressor protein through coordination of ...
... Background  p53 
Characterization of a new mouse p53 variant: loss-of-function and gain-of-function
Characterization of a new mouse p53 variant: loss-of-function and gain-of-function
Chan, James Yi-Hsin; Chen, Ying-Chuan; Liu, Shu-Ting; Chou, Wei-Yuan; Ho, Ching-Liang; Huang, Shih-Ming
is a major tumor suppressor that is inactivated ...
... oxygen species during wound repair responses.  p53 
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
Mizuguchi, Yoshiaki; Specht, Susan; Lunz, John G, III; Isse, Kumiko; Corbitt, Natasha; Takizawa, Toshihiro; Demetris, Anthony J
is also widely recognized as the node in cellular ...
... Background The tumor suppressor protein  p53 
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
Loewer, Alexander; Karanam, Ketki; Mock, Caroline; Lahav, Galit
is activated by cellular stress. ...
... The  p53 
p53: Guardian of the Metabolome
p53: Guardian of the Metabolome
Poyurovsky, Masha V.; Prives, Carol
tumor suppressor protein is critically important ...

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