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...  p53 
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Giono, Luciana E.; Manfredi, James J.
is a widely conserved tumor suppressor protein ...
... of glutathione (GSH) and dependency of  p53 
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status
Banerjee, Kaushik; Das, Satyajit; Majumder, Saikat; Majumdar, Subrata; Biswas, Jaydip; Choudhuri, Soumitra Kumar
status on the modulation of GSH-mediated ...
... harbor mutations in the tumor suppressor  p53 
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Chander, Harish; Brien, Colin D; Truesdell, Peter; Watt, Kathleen; Meens, Jalna; Schick, Colleen; Germain, Doris; Craig, Andrew WB
, we tested whether ...
... accumulation of PTEN and its interaction with  p53 
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Das, Ranjita; Bhattacharya, Kaushik; Sarkar, Sayantani; Samanta, Suman Kumar; Pal, Bikas C.; Mandal, Chitra
/p73. ...
... of ING proteins is their cooperation with  p53 
Regulation of p53 by ING family members in suppression of tumor initiation and progression
Regulation of p53 by ING family members in suppression of tumor initiation and progression
Jafarnejad, Seyed Mehdi; Li, Gang
tumor suppressor protein in tumor suppression. ...
... mediate and regulate tumor suppression exerted by  p53 
The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches
The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches
Hünten, Sabine; Siemens, Helge; Kaller, Markus; Hermeking, Heiko
. ...
... pathways or cell cycle arrest. High frequency of  p53 
Sentinel Gene Within Cell Territory and Molecular Platforms in Cancer: Methylation Diversity of p53 Gene in Brain Tumors
Sentinel Gene Within Cell Territory and Molecular Platforms in Cancer: Methylation Diversity of p53 Gene in Brain Tumors
Mehdipour, Parvin; Karami, Fatemeh
gene aberrations in various types of cancer has ...
... Loss of function of  p53 
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Yu, Xin; Narayanan, Sumana; Vazquez, Alexei; Carpizo, Darren R.
, either through mutations in the gene or through ...
... The  p53 
p53
p53
Tsai, Wen-Wei; Barton, Michelle Craig
tumor suppressor is well known as the major ...
... Background  p53 
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
Brynczka, Christopher; Labhart, Paul; Merrick, B Alex
is recognized as a critical regulator of the cell ...
... Background  p53 
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Zhang, Lili; Nie, Linghu; Maki, Carl G
is a tumor suppressor and potent inhibitor of ...
... Methods We performed computer modeling of the  p53 
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
Golubovskaya, Vita M; Ho, Baotran; Zheng, Min; Magis, Andrew; Ostrov, David; Morrison, Carl; Cance, William G
peptide containing the site of interaction with ...
... Background The tumor suppressor protein  p53 
p53 induces distinct epigenetic states at its direct target promoters
p53 induces distinct epigenetic states at its direct target promoters
Vrba, Lukas; Junk, Damian J; Novak, Petr; Futscher, Bernard W
is a transcription factor that is mutated in many ...
... caused by the expression of BCR-ABL. Loss of  p53 
Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage
Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage
Kusio-Kobialka, Monika; Wolanin, Kamila; Podszywalow-Bartnicka, Paulina; Sikora, Ewa; Skowronek, Krzysztof; McKenna, Sharon L.; Ghizzoni, Massimo; Dekker, Frank J.; Piwocka, Katarzyna
has not been implicated as important for the ...
... reactivity against the tumor suppressor protein  p53 
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
Met, Özcan; Balslev, Eva; Flyger, Henrik; Svane, Inge Marie
in breast cancer patients (BCP) at the time point ...
... Tumor suppressor  p53 
The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism
The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism
Budanov, Andrei V.
is inactivated in most cancers and the critical ...
... Background The  p53 
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Chen, Xi; Chen, Jia; Gan, Siting; Guan, Huaji; Zhou, Yuan; Ouyang, Qi; Shi, Jue
pathway is differentially activated in response ...
... Background Activation of  p53 
HIPK2 modulates p53 activity towards pro-apoptotic transcription
HIPK2 modulates p53 activity towards pro-apoptotic transcription
Puca, Rosa; Nardinocchi, Lavinia; Sacchi, Ada; Rechavi, Gideon; Givol, David; D'Orazi, Gabriella
-mediated gene transcription is a critical ...
... further the interaction between BM2 and  p53 
The BM2 protein of influenza B virus interacts with p53 and inhibits its transcriptional and apoptotic activities
The BM2 protein of influenza B virus interacts with p53 and inhibits its transcriptional and apoptotic activities
Zhang, H.; Yu, H.; Wang, J.; Zhang, M.; Wang, X.; Ahmad, W.; Duan, M.; Guan, Z.
to confirm our previous studies using yeast ...
... linked at the molecular level. Results Blocking  p53 
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Villiard, Éric; Brinkmann, Henner; Moiseeva, Olga; Mallette, Frédérick A; Ferbeyre, Gerardo; Roy, Stéphane
signaling in axolotls using the ...
... Background The tumor suppressor  p53 
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Identification of new p53 target microRNAs by bioinformatics and functional analysis
Bisio, Alessandra; De Sanctis, Veronica; Del Vescovo, Valerio; Denti, Michela A; Jegga, Anil G; Inga, Alberto; Ciribilli, Yari
is a sequence-specific transcription factor that ...
... Purpose  p53 
Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment
Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment
Kraljević Pavelić, Sandra; Marjanović, Marko; Poznić, Miroslav; Kralj, Marijeta
gene plays a crucial role in the response to ...
... as well as induction of apoptosis through  p53 
PTTG/securin activates expression of p53 and modulates its function
PTTG/securin activates expression of p53 and modulates its function
Hamid, Tariq; Kakar, Sham S
-dependent and ...
... Background  p53 
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Ajay, Amrendra K; Upadhyay, Ankur K; Singh, Sandeep; Vijayakumar, Maleppillil V; Kumari, Ratna; Pandey, Vimal; Boppana, Ramanamurthy; Bhat, Manoj K
is the most studied tumor suppressor and its ...
... the wild-type (wt) form of the tumor suppressor  p53 
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
Wang, Fei; Liu, Jianfeng; Robbins, Delira; Morris, Kerri; Sit, Amos; Liu, Yong-Yu; Zhao, Yunfeng
, can translocate to mitochondria due to ...

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