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... of the genes responsible, such as K-ras,  P53 
Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells
Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells
Ukegawa, J.-I.; Takeuchi, Y.; Kusayanagi, S.; Mitamura, K.
, and DCC, may culminate in the establishment of ...
... of tumor suppressor proteins pRb and  p53 
Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
Baboci, Lorena; Boscolo-Rizzo, Paolo; Holzinger, Dana; Bertorelle, Roberta; Biasini, Lorena; Michel, Angelika; Schmitt, Markus; Spinato, Giacomo; Bussani, Rossana; Alemany, Laia; Tirelli, Giancarlo; Da Mosto, Maria Cristina; Del Mistro, Annarosa; Pawlita, Michael
. ...
... degradation of topoisomerase II β as well as  p53 
Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells
Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells
Jensen, Lars H; Dejligbjerg, Marielle; Hansen, Lasse T; Grauslund, Morten; Jensen, Peter B; Sehested, Maxwell
activation in a transcription dependent fashion ...
... accumulation of the tumor suppressor protein (  p53 
Design and synthesis of new coumarin–chalcone/NO hybrids of potential biological activity
Design and synthesis of new coumarin–chalcone/NO hybrids of potential biological activity
El-Sherief, Hany A.; Abuo-Rahma, Gamal El-Din A.; Shoman, Mai E.; Beshr, Eman A.; Abdel-baky, Rehab M.
) (Forrester et al. 1996). NO is also shown to ...
... et al. 2010). Mice deficient in both Brca1 and  p53 
Emerging Role of Brain Metastases in the Prognosis of Breast Cancer Patients
Emerging Role of Brain Metastases in the Prognosis of Breast Cancer Patients
Hambrecht, Amanda; Jandial, Rahul; Neman, Josh
, a tumor suppressor gene, in mammary epithelial ...
... protein kinases or tumor suppressor genes such as  p53 
Chronic opioid therapy in long-term cancer survivors
Chronic opioid therapy in long-term cancer survivors
Carmona-Bayonas, A.; Jiménez-Fonseca, P.; Castañón, E.; Ramchandani-Vaswani, A.; Sánchez-Bayona, R.; Custodio, A.; Calvo-Temprano, D.; Virizuela, J. A.
) [43, 64]. ...
... BBR3464 has also showed superior activity against  p53 
Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion
Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion
Kjellström, Johan; Oredsson, Stina M; Wennerberg, Johan
-mutant tumours[8]. ...
... a sensitivity of 100% and specificity of 94%.  p53 
Malignant Mesothelioma
Malignant Mesothelioma
Michael, Claire W.
may also be helpful in this differential ...
... Mustata et al. (2011) [37] showed PUMA (  p53 
In Vitro Anticancer Activity of Au, Ag Nanoparticles Synthesized Using Commelina nudiflora L. Aqueous Extract Against HCT-116 Colon Cancer Cells
In Vitro Anticancer Activity of Au, Ag Nanoparticles Synthesized Using Commelina nudiflora L. Aqueous Extract Against HCT-116 Colon Cancer Cells
Kuppusamy, Palaniselvam; Ichwan, Solachuddin J. A.; Al-Zikri, Putri Nur Hidayah; Suriyah, Wastuti Hidayati; Soundharrajan, Ilavenil; Govindan, Natanamurugaraj; Maniam, Gaanty Pragas; Yusoff, Mashitah M.
upregulated modulator of apoptosis) induces ...
... IHC 35/56/Up None Rb DFS IHC 220/49/Down Only in  p53 
Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors
Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors
Farnedi, Anna; Rossi, Silvia; Bertani, Nicoletta; Gulli, Mariolina; Silini, Enrico Maria; Mucignat, Maria Teresa; Poli, Tito; Sesenna, Enrico; Lanfranco, Davide; Montebugnoli, Lucio; Leonardi, Elisa; Marchetti, Claudio; Cocchi, Renato; Ambrosini-Spaltro, Andrea; Foschini, Maria Pia; Perris, Roberto
+/pRb− patients RUNX3 OS IHC/WB 108/46/Down None ...
... in a single gene, such as BRCA1/2, BRAF and  p53 
Genome wide in silico SNP-tumor association analysis
Genome wide in silico SNP-tumor association analysis
Qiu, Ping; Wang, Luquan; Kostich, Mitch; Ding, Wei; Simon, Jason S; Greene, Jonathan R
. ...
... IFI16 and JMY, two genes known to interact with  p53 
Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location
Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location
Gondret, Florence; Vincent, Annie; Houée-Bigot, Magalie; Siegel, Anne; Lagarrigue, Sandrine; Louveau, Isabelle; Causeur, David
in regulating cell cycle progression) as well as ...
... such as increasing VEGF and decreasing  P53 
MiR-21 modulates radiosensitivity of cervical cancer through inhibiting autophagy via the PTEN/Akt/HIF-1α feedback loop and the Akt-mTOR signaling pathway
MiR-21 modulates radiosensitivity of cervical cancer through inhibiting autophagy via the PTEN/Akt/HIF-1α feedback loop and the Akt-mTOR signaling pathway
Song, Lili; Liu, Shikai; Zhang, Liang; Yao, Hairong; Gao, Fangyuan; Xu, Dongkui; Li, Qian
expression [10] and suppressing radiation-induced ...
... has been mainly linked with germline mutations of  p53 
The Bioepidemiology of Multiple Primary Cancers
The Bioepidemiology of Multiple Primary Cancers
Travis, Lois B.; Ng, Andrea K.
(reviewed in Travis et al. ...
... inhibit apoptosis through the stabilization of  p53 
A role for NRAGE in NF-κB activation through the non-canonical BMP pathway
A role for NRAGE in NF-κB activation through the non-canonical BMP pathway
Matluk, Nicholas; Rochira, Jennifer A; Karaczyn, Aldona; Adams, Tamara; Verdi, Joseph M
and Mdm2 [21, 22]. ...
... four pathways [ER, progesterone receptor (PgR),  P53 
Identification of frequent somatic mutations in inflammatory breast cancer
Identification of frequent somatic mutations in inflammatory breast cancer
Matsuda, Naoko; Lim, Bora; Wang, Ying; Krishnamurthy, Savitri; Woodward, Wendy; Alvarez, Ricardo H.; Lucci, Anthony; Valero, Vicente; Reuben, James M.; Meric-Bernstam, Funda; Ueno, Naoto T.
, and TGF-β] were attenuated in inflammatory ...
... nodules, the loss of ovarian-like stroma, and  p53 
EUS Imaging in the Diagnosis of Pancreatic Masses
EUS Imaging in the Diagnosis of Pancreatic Masses
Kongkam, Pradermchai; Rerknimitr, Rungsun
immunoreactivity [54]. ...
... is activated by the tumor suppressor protein  P53 
Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases
Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases
Stark, Andreas M.; Tongers, Kerrin; Maass, Nicolai; Mehdorn, H. Maximilian; Held-Feindt, Janka
(Adachi et al. 1996; Dong et al. 1997; Jackson & ...
... the p21 protein. p21 is involved in several (  p53 
SNP association study in PMS2-associated Lynch syndrome
SNP association study in PMS2-associated Lynch syndrome
Broeke, Sanne W.; Elsayed, Fadwa A.; Pagan, Lisa; Olderode-Berends, Maran J. W.; Garcia, Encarna Gomez; Gille, Hans J. P.; Hest, Liselot P.; Letteboer, Tom G. W.; Kolk, Lizet E.; Mensenkamp, Arjen R.; Os, Theo A.; Spruijt, Liesbeth; Redeker, Bert J. W.; Suerink, Manon; Vos, Yvonne J.; Wagner, Anja; Wijnen, Juul T.; Steyerberg, E. W.; Tops, Carli M. J.; Wezel, Tom; Nielsen, Maartje
-independent) pathways as a tumor suppressor, ...
... an increase in the 'proapoptotic' proteins p21,  p53 
Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development
Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development
Bromberg, Jacqueline
and Bax is observed in the BLG-Cre/Stat3flox/- ...
... or that neither cell line expresses functional  p53 
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
Lister, Adam; Nedjadi, Taoufik; Kitteringham, Neil R; Campbell, Fiona; Costello, Eithne; Lloyd, Bryony; Copple, Ian M; Williams, Samantha; Owen, Andrew; Neoptolemos, John P; Goldring, Chris E; Park, B Kevin
protein [26, 27]. ...
... by combining it with IL-2, IL-12,  p53 
Preclinical Studies on Electrochemotherapy
Preclinical Studies on Electrochemotherapy
Serša, Gregor; Bosnjak, Masa; Čemažar, Maja; Heller, Richard
, or granulocyte macrophage colony-stimulating ...
... of several signaling pathways including Wnt,  p53 
Ataxia–telangiectasia group D complementing gene (ATDC) upregulates matrix metalloproteinase 9 (MMP-9) to promote lung cancer cell invasion by activating ERK and JNK pathways
Ataxia–telangiectasia group D complementing gene (ATDC) upregulates matrix metalloproteinase 9 (MMP-9) to promote lung cancer cell invasion by activating ERK and JNK pathways
Tang, Zhong-Ping; Cui, Quan-Zhe; Dong, Qian-Ze; Xu, Ke; Wang, En-Hua
, and PKC pathways in different tumors [10, 25, ...
... [23], and so on. In gastric cancer, TUSC7 is a  p53 
Long non-coding RNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinoma
Long non-coding RNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinoma
Wang, Yufeng; Liu, Zhikui; Yao, Bowen; Dou, Changwei; Xu, Meng; Xue, Yumo; Ding, Linglong; Jia, Yuli; Zhang, Hongyong; Li, Qing; Tu, Kangsheng; Jiao, Yang; Liu, Qingguang; Guo, Cheng
-regulated tumor suppressor that acts in part by ...
... with disease progression include mutations in  p53 
Molecular Pathology of Myeloproliferative Neoplasms
Molecular Pathology of Myeloproliferative Neoplasms
Bosler, David S.
, RB1, P16, c-MYC, and RAS; increased BCR–ABL1 ...

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