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... anticancer effects by simultaneously activating  p53 
Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1
Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1
Lee, Yuan-Chin; Chen, Ying-Jung; Huang, Chia-Hui; Chang, Long-Sen
and suppressing PI3K/AKT/mTOR and NF-κB pathways ...
... that DNA damage induces NDRG1 expression in a  p53 
Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620
Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620
Li, Qian; Chen, Hong
-dependent manner [5]. ...
... APEX has been used to detect β-thalassemia [10],  p53 
Robust SNP genotyping by multiplex PCR and arrayed primer extension
Robust SNP genotyping by multiplex PCR and arrayed primer extension
Podder, Mohua; Ruan, Jian; Tripp, Ben W; Chu, Zane E; Tebbutt, Scott J
[11], and BRCA1 mutations [12]. ...
... where the genes C6orf182 and SESN1 [Sestrin 1 (  p53 
Micro-array analyses decipher exceptional complex familial chromosomal rearrangement
Micro-array analyses decipher exceptional complex familial chromosomal rearrangement
Fauth, Christine; Gribble, Susan M.; Porter, Keith M.; Codina-Pascual, Montserrat; Ng, Bee Ling; Kraus, Jürgen; Uhrig, Sabine; Leifheit, Jürgen; Haaf, Thomas; Fiegler, Heike; Carter, Nigel P.; Speicher, Michael R.
-regulated protein PA26)] are located ...
... activator of Nanog transcription while Tcf3 and  p53 
Expression and Function of Pluripotency Genes in Adult Stem Cells
Expression and Function of Pluripotency Genes in Adult Stem Cells
Nigro, Antonio Lo; Roelandt, Philip; Verfaillie, Catherine M.
have a negative influence (Pan and Thomson ...
... to protect cells from apoptosis via the bcl-2/  p53 
Insulin-like growth factor I promotes cord blood T cell maturation through monocytes and inhibits their apoptosis in part through interleukin-6
Insulin-like growth factor I promotes cord blood T cell maturation through monocytes and inhibits their apoptosis in part through interleukin-6
Law, Helen KW; Tu, Wenwei; Liu, Enmei; Lau, Yu Lung
pathway [62]. ...
... Inclusion of additional biomarkers, such as  p53 
Mammographic microcalcifications and breast cancer tumorigenesis: a radiologic-pathologic analysis
Mammographic microcalcifications and breast cancer tumorigenesis: a radiologic-pathologic analysis
Naseem, Madiha; Murray, Joshua; Hilton, John F; Karamchandani, Jason; Muradali, Derek; Faragalla, Hala; Polenz, Chanele; Han, Dolly; Bell, David C; Brezden-Masley, Christine
and further genetic analysis would have further ...
... the expression of the cell cycle regulator  p53 
Tissue Microarray for Biomarker Studies in Salivary Gland Tumors
Tissue Microarray for Biomarker Studies in Salivary Gland Tumors
Vargas, Pablo Agustin; Fonseca, Felipe Paiva; Almeida, Oslei Paes; Speight, Paul M.
has been proved to be significantly correlated ...
... probably as a result of cyclin D1 overexpression;  p53 
Eye and the Ocular Adnexa
Eye and the Ocular Adnexa
Coupland, Sarah E.; Dijk, Marijke R.
signalling, possibly as a consequence of MDM2 ...
... BCL2) while for others this is not evident (i.e.  p53 
Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis
Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis
Lips, Esther H; van Eijk, Ronald; de Graaf, Eelco JR; Oosting, Jan; de Miranda, Noel FCC; Karsten, Tom; van de Velde, Cornelis J; Eilers, Paul HC; Tollenaar, Rob AEM; van Wezel, Tom; Morreau, Hans
, BMP7). ...
... 13 Melanoma 7 1.4E-3 14 Cell cycle 8 5.9E-3 15  p53 
miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing–remitting multiple sclerosis
miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing–remitting multiple sclerosis
Ahmadian-Elmi, Maryam; Bidmeshki Pour, Ali; Naghavian, Reza; Ghaedi, Kamran; Tanhaei, Somayeh; Izadi, Tayebeh; Nasr-Esfahani, Mohammad Hossein
signaling pathway 6 6.4E-3 16 mTOR signaling ...
... for these three chemicals is Ccng1, which is a  p53 
A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens
A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens
Schaap, Mirjam M.; Wackers, Paul F. K.; Zwart, Edwin P.; Huijskens, Ilse; Jonker, Martijs J.; Hendriks, Giel; Breit, Timo M.; Steeg, Harry; Water, Bob; Luijten, Mirjam
-responsive gene and can be linked to a DNA ...
... ablative therapy. Abnormal proliferation and  p53 
MicroRNA-143 and -205 Expression in Neosquamous Esophageal Epithelium Following Argon Plasma Ablation of Barrett’s Esophagus
MicroRNA-143 and -205 Expression in Neosquamous Esophageal Epithelium Following Argon Plasma Ablation of Barrett’s Esophagus
Dijckmeester, Willem A.; Wijnhoven, Bas P. L.; Watson, David I.; Leong, Mary P.; Michael, Michael Z.; Mayne, George C.; Bright, Tim; Astill, David; Hussey, Damian J.
staining has been detected in squamous islands ...
... as the inactivation of tumor suppressors (e.g.  p53 
Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?
Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?
Grimm, Martin; Cetindis, Marcel; Lehmann, Max; Biegner, Thorsten; Munz, Adelheid; Teriete, Peter; Kraut, Wiebke; Reinert, Siegmar
) rather than the primary generation of much ...
... the phosphorylation of several targets, including  p53 
A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation
A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation
Benzina, Sami; Pitaval, Amandine; Lemercier, Claudie; Lustremant, Celine; Frouin, Vincent; Wu, Ning; Papine, Alexandre; Soussaline, Françoise; Romeo, Paul-Henri; Gidrol, Xavier
, NBS1, and H2AX [36–38]. ...
... of molecules including Bcl-2 family proteins,  P53 
Effects of Recombinant MAP30 on Cell Proliferation and Apoptosis of Human Colorectal Carcinoma LoVo Cells
Effects of Recombinant MAP30 on Cell Proliferation and Apoptosis of Human Colorectal Carcinoma LoVo Cells
Fan, Jian-Ming; Luo, Jun; Xu, Jun; Zhu, Sha; Zhang, Qiao; Gao, De-Fu; Xu, Yu-Bao; Zhang, Gai-Ping
, and P21. ...
... a combination of the following keywords: TP53,  P53 
Polymorphisms of TP53 codon 72 with breast carcinoma risk: evidence from 12226 cases and 10782 controls
Polymorphisms of TP53 codon 72 with breast carcinoma risk: evidence from 12226 cases and 10782 controls
Zhuo, Wenlei; Zhang, Yunsong; Xiang, Zhaolan; Cai, Lei; Chen, Zhengtang
, codon 72, breast, carcinoma, neoplasm, tumor, ...
... of caspase-3 [23, 26, 27]. IL-1β-induced  p53 
Resveratrol protects rabbit articular chondrocyte against sodium nitroprusside-induced apoptosis via scavenging ROS
Resveratrol protects rabbit articular chondrocyte against sodium nitroprusside-induced apoptosis via scavenging ROS
Liang, Qian; Wang, Xiao-ping; Chen, Tong-sheng
- and ROS-dependent apoptosis can also be ...
... with cyclin kinase inhibitor p21WAF1/CIP1, though  p53 
Reciprocal role of cyclins and cyclin kinase inhibitor p21WAF1/CIP1 on lymphocyte proliferation, allo-immune activation and inflammation
Reciprocal role of cyclins and cyclin kinase inhibitor p21WAF1/CIP1 on lymphocyte proliferation, allo-immune activation and inflammation
Khanna, Ashwani K
and cyclin kinase inhibitors (p27, p16) have been ...
... for cyclin D1) was reported in 78 % and loss of  p53 
Multidisciplinary Management of Hypopharyngeal Carcinoma
Multidisciplinary Management of Hypopharyngeal Carcinoma
Hamoir, Marc; Machiels, Jean-Pascal; Schmitz, Sandra; Grégoire, Vincent
heterozygosity in 70 % [13]. ...
... and other melanoma markers were also negative.  P53 
Three uncommon adrenal incidentalomas: a 13-year surgical pathology review
Three uncommon adrenal incidentalomas: a 13-year surgical pathology review
Kanthan, Rani; Senger, Jenna-Lynn; Kanthan, Selliah
and Ki67 were moderately expressed in the ...
... (Chen et al. 1992), and activation of  p53 
Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death
Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death
Lash, Lawrence H.
(Healy et al. 1998; Dmitrieva, Michea and Burg ...
... 26.2 ) as well as the tumor-suppressor protein  p53 
Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
Klebe, Gerhard
. ...
... activation of downstream effectors such as  p53 
Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism
Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism
Fahkri, Hajar; Zhang, Bingbing; Fajol, Abul; Hernando, Nati; Elvira, Bernat; Mannheim, Julia G.; Pichler, Bernd J.; Daniel, Christoph; Amann, Kerstin; Hirao, Atsushi; Haight, Jillian; Mak, Tak W.; Lang, Florian; Föller, Michael
, Mdm2, or Brca1 results in DNA repair, cell ...
... inactivates negative growth regulators like  p53 
Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2
Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2
Li, Weihua; Miao, Xiaohui; Qi, Zhongtian; Zeng, Wenting; Liang, Jianxin; Liang, Zengwei
[5] and facilitates the accumulation of DNA ...

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