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... et al. 2002). β-Syn may display an anti-apoptotic  p53 
Inhibitors of α-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson’s disease and related disorders
Inhibitors of α-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson’s disease and related disorders
Amer, Dena A. M.; Irvine, G. Brent; El-Agnaf, Omar M. A.
-dependent phenotype in TSM1 neurons, in addition ...
... loss of tumor suppressor genes such as VHL and  p53 
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma
Feichtinger, Rene' G; Zimmermann, Franz; Mayr, Johannes A; Neureiter, Daniel; Hauser-Kronberger, Cornelia; Schilling, Freimut H; Jones, Neil; Sperl, Wolfgang; Kofler, Barbara
or activation of oncogenes results in ...
... are involved in the FAS-FASL interaction and the  p53 
Transcriptional profiles in bursal B-lymphoid DT40 cells infected with very virulent infectious bursal disease virus
Transcriptional profiles in bursal B-lymphoid DT40 cells infected with very virulent infectious bursal disease virus
Quan, Rong; Zhu, Shanshan; Wei, Li; Wang, Jing; Yan, Xu; Li, Zixuan; Liu, Jue
signaling pathway to contribute to the apoptotic ...
... investigators found that the occurrence of  p53 
The Multifaceted Role of Cancer Associated Fibroblasts in Tumor Progression
The Multifaceted Role of Cancer Associated Fibroblasts in Tumor Progression
Eikesdal, Hans Petter; Kalluri, Raghu
mutations in fibroblasts sensitize tumors to ...
... oxidative stress and decreased expression of  p53 
Sustained early disruption of mitochondrial function contributes to arsenic-induced prostate tumorigenesis
Sustained early disruption of mitochondrial function contributes to arsenic-induced prostate tumorigenesis
Singh, B.; Kulawiec, M.; Owens, K. M.; Singh, A.; Singh, K. K.
in arsenic-transformed cells as an underlying ...
... therapy and biological findings (e.g. lack of  p53 
Congenital tumours involving the head, neck and central nervous system
Congenital tumours involving the head, neck and central nervous system
Vazquez, Elida; Castellote, Amparo; Mayolas, Nuria; Carreras, Elena; Peiro, Jose Luis; Enríquez, Goya
and EGFR overexpression in tumour cells) all ...
... TP53, that encodes the tumor suppressor protein  p53 
Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations
Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations
Balendran, S.; Liebmann-Reindl, S.; Berghoff, A. S.; Reischer, T.; Popitsch, N.; Geier, C. B.; Kenner, L.; Birner, P.; Streubel, B.; Preusser, M.
, is the most frequently altered gene in serous ...
... including p55 blk (Blk), p59 fyn (Fyn) and  p53 
Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes
Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes
Hsueh, Robert C; Hammill, Adrienne M; Lee, Jamie A; Uhr, Jonathan W; Scheuermann, Richard H
/56 lyn (Lyn) of the Src family [31], Btk of the ...
... degradation of the tumour suppressor proteins  p53 
Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck
Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck
Wilting, Saskia M; Smeets, Serge J; Snijders, Peter JF; van Wieringen, Wessel N; van de Wiel, Mark A; Meijer, Gerrit A; Ylstra, Bauke; Leemans, C René; Meijer, Chris JLM; Brakenhoff, Ruud H; Braakhuis, Boudewijn JM; Steenbergen, Renske DM
and pRb, respectively. ...
... difference in immunoreactivity to Fas, Fas-L,  P53 
Apoptosis Inhibitor Expressed by Macrophages Tempers Autoimmune Colitis and the Risk of Colitis-Based Carcinogenesis in TCRα−/− Mice
Apoptosis Inhibitor Expressed by Macrophages Tempers Autoimmune Colitis and the Risk of Colitis-Based Carcinogenesis in TCRα−/− Mice
Haruta, Ikuko; Shibata, Noriyuki; Kato, Yoichiro; Tanaka, Masanori; Kobayashi, Makio; Oguma, Hidetoshi; Shiratori, Keiko
, Bax, or caspase-3 between TCRα−/− × AIM−/− and ...
... HSCT (allo-HSCT) as a result of harboring  P53 
Detection of ETV6 gene rearrangements in adult acute lymphoblastic leukemia
Detection of ETV6 gene rearrangements in adult acute lymphoblastic leukemia
Zhou, Min-hang; Gao, Li; Jing, Yu; Xu, Yuan-yuan; Ding, Yi; Wang, Nan; Wang, Wei; Li, Mian-yang; Han, Xiao-ping; Sun, Jun-zhong; Wang, Li-li; Yu, Li
mutation and complex karyotype, which predict ...
... frequent IDH-1 (isocitrate dehydrogenase-1) and  p53 
Introduction to Basic Neuropathology
Introduction to Basic Neuropathology
Yachnis, Anthony T.
mutations as an early tumorigenic event [54, ...
... (4). Overexpression of E6 promotes degradation of  p53 
Screening for Molecular Markers of Cervical Papillomavirus Infection: Overview of Methods and Their Clinical Implications
Screening for Molecular Markers of Cervical Papillomavirus Infection: Overview of Methods and Their Clinical Implications
Dehn, Donna; Taylor, Adriann; Fischer, Timothy J.; Malinowski, Douglas P.; Shroyer, Kenneth R.
, resulting in unchecked cell cycle progression ...
... syndrome, caused by an inherited mutation in the  p53 
Distribution, Causes and Prevention of Individual Neoplasms
Distribution, Causes and Prevention of Individual Neoplasms
Boffetta, Paolo; Boccia, Stefania; Vecchia, Carlo
gene, and other rare genetic syndromes. ...
... protein kinase 14 (MAPK14), and tumor protein  p53 
Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker
Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker
Khan, Rizma; Siddiqui, Nadir Naveed; Haq, Ahtesham; Rahman, M. Ataur
(TP53), which bestowed with critical ...
... promote mutation of cancer-related genes (e.g.,  p53 
Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal Cancer
Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal Cancer
Sugimachi, Keishi; Matsumura, Tae; Shimamura, Teppei; Hirata, Hidenari; Uchi, Ryutaro; Ueda, Masami; Sakimura, Shotaro; Iguchi, Tomohiro; Eguchi, Hidetoshi; Masuda, Takaaki; Morita, Kazutoyo; Takenaka, Kenji; Maehara, Yoshihiko; Mori, Masaki; Mimori, Koshi
, KRAS). ...
... genomic instability and alterations of the  p53 
Expression of inflammatory secretory phospholipase A2 and cytosolic phospholipase A2 in premalignant and malignant Barrett’s oesophagus
Expression of inflammatory secretory phospholipase A2 and cytosolic phospholipase A2 in premalignant and malignant Barrett’s oesophagus
Lagorce-Pagès, Christine; Paraf, François; Wendum, Dominique; Martin, Antoine; Fléjou, Jean-François
tumour suppressor gene [17]. ...
... and related anti-apoptotic proteins, loss of  p53 
Altered Apoptosis in AML
Altered Apoptosis in AML
Mesa, Ruben A.; Kaufmann, Scott H.
function, mutation of Ras alleles (stimulating ...
... (IFN-γ), ceramide and oncogenes such as  p53 
Shear stress attenuates apoptosis due to TNFα, oxidative stress, and serum depletion via death-associated protein kinase (DAPK) expression
Shear stress attenuates apoptosis due to TNFα, oxidative stress, and serum depletion via death-associated protein kinase (DAPK) expression
Rennier, Keith; Ji, Julie Y
[19-23]. ...
... mechanism which is not mediated by  p53 
Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway
Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway
Liao, Rifang; Yan, Fengxia; Zeng, Zhuanping; Farhan, Mohd; Little, Peter; Quirion, Remi; Srivastava, Lalit K.; Zheng, Wenhua
[55, 56]. ...
... binding and inactivation of tumor suppressors,  p53 
The physical state of HPV16 infection and its clinical significance in cancer precursor lesion and cervical carcinoma
The physical state of HPV16 infection and its clinical significance in cancer precursor lesion and cervical carcinoma
Li, Wei; Wang, Wei; Si, Mani; Han, Linfei; Gao, Qinglei; Luo, Aiyue; Li, Yan; Lu, Yunping; Wang, Shixuan; Ma, Ding
and retinoblastoma protein (Rb), by the ...
... found in the genes for tumor suppressors such as  p53 
Cytosine Methylation and DNA Repair
Cytosine Methylation and DNA Repair
Walsh, C. P.; Xu, G. L.
and the retinoblastoma protein, causing cancer. ...
... BRCA1 has been shown to influence apoptosis in a  p53 
BRCA1 Zinc RING Finger Domain Disruption Alters Caspase Response in Ovarian Surface Epithelial Cells
BRCA1 Zinc RING Finger Domain Disruption Alters Caspase Response in Ovarian Surface Epithelial Cells
Johnson, Nicole C; Kruk, Patricia A
independent manner [13]. ...
... „Long intergenic non-protein coding RNA,  P53 
Genetisch bedingte Pankreaserkrankungen
Genetisch bedingte Pankreaserkrankungen
Damm, M.; Michl, P.; Rosendahl, J.
induced transcript“ NR5A2 „Nuclear receptor ...
... dynamics, DNA replication, chromosome dynamics,  p53 
The substrates of Plk1, beyond the functions in mitosis
The substrates of Plk1, beyond the functions in mitosis
Liu, X. Shawn; Song, Bing; Liu, Xiaoqi
regulation, and recovery from the G2 DNA-damage ...

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