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... around CpG islands. It is unclear whether  methylation 
Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo
Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo
Du, Yantao; Liu, Zhaojun; Gu, Liankun; Zhou, Jing; Zhu, Bu-dong; Ji, Jiafu; Deng, Dajun
of these CpG islands represses miR ...
... Background Aberrant DNA  methylation 
DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
Amatruda, James F; Ross, Julie A; Christensen, Brock; Fustino, Nicholas J; Chen, Kenneth S; Hooten, Anthony J; Nelson, Heather; Kuriger, Jacquelyn K; Rakheja, Dinesh; Frazier, A Lindsay; Poynter, Jenny N
is a prominent feature of many cancers, ...
... poor patient’s prognosis. Beside promoter  methylation 
Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme
Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme
Oberstadt, Moritz C; Bien-Möller, Sandra; Weitmann, Kerstin; Herzog, Susann; Hentschel, Katharina; Rimmbach, Christian; Vogelgesang, Silke; Balz, Ellen; Fink, Matthias; Michael, Heike; Zeden, Jan-Philip; Bruckmüller, Henrike; Werk, Anneke N; Cascorbi, Ingolf; Hoffmann, Wolfgang; Rosskopf, Dieter; Schroeder, Henry WS; Kroemer, Heyo K
of the O 6 ...
... potential for the development of new DNA  methylation 
A panel of genes methylated with high frequency in colorectal cancer
A panel of genes methylated with high frequency in colorectal cancer
Mitchell, Susan M; Ross, Jason P; Drew, Horace R; Ho, Thu; Brown, Glenn S; Saunders, Neil FW; Duesing, Konsta R; Buckley, Michael J; Dunne, Rob; Beetson, Iain; Rand, Keith N; McEvoy, Aidan; Thomas, Melissa L; Baker, Rohan T; Wattchow, David A; Young, Graeme P; Lockett, Trevor J; Pedersen, Susanne K; LaPointe, Lawrence C; Molloy, Peter L
biomarkers or panels to improve the ...
... Background  Methylation 
MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma
MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma
Skiriute, Daina; Vaitkiene, Paulina; Saferis, Viktoras; Asmoniene, Virginija; Skauminas, Kestutis; Deltuva, Vytenis Pranas; Tamasauskas, Arimantas
of promoter region is the major mechanism ...
... of PDAC and examined their promoters for  methylation 
Epigenetic regulation and role of metastasis suppressor genes in pancreatic ductal adenocarcinoma
Epigenetic regulation and role of metastasis suppressor genes in pancreatic ductal adenocarcinoma
Mardin, Wolf Arif; Haier, Joerg; Mees, Soeren Torge
and its use in PDAC detection. ...
... Most experiments to measure DNA  methylation 
Why do results conflict regarding the prognostic value of the methylation status in colon cancers? the role of the preservation method
Why do results conflict regarding the prognostic value of the methylation status in colon cancers? the role of the preservation method
Tournier, Benjamin; Chapusot, Caroline; Courcet, Emilie; Martin, Laurent; Lepage, Côme; Faivre, Jean; Piard, Françoise
rely on the sodium bisulfite conversion ...
... which are frequently silenced by promoter  methylation 
Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer
Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer
Veeck, Jürgen; Wild, Peter J; Fuchs, Thomas; Schüffler, Peter J; Hartmann, Arndt; Knüchel, Ruth; Dahl, Edgar
in this disease. ...
... associated with frequent changes in DNA  methylation 
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation
Rauscher, Garth H.; Kresovich, Jacob K.; Poulin, Matthew; Yan, Liying; Macias, Virgilia; Mahmoud, Abeer M.; Al-Alem, Umaima; Kajdacsy-Balla, Andre; Wiley, Elizabeth L.; Tonetti, Debra; Ehrlich, Melanie
but the extent of very early alterations ...
... Background DNA  methylation 
Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists
Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists
Mossman, David; Kim, Kyu-Tae; Scott, Rodney J
and histone acetylation are epigenetic ...
... Background Aberrant DNA  methylation 
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
Klajic, Jovana; Fleischer, Thomas; Dejeux, Emelyne; Edvardsen, Hege; Warnberg, Fredrik; Bukholm, Ida; Lønning, Per Eystein; Solvang, Hiroko; Børresen-Dale, Anne-Lise; Tost, Jörg; Kristensen, Vessela N
of regulatory genes has frequently been ...
... EFS (embryonal Fyn-associated substrate)  methylation 
EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation
EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation
Neumann, Lisa C; Weinhäusel, Andreas; Thomas, Stefanie; Horsthemke, Bernhard; Lohmann, Dietmar R; Zeschnigk, Michael
analyses in UM, cultured uveal ...
... Background RASSF1A gene silencing by DNA  methylation 
Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors
Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors
Malpeli, Giorgio; Amato, Eliana; Dandrea, Mario; Fumagalli, Caterina; Debattisti, Valentina; Boninsegna, Letizia; Pelosi, Giuseppe; Falconi, Massimo; Scarpa, Aldo
has been suggested as a major event in ...
... analysis tool for the detection of DNA  methylation 
Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM
Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM
Kristensen, Lasse S; Wojdacz, Tomasz K; Thestrup, Britta B; Wiuf, Carsten; Hager, Henrik; Hansen, Lise Lotte
. ...
... intra-patient heterogeneity of LINE-1  methylation 
LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer
LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer
Matsunoki, Aika; Kawakami, Kazuyuki; Kotake, Masanori; Kaneko, Mami; Kitamura, Hirotaka; Ooi, Akishi; Watanabe, Go; Minamoto, Toshinari
in CRC and to understand its biological ...
... in various cancers, however,  methylation 
Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients
Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients
Savio, Andrea J.; Daftary, Darshana; Dicks, Elizabeth; Buchanan, Daniel D.; Parfrey, Patrick S.; Young, Joanne P.; Weisenberger, Daniel; Green, Roger C.; Gallinger, Steven; McLaughlin, John R.; Knight, Julia A.; Bapat, Bharati
-dependent regulation of these genes in ...
... HT29, HCT116, SW48, LS180, and LoVo). DNA  methylation 
Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells
Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells
Habano, Wataru; Gamo, Toshie; Terashima, Jun; Sugai, Tamotsu; Otsuka, Koki; Wakabayashi, Go; Ozawa, Shogo
status was also examined by bisulfite ...
... promoter activity and its relation to DNA  methylation 
hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis
hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis
de Wilde, Jillian; Kooter, Jan M; Overmeer, Renée M; Claassen-Kramer, Debbie; Meijer, Chris JLM; Snijders, Peter JF; Steenbergen, Renske DM
as one of the potential mechanisms ...
... disease like cancer. Alterations in DNA  methylation 
Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients
Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients
Cappetta, Mónica; Berdasco, María; Hochmann, Jimena; Bonilla, Carolina; Sans, Mónica; Hidalgo, Pedro C; Artagaveytia, Nora; Kittles, Rick; Martínez, Miguel; Esteller, Manel; Bertoni, Bernardo
patterns have been associated with ...
... This study examines whether gene-promoter  methylation 
Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation
Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation
Taioli, Emanuela; Ragin, Camille; Wang, Xiao-hong; Chen, Jiangying; Langevin, Scott M; Brown, Ashley R; Gollin, Susanne M; Garte, Seymour; Sobol, Robert W
of tumor DNA correlates with survival and ...
... in HCT116 and DLD-1 CRC cell lines. DNA  methylation 
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer
Rawluszko, Agnieszka A; Bujnicka, Katarzyna E; Horbacka, Karolina; Krokowicz, Piotr; Jagodziński, Paweł P
levels of the CpG island in the promoter ...
... can affect the spread of retroelement  methylation 
The 5'-end transitional CpGs between the CpG islands and retroelements are hypomethylated in association with loss of heterozygosity in gastric cancers
The 5'-end transitional CpGs between the CpG islands and retroelements are hypomethylated in association with loss of heterozygosity in gastric cancers
Kim, Young-Ho; Hong, Seung-Jin; Jung, Yu-Chae; Kim, Sung-Ja; Seo, Eun-Joo; Choi, Sang-Wook; Rhyu, Mun-Gan
in the 5'-end transitional area between ...
... versus neoplastic cells, we investigated  methylation 
DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells
DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells
Nordström, Lena; Andersson, Elin; Kuci, Venera; Gustavsson, Elin; Holm, Karolina; Ringnér, Markus; Guldberg, Per; Ek, Sara
and histone modifications related to the ...
... Background The  methylation 
A cross-sectional study of global DNA methylation and risk of colorectal adenoma
A cross-sectional study of global DNA methylation and risk of colorectal adenoma
King, Will D; Ashbury, Janet E; Taylor, Sherryl A; Tse, M Yat; Pang, Stephen C; Louw, Jacob A; Vanner, Stephen J
of DNA is recognized as a key epigenetic ...
... diagnostic markers for UC based on DNA  methylation 
Diagnostic markers of urothelial cancer based on DNA methylation analysis
Diagnostic markers of urothelial cancer based on DNA methylation analysis
Chihara, Yoshitomo; Kanai, Yae; Fujimoto, Hiroyuki; Sugano, Kokichi; Kawashima, Kiyotaka; Liang, Gangning; Jones, Peter A; Fujimoto, Kiyohide; Kuniyasu, Hiroki; Hirao, Yoshihiko
. ...

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