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... genetic changes to gene expression, DNA  methylation 
Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome
Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome
Cheung, Warren A.; Shao, Xiaojian; Morin, Andréanne; Siroux, Valérie; Kwan, Tony; Ge, Bing; Aïssi, Dylan; Chen, Lu; Vasquez, Louella; Allum, Fiona; Guénard, Frédéric; Bouzigon, Emmanuelle; Simon, Marie-Michelle; Boulier, Elodie; Redensek, Adriana; Watt, Stephen; Datta, Avik; Clarke, Laura; Flicek, Paul; Mead, Daniel; Paul, Dirk S.; Beck, Stephan; Bourque, Guillaume; Lathrop, Mark; Tchernof, André; Vohl, Marie-Claude; Demenais, Florence; Pin, Isabelle; Downes, Kate; Stunnenberg, Hendrick G.; Soranzo, Nicole; Pastinen, Tomi; Grundberg, Elin
, and histone marks but these ...
... Background CpG  methylation 
Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation
Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation
Busche, Stephan; Shao, Xiaojian; Caron, Maxime; Kwan, Tony; Allum, Fiona; Cheung, Warren A.; Ge, Bing; Westfall, Susan; Simon, Marie-Michelle; Barrett, Amy; Bell, Jordana T.; McCarthy, Mark I.; Deloukas, Panos; Blanchette, Mathieu; Bourque, Guillaume; Spector, Timothy D.; Lathrop, Mark; Pastinen, Tomi; Grundberg, Elin; The Multiple Tissue Human Expression Resource
variation is involved in human trait ...
... epigenome. In the female germline, DNA  methylation 
Transcription and chromatin determinants of de novo DNA methylation timing in oocytes
Transcription and chromatin determinants of de novo DNA methylation timing in oocytes
Gahurova, Lenka; Tomizawa, Shin-ichi; Smallwood, Sébastien A.; Stewart-Morgan, Kathleen R.; Saadeh, Heba; Kim, Jeesun; Andrews, Simon R.; Chen, Taiping; Kelsey, Gavin
is acquired late in oogenesis from an ...
... the effects of 5-azacytidine on DNA  methylation 
DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML
DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML
Lund, Kirstin; Cole, John J; VanderKraats, Nathan D; McBryan, Tony; Pchelintsev, Nikolay A; Clark, William; Copland, Mhairi; Edwards, John R; Adams, Peter D
and gene expression using whole-genome ...
... for individual-specific genome-wide DNA  methylation 
Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements
Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements
Zhang, Weiwei; Spector, Tim D; Deloukas, Panos; Bell, Jordana T; Engelhardt, Barbara E
profiles have enabled epigenome-wide ...
... DNA  methylation 
Methylation-specific multiplex ligation-dependent probe amplification identifies promoter methylation events associated with survival in glioblastoma
Methylation-specific multiplex ligation-dependent probe amplification identifies promoter methylation events associated with survival in glioblastoma
Rankeillor, K. L.; Cairns, D. A.; Loughrey, C.; Short, S. C.; Chumas, P.; Ismail, A.; Chakrabarty, A.; Lawler, S. E.; Roberts, P.
plays an important role in cancer biology ...
... will be increasingly important. DNA  methylation 
Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study
Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study
Collerton, Joanna; Gautrey, Hannah E.; Otterdijk, Sanne D.; Davies, Karen; Martin-Ruiz, Carmen; Zglinicki, Thomas; Kirkwood, Thomas B. L.; Jagger, Carol; Mathers, John C.; Strathdee, Gordon
patterns within genomic DNA change during ...
... shared gene expression and a lack of  methylation 
Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells
Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells
Lee, Shih-Han; Appleby, Vanessa; Jeyapalan, Jennie N.; Palmer, Roger D.; Nicholson, James C.; Sottile, Virginie; Gao, Erning; Coleman, Nicholas; Scotting, Paul J.
of imprinted genes, including SNRPN. ...
... particular, histone lysine and arginine  methylation 
Dynamic protein methylation in chromatin biology
Dynamic protein methylation in chromatin biology
Ng, S. S.; Yue, W. W.; Oppermann, U.; Klose, R. J.
play important roles in regulating ...
... disomy of chromosome 7. We measured DNA  methylation 
Genome-wide methylation analysis in Silver–Russell syndrome patients
Genome-wide methylation analysis in Silver–Russell syndrome patients
Prickett, A. R.; Ishida, M.; Böhm, S.; Frost, J. M.; Puszyk, W.; Abu-Amero, S.; Stanier, P.; Schulz, R.; Moore, G. E.; Oakey, R. J.
in 18 SRS patients at >485,000 CpG sites ...
... Previous studies have indicated that DNA  methylation 
Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2
Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2
Thakur, Avinash; Mackin, Sarah-Jayne; Irwin, Rachelle E.; O’Neill, Karla M.; Pollin, Gareth; Walsh, Colum
lost from gDMRs could not be restored by ...
... for genomic regions at which PBL DNA  methylation 
Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment
Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment
Silver, Matt J; Kessler, Noah J; Hennig, Branwen J; Dominguez-Salas, Paula; Laritsky, Eleonora; Baker, Maria S; Coarfa, Cristian; Hernandez-Vargas, Hector; Castelino, Jovita M; Routledge, Michael N; Gong, Yun Yun; Herceg, Zdenko; Lee, Yong Sun; Lee, Kwanbok; Moore, Sophie E; Fulford, Anthony J; Prentice, Andrew M; Waterland, Robert A
is affected by season of conception in ...
... with considerable changes in global DNA  methylation 
DNA methylation in mouse embryonic stem cells and development
DNA methylation in mouse embryonic stem cells and development
Latham, Tom; Gilbert, Nick; Ramsahoye, Bernard
levels at times of genomic ...
... Background DNA  methylation 
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
Bell, Jordana T; Pai, Athma A; Pickrell, Joseph K; Gaffney, Daniel J; Pique-Regi, Roger; Degner, Jacob F; Gilad, Yoav; Pritchard, Jonathan K
is an essential epigenetic mechanism ...
... Background DNA  methylation 
A genome-wide survey of DNA methylation in hexaploid wheat
A genome-wide survey of DNA methylation in hexaploid wheat
Gardiner, Laura-Jayne; Quinton-Tulloch, Mark; Olohan, Lisa; Price, Jonathan; Hall, Neil; Hall, Anthony
is an important mechanism of epigenetic ...
... in old age are poorly understood. DNA  methylation 
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
Hahn, Oliver; Grönke, Sebastian; Stubbs, Thomas M.; Ficz, Gabriella; Hendrich, Oliver; Krueger, Felix; Andrews, Simon; Zhang, Qifeng; Wakelam, Michael J.; Beyer, Andreas; Reik, Wolf; Partridge, Linda
could play an important role in mediating ...
... and de novo tumour-specific promoter  methylation 
Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma
Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma
Ricketts, Christopher J; Morris, Mark R; Gentle, Dean; Shuib, Salwati; Brown, Michael; Clarke, Noel; Wei, Wenbin; Nathan, Paul; Latif, Farida; Maher, Eamonn R
of renal TSGs. ...
... quantifying genome-wide patterns of DNA  methylation 
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Hannon, Eilis; Dempster, Emma; Viana, Joana; Burrage, Joe; Smith, Adam R.; Macdonald, Ruby; St Clair, David; Mustard, Colette; Breen, Gerome; Therman, Sebastian; Kaprio, Jaakko; Toulopoulou, Timothea; Pol, Hilleke E. Hulshoff; Bohlken, Marc M.; Kahn, Rene S.; Nenadic, Igor; Hultman, Christina M.; Murray, Robin M.; Collier, David A.; Bass, Nick; Gurling, Hugh; McQuillin, Andrew; Schalkwyk, Leonard; Mill, Jonathan
in a total of 1714 individuals from three ...
... Background Altered DNA  methylation 
Breast cancer risk and imprinting methylation in blood
Breast cancer risk and imprinting methylation in blood
Harrison, Kristina; Hoad, Gwen; Scott, Paula; Simpson, Louise; Horgan, Graham W.; Smyth, Elizabeth; Heys, Steven D.; Haggarty, Paul
of imprinted genes has been implicated in ...
... Changes in DNA  methylation 
Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction
Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction
Ions, Laura J; Wakeling, Luisa A; Bosomworth, Helen J; Hardyman, Joy EJ; Escolme, Suzanne M; Swan, Daniel C; Valentine, Ruth A; Mathers, John C; Ford, Dianne
across the life course may contribute to ...
... have identified malignancy-associated DNA  methylation 
Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs
Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs
Roos, Leonie; van Dongen, Jenny; Bell, Christopher G.; Burri, Andrea; Deloukas, Panos; Boomsma, Dorret I.; Spector, Tim D.; Bell, Jordana T.
changes in blood, yet no general cancer ...
... investigate the use of quantitative CGI  methylation 
Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection
Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection
Elliott, Giles O.; Johnson, Ian T.; Scarll, Jane; Dainty, Jack; Williams, Elizabeth A.; Garg, D.; Coupe, Amanda; Bradburn, David M.; Mathers, John C.; Belshaw, Nigel J.
data from stool DNA to classify colon ...
... HSCT. Methods We measured DNA  methylation 
A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation
A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation
Paul, Dirk S.; Jones, Allison; Sellar, Rob S.; Mayor, Neema P.; Feber, Andrew; Webster, Amy P.; Afonso, Neuza; Sergeant, Ruhena; Szydlo, Richard M.; Apperley, Jane F.; Widschwendter, Martin; Mackinnon, Stephen; Marsh, Steven G. E.; Madrigal, J. Alejandro; Rakyan, Vardhman K.; Peggs, Karl S.; Beck, Stephan
levels genome-wide at single-nucleotide ...
... Background DNA  methylation 
Lsh regulates LTR retrotransposon repression independently of Dnmt3b function
Lsh regulates LTR retrotransposon repression independently of Dnmt3b function
Dunican, Donncha S; Cruickshanks, Hazel A; Suzuki, Masako; Semple, Colin A; Davey, Tracey; Arceci, Robert J; Greally, John; Adams, Ian R; Meehan, Richard R
contributes to genomic integrity by ...
... Background DNA  methylation 
Quantification of epigenetic biomarkers: an evaluation of established and emerging methods for DNA methylation analysis
Quantification of epigenetic biomarkers: an evaluation of established and emerging methods for DNA methylation analysis
Redshaw, Nicholas; Huggett, Jim F; Taylor, Martin S; Foy, Carole A; Devonshire, Alison S
is an important epigenetic mechanism in ...