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... poor patient’s prognosis. Beside promoter  methylation 
Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme
Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme
Oberstadt, Moritz C; Bien-Möller, Sandra; Weitmann, Kerstin; Herzog, Susann; Hentschel, Katharina; Rimmbach, Christian; Vogelgesang, Silke; Balz, Ellen; Fink, Matthias; Michael, Heike; Zeden, Jan-Philip; Bruckmüller, Henrike; Werk, Anneke N; Cascorbi, Ingolf; Hoffmann, Wolfgang; Rosskopf, Dieter; Schroeder, Henry WS; Kroemer, Heyo K
of the O 6 ...
... studies have investigated global DNA  methylation 
Blood-based DNA methylation as biomarker for breast cancer: a systematic review
Blood-based DNA methylation as biomarker for breast cancer: a systematic review
Tang, Qiuqiong; Cheng, Jie; Cao, Xue; Surowy, Harald; Burwinkel, Barbara
profiles and gene-specific DNA ...
... Total DNA  methylation 
The correlation of genome size and DNA methylation rate in metazoans
The correlation of genome size and DNA methylation rate in metazoans
Lechner, Marcus; Marz, Manja; Ihling, Christian; Sinz, Andrea; Stadler, Peter F.; Krauss, Veiko
rates are well known to vary widely ...
... however, the role of aberrant DNA  methylation 
Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas
Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas
Renner, Marcus; Wolf, Thomas; Meyer, Hannah; Hartmann, Wolfgang; Penzel, Roland; Ulrich, Alexis; Lehner, Burkhard; Hovestadt, Volker; Czwan, Esteban; Egerer, Gerlinde; Schmitt, Thomas; Alldinger, Ingo; Renker, Eva Kristin; Ehemann, Volker; Eils, Roland; Wardelmann, Eva; Büttner, Reinhard; Lichter, Peter; Brors, Benedikt; Schirmacher, Peter; Mechtersheimer, Gunhild
in these tumors is not well understood ...
... DNA  methylation 
DNA methylation in an engineered heart tissue model of cardiac hypertrophy: common signatures and effects of DNA methylation inhibitors
DNA methylation in an engineered heart tissue model of cardiac hypertrophy: common signatures and effects of DNA methylation inhibitors
Stenzig, Justus; Hirt, Marc N.; Löser, Alexandra; Bartholdt, Lena M.; Hensel, Jan-Tobias; Werner, Tessa R.; Riemenschneider, Mona; Indenbirken, Daniela; Guenther, Thomas; Müller, Christian; Hübner, Norbert; Stoll, Monika; Eschenhagen, Thomas
affects transcriptional regulation and ...
... Background Differential DNA  methylation 
Non-imprinted allele-specific DNA methylation on human autosomes
Non-imprinted allele-specific DNA methylation on human autosomes
Zhang, Yingying; Rohde, Christian; Reinhardt, Richard; Voelcker-Rehage, Claudia; Jeltsch, Albert
between alleles is well established in ...
... DNA  methylation 
DNA METHYLTRANSFERASE 1 is involved in mCG and mCCG DNA methylation and is essential for sporophyte development in Physcomitrella patens
DNA METHYLTRANSFERASE 1 is involved in mCG and mCCG DNA methylation and is essential for sporophyte development in Physcomitrella patens
Yaari, Rafael; Noy-Malka, Chen; Wiedemann, Gertrud; Auerbach Gershovitz, Nitzan; Reski, Ralf; Katz, Aviva; Ohad, Nir
has a crucial role in plant development ...
... hope for improved therapy. Aberrant  methylation 
Frequent but borderline methylation of p16INK4a and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses
Frequent but borderline methylation of p16INK4a and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses
Mühlisch, J.; Bajanowski, T.; Rickert, C. H.; Roggendorf, W.; Würthwein, G.; Jürgens, H.; Frühwald, M. C.
is common in malignant brain tumors of ...
... obesity. We hypothesised that global DNA  methylation 
Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis
Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis
Keller, Maria; Kralisch, Susan; Rohde, Kerstin; Schleinitz, Dorit; Dietrich, Arne; Schön, Michael R.; Gärtner, Daniel; Lohmann, Tobias; Dreßler, Miriam; Tönjes, Anke; Stumvoll, Michael; Kovacs, Peter; Fasshauer, Mathias; Blüher, Matthias; Böttcher, Yvonne
levels in adipose tissue might be ...
... Background Aberrant DNA  methylation 
Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia
Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia
Sonnet, Miriam; Claus, Rainer; Becker, Natalia; Zucknick, Manuela; Petersen, Jana; Lipka, Daniel B; Oakes, Christopher C; Andrulis, Mindaugas; Lier, Amelie; Milsom, Michael D; Witte, Tania; Gu, Lei; Kim-Wanner, Soo-Zin; Schirmacher, Peter; Wulfert, Michael; Gattermann, Norbert; Lübbert, Michael; Rosenbauer, Frank; Rehli, Michael; Bullinger, Lars; Weichenhan, Dieter; Plass, Christoph
is frequently found in human malignancies ...
...  Methylation 
DNA Methylation in Heart Failure
DNA Methylation in Heart Failure
Stenzig, Justus; Foo, Roger S-Y
of cytosine residues in DNA is an ...
... and the importance of aberrant DNA  methylation 
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
Heyn, Holger; Vidal, Enrique; Ferreira, Humberto J.; Vizoso, Miguel; Sayols, Sergi; Gomez, Antonio; Moran, Sebastian; Boque-Sastre, Raquel; Guil, Sonia; Martinez-Cardus, Anna; Lin, Charles Y.; Royo, Romina; Sanchez-Mut, Jose V.; Martinez, Ramon; Gut, Marta; Torrents, David; Orozco, Modesto; Gut, Ivo; Young, Richard A.; Esteller, Manel
profiles is increasingly recognized. ...
... LINE-1 promoter are equally affected by  methylation 
Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs
Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs
Nüsgen, Nicole; Goering, Wolfgang; Dauksa, Albertas; Biswas, Arijit; Jamil, Muhammad Ahmer; Dimitriou, Ioanna; Sharma, Amit; Singer, Heike; Fimmers, Rolf; Fröhlich, Holger; Oldenburg, Johannes; Gulbinas, Antanas; Schulz, Wolfgang A; El-Maarri, Osman
changes. ...
... role of epigenetic mechanisms such as DNA  methylation 
On the potential of models for location and scale for genome-wide DNA methylation data
On the potential of models for location and scale for genome-wide DNA methylation data
Wahl, Simone; Fenske, Nora; Zeilinger, Sonja; Suhre, Karsten; Gieger, Christian; Waldenberger, Melanie; Grallert, Harald; Schmid, Matthias
in disease processes is obtained. ...
... Methods We assessed S-COMT promoter  methylation 
Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults
Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults
Schreiner, Felix; El-Maarri, Osman; Gohlke, Bettina; Stutte, Sonja; Nuesgen, Nicole; Mattheisen, Manuel; Fimmers, Rolf; Bartmann, Peter; Oldenburg, Johannes; Woelfle, Joachim
in saliva and blood derived DNA with ...
... There is increasing evidence for  methylation 
Methylation-based classification of benign and malignant peripheral nerve sheath tumors
Methylation-based classification of benign and malignant peripheral nerve sheath tumors
Röhrich, Manuel; Koelsche, Christian; Schrimpf, Daniel; Capper, David; Sahm, Felix; Kratz, Annekathrin; Reuss, Jana; Hovestadt, Volker; Jones, David T. W.; Bewerunge-Hudler, Melanie; Becker, Albert; Weis, Joachim; Mawrin, Christian; Mittelbronn, Michel; Perry, Arie; Mautner, Victor-Felix; Mechtersheimer, Gunhild; Hartmann, Christian; Okuducu, Ali Fuat; Arp, Mirko; Seiz-Rosenhagen, Marcel; Hänggi, Daniel; Heim, Stefanie; Paulus, Werner; Schittenhelm, Jens; Ahmadi, Rezvan; Herold-Mende, Christel; Unterberg, Andreas; Pfister, Stefan M.; Deimling, Andreas; Reuss, David E.
profiling being able to delineate ...
... report on a genome-wide analysis of DNA  methylation 
Gliomatosis cerebri: no evidence for a separate brain tumor entity
Gliomatosis cerebri: no evidence for a separate brain tumor entity
Herrlinger, Ulrich; Jones, David T. W.; Glas, Martin; Hattingen, Elke; Gramatzki, Dorothee; Stuplich, Moritz; Felsberg, Jörg; Bähr, Oliver; Gielen, Gerrit H.; Simon, Matthias; Wiewrodt, Dorothee; Schabet, Martin; Hovestadt, Volker; Capper, David; Steinbach, Joachim P.; Deimling, Andreas; Lichter, Peter; Pfister, Stefan M.; Weller, Michael; Reifenberger, Guido
and copy number aberrations in 25 GC ...
... in old age are poorly understood. DNA  methylation 
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
Hahn, Oliver; Grönke, Sebastian; Stubbs, Thomas M.; Ficz, Gabriella; Hendrich, Oliver; Krueger, Felix; Andrews, Simon; Zhang, Qifeng; Wakelam, Michael J.; Beyer, Andreas; Reik, Wolf; Partridge, Linda
could play an important role in mediating ...
... of both genetic variants and promoter  methylation 
The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation
The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation
Li-Tempel, Ting; Larra, Mauro F.; Sandt, Estelle; Mériaux, Sophie B.; Schote, Andrea B.; Schächinger, Hartmut; Muller, Claude P.; Turner, Jonathan D.
of the NR3C1 (glucocorticoid receptor) ...
... phenotype, we performed a genome-wide  methylation 
DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations
DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations
Sharma, Amit; Jamil, Muhammad Ahmer; Nuesgen, Nicole; Schreiner, Felix; Priebe, Lutz; Hoffmann, Per; Herns, Stefan; Nöthen, Markus M.; Fröhlich, Holger; Oldenburg, Johannes; Woelfle, Joachim; El-Maarri, Osman
analysis using MeDIP and Illumina’s ...
... in GDM was set on gene-specific DNA  methylation 
Increased global placental DNA methylation levels are associated with gestational diabetes
Increased global placental DNA methylation levels are associated with gestational diabetes
Reichetzeder, C.; Dwi Putra, S. E.; Pfab, T.; Slowinski, T.; Neuber, C.; Kleuser, B.; Hocher, B.
analyses. ...
... we mapped for the first time global DNA  methylation 
Deep sequencing reveals increased DNA methylation in chronic rat epilepsy
Deep sequencing reveals increased DNA methylation in chronic rat epilepsy
Kobow, Katja; Kaspi, Antony; Harikrishnan, K. N.; Kiese, Katharina; Ziemann, Mark; Khurana, Ishant; Fritzsche, Ina; Hauke, Jan; Hahnen, Eric; Coras, Roland; Mühlebner, Angelika; El-Osta, Assam; Blümcke, Ingmar
patterns in chronic epileptic rats and ...
... structure is captured by whole-genome DNA  methylation 
Genome-wide methylation data mirror ancestry information
Genome-wide methylation data mirror ancestry information
Rahmani, Elior; Shenhav, Liat; Schweiger, Regev; Yousefi, Paul; Huen, Karen; Eskenazi, Brenda; Eng, Celeste; Huntsman, Scott; Hu, Donglei; Galanter, Joshua; Oh, Sam S.; Waldenberger, Melanie; Strauch, Konstantin; Grallert, Harald; Meitinger, Thomas; Gieger, Christian; Holland, Nina; Burchard, Esteban G.; Zaitlen, Noah; Halperin, Eran
data. ...
... Background Newly established blood DNA  methylation 
Smoking-associated DNA methylation markers predict lung cancer incidence
Smoking-associated DNA methylation markers predict lung cancer incidence
Zhang, Yan; Elgizouli, Magdeldin; Schöttker, Ben; Holleczek, Bernd; Nieters, Alexandra; Brenner, Hermann
markers that are strongly associated with ...
... Identifying genetic loci where DNA  methylation 
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
Ligthart, Symen; Marzi, Carola; Aslibekyan, Stella; Mendelson, Michael M.; Conneely, Karen N.; Tanaka, Toshiko; Colicino, Elena; Waite, Lindsay L.; Joehanes, Roby; Guan, Weihua; Brody, Jennifer A.; Elks, Cathy; Marioni, Riccardo; Jhun, Min A.; Agha, Golareh; Bressler, Jan; Ward-Caviness, Cavin K.; Chen, Brian H.; Huan, Tianxiao; Bakulski, Kelly; Salfati, Elias L.; Fiorito, Giovanni; Wahl, Simone; Schramm, Katharina; Sha, Jin; Hernandez, Dena G.; Just, Allan C.; Smith, Jennifer A.; Sotoodehnia, Nona; Pilling, Luke C.; Pankow, James S.; Tsao, Phil S.; Liu, Chunyu; Zhao, Wei; Guarrera, Simonetta; Michopoulos, Vasiliki J.; Smith, Alicia K.; Peters, Marjolein J.; Melzer, David; Vokonas, Pantel; Fornage, Myriam; Prokisch, Holger; Bis, Joshua C.; Chu, Audrey Y.; Herder, Christian; Grallert, Harald; Yao, Chen; Shah, Sonia; McRae, Allan F.; Lin, Honghuang; Horvath, Steve; Fallin, Daniele; Hofman, Albert; Wareham, Nicholas J.; Wiggins, Kerri L.; Feinberg, Andrew P.; Starr, John M.; Visscher, Peter M.; Murabito, Joanne M.; Kardia, Sharon L. R.; Absher, Devin M.; Binder, Elisabeth B.; Singleton, Andrew B.; Bandinelli, Stefania; Peters, Annette; Waldenberger, Melanie; Matullo, Giuseppe; Schwartz, Joel D.; Demerath, Ellen W.; Uitterlinden, André G.; van Meurs, Joyce B. J.; Franco, Oscar H.; Chen, Yii-Der Ida; Levy, Daniel; Turner, Stephen T.; Deary, Ian J.; Ressler, Kerry J.; Dupuis, Josée; Ferrucci, Luigi; Ong, Ken K.; Assimes, Themistocles L.; Boerwinkle, Eric; Koenig, Wolfgang; Arnett, Donna K.; Baccarelli, Andrea A.; Benjamin, Emelia J.; Dehghan, Abbas; WHI-EMPC Investigators; CHARGE epigenetics of Coronary Heart Disease
is associated with chronic low-grade ...