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... and neurotransmission. The guanylate  cyclase 
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
Winger, Jonathan A; Derbyshire, Emily R; Lamers, Meindert H; Marletta, Michael A; Kuriyan, John
catalytic module, for which no structure has ...
... receptors [GABAB], known to inhibit adenylyl  cyclase 
Simultaneous stimulation of GABA and beta adrenergic receptors stabilizes isotypes of activated adenylyl cyclase heterocomplex
Simultaneous stimulation of GABA and beta adrenergic receptors stabilizes isotypes of activated adenylyl cyclase heterocomplex
Robichon, Alain; Tinette, Sylvette; Courtial, Cédric; Pelletier, Franck
via Gi. ...
... resulted in the recognition of potential  cyclase 
Computational recognition and analysis of hitherto uncharacterized nucleotide cyclase-like proteins in bacteria
Computational recognition and analysis of hitherto uncharacterized nucleotide cyclase-like proteins in bacteria
Ramakrishnan, Gayatri; Jain, Abha; Chandra, Nagasuma; Srinivasan, Narayanaswamy
function conferring residues and presence of ...
... to adrenaline, is produced by adenylyl  cyclase 
Guanylyl cyclase sees the light
Guanylyl cyclase sees the light
Tesmer, John JG
, an enzyme first characterized in 1958. ...
... extent than in wild type cells. Adenylyl  cyclase 
A novel Dictyostelium RasGEF required for chemotaxis and development
A novel Dictyostelium RasGEF required for chemotaxis and development
Arigoni, Maddalena; Bracco, Enrico; Lusche, Daniel F; Kae, Helmut; Weeks, Gerald; Bozzaro, Salvatore
activation in response to cAMP pulses is ...
... number of receptor kinases contain guanylate  cyclase 
Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1
Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1
Muleya, Victor; Wheeler, Janet I; Ruzvidzo, Oziniel; Freihat, Lubna; Manallack, David T; Gehring, Chris; Irving, Helen R
(GC) catalytic centres encapsulated in the ...
... stress and fever. In this study, an adenylate  cyclase 
The adenylate cyclase gene MaAC is required for virulence and multi-stress tolerance of Metarhizium acridum
The adenylate cyclase gene MaAC is required for virulence and multi-stress tolerance of Metarhizium acridum
Liu, Shuyang; Peng, Guoxiong; Xia, Yuxian
gene (MaAC) was cloned from the ...
... of the Bordetella pertussis adenylate  cyclase 
Development of a Premature Stop Codon-detection method based on a bacterial two-hybrid system
Development of a Premature Stop Codon-detection method based on a bacterial two-hybrid system
Real, Sebastián M; Marzese, Diego M; Gomez, Laura C; Mayorga, Luis S; Roqué, María
triggers the production of cAMP giving rise ...
... GC receptor [18]. The region between the  cyclase 
Multiple lineage specific expansions within the guanylyl cyclase gene family
Multiple lineage specific expansions within the guanylyl cyclase gene family
Fitzpatrick, David A; O'Halloran, Damien M; Burnell, Ann M
domain and the KHD forms a coiled-coil ...
... GPCRs that function by inhibiting adenylate  cyclase 
Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion
Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion
Chigaev, Alexandre; Smagley, Yelena; Sklar, Larry A
and inducing calcium mobilization. ...
... Background Lycopene β-  cyclase 
The lycopene β-cyclase plays a significant role in provitamin A biosynthesis in wheat endosperm
The lycopene β-cyclase plays a significant role in provitamin A biosynthesis in wheat endosperm
Zeng, Jian; Wang, Cheng; Chen, Xi; Zang, Mingli; Yuan, Cuihong; Wang, Xiatian; Wang, Qiong; Li, Miao; Li, Xiaoyan; Chen, Ling; Li, Kexiu; Chang, Junli; Wang, Yuesheng; Yang, Guangxiao; He, Guangyuan
(LCYB) is a key enzyme catalyzing the ...
... EAL domain of STM1703, solely, diguanylate  cyclase 
Detailed analysis of c-di-GMP mediated regulation of csgD expression in Salmonella typhimurium
Detailed analysis of c-di-GMP mediated regulation of csgD expression in Salmonella typhimurium
Ahmad, Irfan; Cimdins, Annika; Beske, Timo; Römling, Ute
and phosphodiesterase activities are required ...
... showed that members of the polyketide  cyclase 
The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands
The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands
Radauer, Christian; Lackner, Peter; Breiteneder, Heimo
family and the activator of Hsp90 ATPase ...
... activation’, consisting of four adenylate  cyclase 
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells
Boettcher, Michael; Lawson, Andrew; Ladenburger, Viola; Fredebohm, Johannes; Wolf, Jonas; Hoheisel, Jörg D; Frezza, Christian; Shlomi, Tomer
genes ADCY3, ADCY6, ADCY7 and ADCY9 (out of a ...
... Methods Cyclic AMP production, adenylyl  cyclase 
Altered collecting duct adenylyl cyclase content in collecting duct endothelin-1 knockout mice
Altered collecting duct adenylyl cyclase content in collecting duct endothelin-1 knockout mice
Strait, Kevin A; Stricklett, Peter K; Kohan, Donald E
(AC) mRNA, and AC protein were measured in ...
... antidepressant treatment increases adenylyl  cyclase 
Differential effects of antidepressants escitalopram versus lithium on Gs alpha membrane relocalization
Differential effects of antidepressants escitalopram versus lithium on Gs alpha membrane relocalization
Donati, Robert J; Schappi, Jeffrey; Czysz, Andrew H; Jackson, Alexander; Rasenick, Mark M
(AC) activity. ...
... phosphodiesterases or changes in adenylate  cyclase 
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
Schermuly, Ralph T; Pullamsetti, Soni S; Breitenbach, Susanne C; Weissmann, Norbert; Ghofrani, Hossein A; Grimminger, Friedrich; Nilius, Sigrid M; Schrör, Karsten; Meger-Kirchrath, Jutta; Seeger, Werner; Rose, Frank
activity, as suggested by unaltered ...
... hydrophila has been shown to possess adenylyl  cyclase 
The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates
The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates
Iyer, Lakshminarayan M; Aravind, L
activity. ...
... Background The soluble guanylyl  cyclase 
Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase
Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase
Ma, Xiaolei; Beuve, Annie; van den Akker, Focco
(sGC) is a heterodimeric enzyme that, upon ...
... CD38 gene expression and CD38 ADP-ribosyl  cyclase 
HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms
HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms
Mamik, Manmeet K; Banerjee, Sugato; Walseth, Timothy F; Hirte, Renee; Tang, Lin; Borgmann, Kathleen; Ghorpade, Anuja
activity assays were performed to analyze ...
... morphine acts via inhibition of adenylate  cyclase 
The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway
The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway
Vetter, Irina; Wyse, Bruce D; Monteith, Gregory R; Roberts-Thomson, Sarah J; Cabot, Peter J
to inhibit PKA-potentiated TRPV1 responses. ...
... G-protein linked adenylyl  cyclase 
Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideumcells
Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideumcells
Sultana, Hameeda; Neelakanta, Girish; Rivero, Francisco; Blau-Wasser, Rosemarie; Schleicher, Michael; Noegel, Angelika A
pathways are crucially involved and a mutant ...
... cytochrome P450 monooxygenases and a putative  cyclase 
Comparative transcriptomics of mountain pine beetle pheromone-biosynthetic tissues and functional analysis of CYP6DE3
Comparative transcriptomics of mountain pine beetle pheromone-biosynthetic tissues and functional analysis of CYP6DE3
Nadeau, J. A.; Petereit, J.; Tillett, R. L.; Jung, K.; Fotoohi, M.; MacLean, M.; Young, S.; Schlauch, K.; Blomquist, G. J.; Tittiger, C.
for further studies. ...
... in carotenoid metabolism. Lycopene β-  cyclase 
Isolation and functional characterization of Lycopene β-cyclase (CYC-B) promoter from Solanum habrochaites
Isolation and functional characterization of Lycopene β-cyclase (CYC-B) promoter from Solanum habrochaites
Dalal, Monika; Chinnusamy, Viswanathan; Bansal, Kailash C
is one of the crucial enzymes in carotenoid ...
... for CNP-dependent activation of the guanylyl  cyclase 
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase regulates oocyte meiotic resumption
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase regulates oocyte meiotic resumption
Shuhaibar, Leia C; Edmund, Aaron B; Egbert, Jeremy R; Yee, Siu-Pok; Potter, Lincoln R; Jaffe, Laurinda A
activity of NPR2. ...