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... catalyzing cADPR formation, ADP-ribosyl  cyclase 
Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds
Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds
Kannt, Aimo; Sicka, Kerstin; Kroll, Katja; Kadereit, Dieter; Gögelein, Heinz
(ADPRC), was first purified from Aplysia ...
... However, for many processes, the adenylyl  cyclase 
Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps
Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps
Ostrom, Rennolds S.; Bogard, Amy S.; Gros, Robert; Feldman, Ross D.
isoforms have been thought of as essentially ...
... we analyzed the β-receptor-mediated adenylyl  cyclase 
Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells
Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells
Hoffmann, C.; Leitz, M. R.; Oberdorf-Maass, S.; Lohse, M. J.; Klotz, K.-N.
activity in isolated membranes from these ...
... inhibitor) and methylene blue (guanylyl  cyclase 
Cardiac dysrhythmia produced by Mesobuthus tamulus venom involves NO-dependent G-Cyclase signaling pathway
Cardiac dysrhythmia produced by Mesobuthus tamulus venom involves NO-dependent G-Cyclase signaling pathway
Kanoo, Sadhana; Mandal, Maloy B.; Alex, Anitha B.; Deshpande, Shripad B.
inhibitor). ...
... of these compounds, whereas adenylyl  cyclase 
Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors
Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors
Jensen, Kyle; Johnson, L’Aurelle A.; Jacobson, Pamala A.; Kachler, Sonja; Kirstein, Mark N.; Lamba, Jatinder; Klotz, Karl-Norbert
activity was used to assess the binding to ...
... studies have shown an activation of adenylyl  cyclase 
Spontaneous release of GDP from Gi proteins and inhibition of adenylyl cyclase in cardiac sarcolemmal membranes
Spontaneous release of GDP from Gi proteins and inhibition of adenylyl cyclase in cardiac sarcolemmal membranes
Lutz, Susanne; Baltus, Doris; Jakobs, Karl H.; Niroomand, Feraydoon
by the G protein-inactivating guanine ...
... (IbTX), blockers of soluble guanylyl  cyclase 
Mechanisms involved in the nitric oxide-induced vasorelaxation in porcine prostatic small arteries
Mechanisms involved in the nitric oxide-induced vasorelaxation in porcine prostatic small arteries
Fernandes, Vítor S.; Martínez-Sáenz, Ana; Recio, Paz; Ribeiro, Ana S. F.; Sánchez, Ana; Martínez, María Pilar; Martínez, Ana Cristina; García-Sacristán, Albino; Orensanz, Luis M.; Prieto, Dolores; Hernández, Medardo
and large conductance Ca2+-activated K+ ...
... (3 Hz) were stimulated with the adenylyl  cyclase 
Reactive oxygen species potentiate the negative inotropic effect of cardiac M2-muscarinic receptor stimulation
Reactive oxygen species potentiate the negative inotropic effect of cardiac M2-muscarinic receptor stimulation
Peters, Stephan L.; Sand, Carsten; Batink, Harry D.; Pfaffendorf, Martin; van Zwieten, Pieter A.
activator forskolin (1 µM). ...
... profiles and ability to activate adenylyl  cyclase 
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution
Krobert, Kurt A.; Bach, Trond; Syversveen, Trygve; Kvingedal, Ane; Levy, Finn
. ...
... of rabbit myocardium, inhibition of adenylate  cyclase 
GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists
GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists
Jakobs, Karl H.; Aktories, Klaus; Schultz, Günter
(EC 4.6.1.1) by cholinergic agonists was ...
... concentration-dependent increase in adenylyl  cyclase 
Chronic muscarinic cholinoceptor stimulation increases adenylyl cyclase responsiveness in rat cardiomyocytes by a decrease in the level of inhibitory G-protein α-subunits
Chronic muscarinic cholinoceptor stimulation increases adenylyl cyclase responsiveness in rat cardiomyocytes by a decrease in the level of inhibitory G-protein α-subunits
Reithmann, C.; Werdan, K.
stimulation by the \-adrenoceptor agonist ...
... that direct activators of adenylyl  cyclase 
Evidence for a significant role of a Gs-triggered mechanism unrelated to the activation of adenylyl cyclase in the cyclic AMP-independent relaxant response of guinea-pig tracheal smooth muscle
Evidence for a significant role of a Gs-triggered mechanism unrelated to the activation of adenylyl cyclase in the cyclic AMP-independent relaxant response of guinea-pig tracheal smooth muscle
Tanaka, Yoshio; Yamashita, Yoko; Yamaki, Fumiko; Horinouchi, Takahiro; Shigenobu, Koki; Koike, Katsuo
, such as forskolin and membrane-permeable ...
... receptors is coupled to platelet adenylate  cyclase 
Characterization of α- and β-adrenergic receptors linked to human platelet adenylate cyclase
Characterization of α- and β-adrenergic receptors linked to human platelet adenylate cyclase
Jakobs, Karl H.; Saur, Wilhelm; Schultz, Günter
. ...
... propanol-1 and butanol-1 on adenylate  cyclase 
Effects of short-chain alcohols on adenylate cyclase in plasma membranes of rat adipocytes
Effects of short-chain alcohols on adenylate cyclase in plasma membranes of rat adipocytes
Stock, K.; Schmidt, M.
activity were studied in the absence (basal) ...
... bovine adrenal cortex is described. Adenylate  cyclase 
Bovine adrenal cortex adenylate cyclase: Properties of the particulate enzyme and effects of guanyl nucleotides
Bovine adrenal cortex adenylate cyclase: Properties of the particulate enzyme and effects of guanyl nucleotides
Glossmann, Hartmut; Gips, Holger
in this particulate preparation retained high ...
... of the hamster adipocyte adenylate  cyclase 
Inactivation of the guanine nucleotide regulatory site mediating inhibition of the adenylate cyclase in hamster adipocytes
Inactivation of the guanine nucleotide regulatory site mediating inhibition of the adenylate cyclase in hamster adipocytes
Aktories, Klaus; Schultz, Günter; Jakobs, Karl H.
. ...
... Supersensitivity of adenylyl  cyclase 
Receptor crosstalk: effects of prolonged carbachol exposure on β1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes
Receptor crosstalk: effects of prolonged carbachol exposure on β1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes
Paraschos, Alexander; Karliner, Joel S.
after exposure to inhibitory agonists is a ...
... targeting D2 and 5-HT1A sites. Adenylyl  cyclase 
Differential profile of typical, atypical and third generation antipsychotics at human 5-HT7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties
Differential profile of typical, atypical and third generation antipsychotics at human 5-HT7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties
Rauly-Lestienne, Isabelle; Boutet-Robinet, Elisa; Ailhaud, Marie-Christine; Newman-Tancredi, Adrian; Cussac, Didier
(AC) activity was measured in HEK293 cells ...
... (ODQ, an inhibitor of guanylate  cyclase 
Basal cGMP regulates the resting pacemaker potential frequency of cultured mouse colonic interstitial cells of Cajal
Basal cGMP regulates the resting pacemaker potential frequency of cultured mouse colonic interstitial cells of Cajal
Shahi, Pawan Kumar; Choi, Seok; Jeong, Yu Jin; Park, Chan Guk; So, Insuk; Jun, Jae Yeoul
) increased the pacemaker potential ...
... of the β-adrenergic-receptor-linked adenylyl  cyclase 
Receptor-independent sensitization of the adenylyl cylase after chronic treatment with cyclosporine A
Receptor-independent sensitization of the adenylyl cylase after chronic treatment with cyclosporine A
Simonis, G.; Christ, T.; Bährle, S. K.; Pena, M.; Schoen, S. P.; Marquetant, R.; Ravens, U.; Strasser, R. H.
(AC) system contributes to hypertension is ...
... inhibition of forskolin-stimulated adenylate  cyclase 
β23-di- and α/β3-tetrapeptide derivatives as potent agonists at somatostatin sst4 receptors
β23-di- and α/β3-tetrapeptide derivatives as potent agonists at somatostatin sst4 receptors
Nunn, Caroline; Rueping, Magnus; Langenegger, Daniel; Schuepbach, Edi; Kimmerlin, Thierry; Micuch, Peter; Hurth, Konstanze; Seebach, Dieter; Hoyer, Daniel
activity, and stimulation of luciferase ...
... profiles and ability to activate adenylyl  cyclase 
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
Brattelid, Trond; Kvingedal, Ane M.; Krobert, Kurt A.; Andressen, Kjetil W.; Bach, Trond; Hystad, Marit E.; Kaumann, Alberto J.; Levy, Finn Olav
(AC) were compared between four recombinant ...
... opening of KATP and activation of guanylate  cyclase 
Vasodilator effects of KRN2391, levcromakalim and 3-morpholino-sydnonimin in human pial and omental arteries
Vasodilator effects of KRN2391, levcromakalim and 3-morpholino-sydnonimin in human pial and omental arteries
Petersson, Jesper; Ryman, Torsten; Högestätt, Edward D.
may contribute to varying extents to the ...
... studies and modulation of adenylyl  cyclase 
2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors
2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors
Klotz, K.-N.; Camaioni, E.; Volpini, R.; Kachler, S.; Vittori, S.; Cristalli, G.
activity on membranes from CHO cell lines ...
... red blood cells from rats contain adenyl  cyclase 
The β-adrenergic receptor-adenyl-cyclase system of rat reticulocytes
The β-adrenergic receptor-adenyl-cyclase system of rat reticulocytes
Gauger, D.; Kaiser, G.; Quiring, K.; Palm, D.
, the activity of which is predominantly ...