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... counterpart of the “soluble” guanylyl  cyclase 
New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications
New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications
Garthwaite, John
found in tissue homogenates over 30 years ago ...
... In mammals, adenylyl  cyclase 
Measurement of Adenylyl Cyclase Activity in Cell Membranes
Measurement of Adenylyl Cyclase Activity in Cell Membranes
Williams, Robert J.; Kelly, Eamonn
is a family of membrane-bound enzymes that ...
... Two isoforms of guanylate  cyclase 
Guanylate cyclases and associated activator proteins in retinal disease
Guanylate cyclases and associated activator proteins in retinal disease
Hunt, David M.; Buch, Prateek; Michaelides, Michel
, GC1 and GC2 encoded by GUCY2D and GUCY2F, ...
... and, to a degree, inhibition of adenylyl  cyclase 
Identification and Analysis of Function of Heterotrimeric Guanine Nucleotide-Binding Proteins Expressed in Neural Tissue
Identification and Analysis of Function of Heterotrimeric Guanine Nucleotide-Binding Proteins Expressed in Neural Tissue
Milligan, Graeme
activity, it is believed that the a subunits ...
... Gi/o proteins to the inhibition of adenylyl  cyclase 
Signaling Diversity Mediated by Muscarinic Acetylcholine Receptor Subtypes and Evidence for Functional Selectivity
Signaling Diversity Mediated by Muscarinic Acetylcholine Receptor Subtypes and Evidence for Functional Selectivity
Challiss, R.A. John; Thomas, Rachel L.
(AC) activity (6,7). ...
... expressing complementary domains of adenylate  cyclase 
Evidence for direct interactions between the mercuric ion transporter (MerT) and mercuric reductase (MerA) from the Tn501mer operon
Evidence for direct interactions between the mercuric ion transporter (MerT) and mercuric reductase (MerA) from the Tn501mer operon
Schue, Mathieu; Glendinning, Kerry J.; Hobman, Jon L.; Brown, Nigel L.
. ...
... the product, i.e., a cyclic nucleotide in the  cyclase 
Quantitation of Nucleotidyl Cyclase and Cyclic Nucleotide-Sensitive Protein Kinase Activities by Fast-Atom Bombardment Mass Spectrometry
Quantitation of Nucleotidyl Cyclase and Cyclic Nucleotide-Sensitive Protein Kinase Activities by Fast-Atom Bombardment Mass Spectrometry
Newton, Russell P.
assay and the target protein in the kinase ...
... mechanism. G-protein coupled adenylate  cyclase 
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response
Wann, A. K. T.; Knight, M. M.
also regulated the length of chondrocyte ...
... activation’, consisting of four adenylate  cyclase 
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells
Boettcher, Michael; Lawson, Andrew; Ladenburger, Viola; Fredebohm, Johannes; Wolf, Jonas; Hoheisel, Jörg D; Frezza, Christian; Shlomi, Tomer
genes ADCY3, ADCY6, ADCY7 and ADCY9 (out of a ...
... distinct properties of particulate guanylyl  cyclase 
Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes
Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes
Thompson, Iain R.; Mirczuk, Samantha M.; Smith, Lorna; Lessey, Andrew J.; Simbi, Bigboy; Sunters, Andrew; Baxter, Gary F.; Lipscomb, Victoria J.; McGonnell, Imelda M.; Wheeler-Jones, Caroline P.; Mukherjee, Abir; Roberson, Mark S.; McArdle, Craig A.; Fowkes, Robert C.
receptors in somatotropes and reveal that ...
... natriuretic peptide receptor (Npr)2guanylyl  cyclase 
Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model
Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model
Peake, Nicholas; Su, Nyan; Ramachandran, Manoj; Achan, Pramod; Salter, Donald M; Bader, Dan L; Moyes, Amie J; Hobbs, Adrian J; Chowdhury, Tina T
B and -cGMP (Npr2/cGMP) pathway was shown to ...
... the activation of their specific guanylyl  cyclase 
Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes
Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes
Jonas, Kim C.; Melrose, Timothy; Thompson, Iain R.; Baxter, Gary F.; Lipscomb, Victoria J.; Niessen, Stijn J.; Lawson, Charlotte; McArdle, Craig A.; Roberson, Mark S.; McGonnell, Imelda M.; Wheeler-Jones, Caroline P.; Fowkes, Robert C.
receptors (GC-A and GC-B) to generate cGMP. ...
... AC9 ; ACIX ; Adcy9 ; ADCY9 ; Adenylate  cyclase 
ADCY9 (Adenylyl Cyclase 9)
ADCY9 (Adenylyl Cyclase 9)
Antoni, Ferenc András
9 ; Adenylyl ...
... cyclic adenosine monophosphate; AC, adenylate  cyclase 
M
M
Wiltschko, Wolfgang; Kramer, Bernd; Winklhofer, Michael; Lohmann, Kenneth J.; Lohmann, Catherine M. F.; Fransson, Peter; Winklhofer, Michael; Ioannides, Andreas A.; Boeke, Heinz; Salcedo, Ernesto; Restrepo, Diego; Lamont, Elaine Waddington; Amir, Shimon; Lund, James P.; Kolta, Arlette; Schröder, Jürgen; Dphil, Markus Schrenk; Herzog, Walter; Tscharner, Vinzenz von; Clark, Andrea L.; Epstein, Marcelo; Ogawa, Hisashi; Rees, Adrian; Richerson, George; Ide, Chizuka; Tolleson, William H.; Provencio, Ignacio; Arendt, Josephine; Arendt, Josephine; Lalley, P. M.; Windhorst, U.; Windhorst, Uwe; Lalley, Peter M.; Manabe, Toshiya; Grossman, Murray; Shibata, Shigenobu; Bernstein, Daniel M.; Loftus, Elizabeth F.; Tachibana, Tamiko; Ide, Chizuka; Winn, Philip; Maruno, Shunichi; Kato, Kazuo; Kishi, Noriyuki; Sohur, U. Shivraj; Molyneaux, Bradley J.; Arlotta, Paola; Macklis, Jeffrey D.; Suzumura, Akio; Suk, Kyoungho; Lalley, Peter M.; Groat, William C. de; Wulczyn, F. Gregory; Jeka, John; Kiemel, Tim; Nusbaum, Michael P.; Herzog, Walter; Nitabach, Michael N.; Stoeckli, Esther T.; Rodriguez Moncalvo, Veronica G.; Campos, Ana R.; Piazza, Stephen J.; Yates, Bill J.; Windhorst, Uwe; Gielen, Stan C. A. M.; Schieber, Marc H.; Cheney, Paul; Bracha, Vlastislav; Bloedel, James R.; Burke, Robert E.; Taylor, Janet L.; Soechting, John F.; Lom, Barbara; Holmes, Nicholas P.; Calvert, Gemma A.; Spence, Charles; Bittman, Eric L.; Leise, Tanya L.; Lucas, Sylvia; Vereyken, Elly J. F.; Dijkstra, Christine D.; Teunissen, Charlotte E.; Heckman, C. J.; Perreault, Eric; Sandercock, Thomas; Maas, Huub; Lexell, Jan; Biewener, Andrew A.; Dhaher, Yasin Y.; Dhaher, Yasin Y.; Dhaher, Yasin Y.; Perreault, Eric J.; Arendt-Nielsen, Lars; Graven-Nielsen, Thomas; d’Avella, Andrea; Heckman, C. J.; Nichols, T. Richard; Huyghues-Despointes, Clotilde M. J. I.; Takamori, Masaharu; Gottschling, Verena; Yamada, Kiyofumi; Nabeshima, Toshitaka
; pKA, protein kinase A; pKC, protein kinase ...
... itself (through calcium-activated adenylyl  cyclase 
Cyclic AMP Signaling in Pancreatic Islets
Cyclic AMP Signaling in Pancreatic Islets
Furman, Brian; Ong, Wee Kiat; Pyne, Nigel J.
– type VIII- AC VIII) and by the incretin ...
... peptides (NP), pituitary adenylate  cyclase 
Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application
Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application
Baliga, Reshma S.; MacAllister, Raymond J.; Hobbs, Adrian J.
activating peptides (PACAP), adrenomedullin ...
... a bacterial two-hybrid system where adenylate  cyclase 
Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor
Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor
Li, Xiao; Wang, Juan; Shi, Mingxin; Wang, Weishan; Corre, Christophe; Yang, Keqian
activity was reconstituted in Escherichia ...
... G-protein linked adenylyl  cyclase 
Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideumcells
Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideumcells
Sultana, Hameeda; Neelakanta, Girish; Rivero, Francisco; Blau-Wasser, Rosemarie; Schleicher, Michael; Noegel, Angelika A
pathways are crucially involved and a mutant ...
... cAMP synthesis due to uncoupling of adenylyl  cyclase 
Myocardial Phosphodiesterases and Regulation of Cardiac Contractility in Health and Cardiac Disease
Myocardial Phosphodiesterases and Regulation of Cardiac Contractility in Health and Cardiac Disease
Osadchii, Oleg E.
from β-adrenoreceptor. ...
... uncoupling of β-adrenoreceptors and adenylate  cyclase 
Cardiac hypertrophy induced by sustained β-adrenoreceptor activation: pathophysiological aspects
Cardiac hypertrophy induced by sustained β-adrenoreceptor activation: pathophysiological aspects
Osadchii, Oleg E.
, as well as modifications of downstream ...
... nucleotide-generating systems are adenylyl  cyclase 
Methods in Cyclic Nucleotide Research
Methods in Cyclic Nucleotide Research
Murray, Kenneth J.
and guanylyl ...
... profiles and ability to activate adenylyl  cyclase 
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
Brattelid, Trond; Kvingedal, Ane M.; Krobert, Kurt A.; Andressen, Kjetil W.; Bach, Trond; Hystad, Marit E.; Kaumann, Alberto J.; Levy, Finn Olav
(AC) were compared between four recombinant ...
... by combined effects of adenylate  cyclase 
Adenosine Receptors and Asthma
Adenosine Receptors and Asthma
Wilson, Constance N.; Nadeem, Ahmed; Spina, Domenico; Brown, Rachel; Page, Clive P.; Mustafa, S. Jamal
(AC), phosphodiesterases (PDE) and ...
... 1). Cyclic AMP is synthesized by adenylate  cyclase 
Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae
Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae
Williamson, Thomas; Schwartz, Jean-Marc; Kell, Douglas B; Stateva, Lubomira
(Cyr1p), which in turn is regulated by Gpa2p ...
... PACAP PACAP Definition Pituitary adenylyl  cyclase 
P
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Ide, Chizuka; Gebhart, G. F.; Tracey, Irene; McGrath, Patricia A.; Williams, Tricia; Hadjistavropoulos, Thomas; Greenspan, Joel D.; Samii, Ali; Osumi, Noriko; Kerzel, Dirk; Staudacher, Alexander; Murakami, Ikuya; Nicholson, Daniel A.; Geinisman, Yuri; Bell, Harold J.; Midha, Rajiv; Kramer, Achim; Dickman, J. David; Bölter, Annette; Frommer, Jörg; Calford, Mike B.; Colwell, Christopher S.; Hart, Nathan S.; Hatori, Megumi; Panda, Satchidananda; Hart, Nathan S.; Montero, Barbara; Fields, Howard L.; Irvine, Dexter R. F.; Dick, Thomas E.; Dutschmann, Mathias; Morris, Kendall F.; Scudder, Charles; Cullen, Kathleen E.; Medvedev, Svyatoslav V.; Gadenne, Volker; Morris, Judy L.; Gibbins, Ian L.; Miyakawa; Hiroyoshi; Horak, Fay B.; Gurfinkel, Victor S.; Maki, Brian E.; Ting, Lena H.; Peterka, Robert J.; Timmann, Dagmar; Del Negro, Christopher A.; Hayes, John A.; Pace, Ryland W.; Scudder, Charles; Sesack, Susan R.; Rees, Sandra; Quevedo, Jorge N.; Seagar, Michael; Epstein, Marcelo; Wheat, Heather E.; Goodwin, Antony W.; Yaginuma, Hiroyuki; Yaginuma, Hiroyuki; Kim, Julia; Farb, David H.; Russek, Shelley J.; Gadenne, Volker; Gandevia, Simon; Refshauge, Kathryn M.; Lord, Stephen R.; Lackner, James R.; DiZio, Paul; Cole, Jonathan; Collins, David F.; Macefield, Vaughan G.; Macefield, Vaughan G.; Proske, Uwe; Yang, Xiaohang; Schwartz, Michal; Kipnis, Jonathan; Yan, Qin; Mao, Ying-Wei; Li, David W.; Coorssen, Jens R.; Shepherd, Gordon M.; Shepherd-Barr, Kirsten; Buell, Thomas N.; Trahiotis, Constantine; Bernstein, Leslie R.; Ehrenstein, Walter H.; Wurtz, Robert H.
activating peptide; a neuropeptide expressed ...