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... vitro although the release from the imine  conjugate 
Amphotericin B-Gum Arabic Conjugates: Synthesis, Toxicity, Bioavailability, and Activities Against Leishmania and Fungi
Amphotericin B-Gum Arabic Conjugates: Synthesis, Toxicity, Bioavailability, and Activities Against Leishmania and Fungi
Nishi, K. K.; Antony, M.; Mohanan, P. V.; Anilkumar, T. V.; Loiseau, P. M.; Jayakrishnan, A.
was much faster than from the amine ...
... an acute CCl4 model in mice. Results Y27-  conjugate 
Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632
Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632
Beuge, Marike Marjolijn; Prakash, Jai; Lacombe, Marie; Post, Eduard; Reker-Smit, Catharina; Beljaars, Leonie; Poelstra, Klaas
remained stable in serum, while drug was ...
... polyvalent aptamer system (MPAS)  conjugate 
Targeted Delivery of Epirubicin to Cancer Cells by Polyvalent Aptamer System in vitro and in vivo
Targeted Delivery of Epirubicin to Cancer Cells by Polyvalent Aptamer System in vitro and in vivo
Yazdian-Robati, Rezvan; Ramezani, Mohammad; Jalalian, Seyed Hamid; Abnous, Khalil; Taghdisi, Seyed Mohammad
was developed for the treatment of both ...
... of this study is to develop a drug-polymer  conjugate 
A Novel Rapamycin-Polymer Conjugate Based on a New Poly(Ethylene Glycol) Multiblock Copolymer
A Novel Rapamycin-Polymer Conjugate Based on a New Poly(Ethylene Glycol) Multiblock Copolymer
Tai, Wanyi; Chen, Zhijin; Barve, Ashutosh; Peng, Zhonghua; Cheng, Kun
to increase the solubility and cellular ...
... a novel chitosan–glutathione (GSH)  conjugate 
Synthesis and in Vitro Evaluation of a Novel Chitosan–Glutathione Conjugate
Synthesis and in Vitro Evaluation of a Novel Chitosan–Glutathione Conjugate
Kafedjiiski, Krum; Föger, Florian; Werle, Martin; Bernkop-Schnürch, Andreas
providing improved mucoadhesive and ...
... with a pegylated bifunctional polymer  conjugate 
Contrast-Enhanced MRI-Guided Photodynamic Cancer Therapy with a Pegylated Bifunctional Polymer Conjugate
Contrast-Enhanced MRI-Guided Photodynamic Cancer Therapy with a Pegylated Bifunctional Polymer Conjugate
Vaidya, Anagha; Sun, Yongen; Feng, Yi; Emerson, Lyska; Jeong, Eun-Kee; Lu, Zheng-Rong
containing an MRI contrast agent and a ...
... were treated with a single dose of the  conjugate 
Preclinical Evaluation of Linear HPMA-Doxorubicin Conjugates with pH-Sensitive Drug Release: Efficacy, Safety, and Immunomodulating Activity in Murine Model
Preclinical Evaluation of Linear HPMA-Doxorubicin Conjugates with pH-Sensitive Drug Release: Efficacy, Safety, and Immunomodulating Activity in Murine Model
Sirova, Milada; Mrkvan, Tomas; Etrych, Tomas; Chytil, Petr; Rossmann, Pavel; Ibrahimova, Marketa; Kovar, Lubomir; Ulbrich, Karel; Rihova, Blanka
(15, 25, and 75 mg Dox eq./kg i.v.) in a ...
... therapy with a chemo-immunotherapeutic  conjugate 
Anticancer and Immunostimulatory Activity by Conjugate of Paclitaxel and Non-toxic Derivative of LPS for Combined Chemo-immunotherapy
Anticancer and Immunostimulatory Activity by Conjugate of Paclitaxel and Non-toxic Derivative of LPS for Combined Chemo-immunotherapy
Roy, Aniruddha; Chandra, Sourav; Mamilapally, Swapna; Upadhyay, Pramod; Bhaskar, Sangeeta
could be more effective in curing the ...
... the effect of the conformation of the  conjugate 
Stability in Plasmas of Various Species of HPMA Copolymer–PGE1 Conjugates
Stability in Plasmas of Various Species of HPMA Copolymer–PGE1 Conjugates
Pan, Huaizhong; Kopečková, Pavla; Liu, Jihua; Wang, Dong; Miller, Scott C.; Kopeček, Jindřich
on the rate of PGE1 release, its structure ...
... NHS-PEG-MAL. To test the efficacy of the  conjugate 
Antibody-Mediated “Universal” Osteoclast Targeting Platform using Calcitonin as a Model Drug
Antibody-Mediated “Universal” Osteoclast Targeting Platform using Calcitonin as a Model Drug
Newa, Madhuri; Bhandari, Krishna Hari; Tang, Lili; Kalvapalle, Rohit; Suresh, Mavanur; Doschak, Michael R.
in vitro, osteoclasts were generated from ...
... followed by trituration with Et2O yielded  conjugate 
Synthesis and Εvaluation of Αnticancer Αctivity in Cells of Novel Stoichiometric Pegylated Fullerene-Doxorubicin Conjugates
Synthesis and Εvaluation of Αnticancer Αctivity in Cells of Novel Stoichiometric Pegylated Fullerene-Doxorubicin Conjugates
Magoulas, George E.; Bantzi, Marina; Messari, Danai; Voulgari, Efstathia; Gialeli, Chrisostomi; Barbouri, Despoina; Giannis, Athanassios; Karamanos, Nikos K.; Papaioannou, Dionissios; Avgoustakis, Konstantinos
7. ...
... We developed a renally accumulating  conjugate 
Cell-specific Delivery of a Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor to Proximal Tubular Cells for the Treatment of Renal Fibrosis
Cell-specific Delivery of a Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor to Proximal Tubular Cells for the Treatment of Renal Fibrosis
Prakash, Jai; Borst, Martin H.; Loenen-Weemaes, Annemiek M.; Lacombe, Marie; Opdam, Frank; Goor, Harry; Meijer, Dirk K. F.; Moolenaar, Frits; Poelstra, Klaas; Kok, Robbert J.
of a TGF-β type-I receptor kinase inhibitor ...
... Purpose A polysaccharide-flavonoid  conjugate 
Dextran-Catechin Conjugate: A Potential Treatment Against the Pancreatic Ductal Adenocarcinoma
Dextran-Catechin Conjugate: A Potential Treatment Against the Pancreatic Ductal Adenocarcinoma
Vittorio, Orazio; Cirillo, Giuseppe; Iemma, Francesca; Turi, Giovanni; Jacchetti, Emanuela; Curcio, Michele; Barbuti, Serena; Funel, Niccola; Parisi, Ortensia Ilaria; Puoci, Francesco; Picci, Nevio
was developend and proposed for the ...
... amine) dendrimer-camptothecin (PAMAM-CPT)  conjugate 
PAMAM-Camptothecin Conjugate Inhibits Proliferation and Induces Nuclear Fragmentation in Colorectal Carcinoma Cells
PAMAM-Camptothecin Conjugate Inhibits Proliferation and Induces Nuclear Fragmentation in Colorectal Carcinoma Cells
Thiagarajan, Giridhar; Ray, Abhijit; Malugin, Alexander; Ghandehari, Hamidreza
and evaluate its activity on human ...
... To utilize a novel type of polymer-drug  conjugate 
Biodegradable Polymer-Curcumin Conjugate Micelles Enhance the Loading and Delivery of Low-Potency Curcumin
Biodegradable Polymer-Curcumin Conjugate Micelles Enhance the Loading and Delivery of Low-Potency Curcumin
Yang, Rulei; Zhang, Suai; Kong, Deling; Gao, Xuli; Zhao, Yanjun; Wang, Zheng
micelle to enhance the delivery of ...
... insight regarding the major pathways of  conjugate 
Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys
Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys
Lu, Dan; Jin, Jin Yan; Girish, Sandhya; Agarwal, Priya; Li, Dongwei; Prabhu, Saileta; Dere, Randall C.; Saad, Ola M.; Nazzal, Denise; Koppada, Neelima; Ramanujan, Saroja; Ng, Chee M.
elimination and unconjugated MMAE release ...
... served as a model vector. Via the fBSA/WGA  conjugate 
Biomimetic Delivery Strategies at the Urothelium: Targeted Cytoinvasion in Bladder Cancer Cells via Lectin Bioconjugates
Biomimetic Delivery Strategies at the Urothelium: Targeted Cytoinvasion in Bladder Cancer Cells via Lectin Bioconjugates
Neutsch, Lukas; Eggenreich, Britta; Herwig, Ela; Marchetti-Deschmann, Martina; Allmaier, Günter; Gabor, Franz; Wirth, Michael
, it was possible to demonstrate how known ...
... lipid is retained in liposomes using a PEG-  conjugate 
Sheddable Coatings for Long-Circulating Nanoparticles
Sheddable Coatings for Long-Circulating Nanoparticles
Romberg, Birgit; Hennink, Wim E.; Storm, Gert
, the removal of the polymer coating would ...
... (HPMA) copolymer–9-AC  conjugate 
Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer–9-AC Conjugate in Rats
Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer–9-AC Conjugate in Rats
Gao, Song-Qi; Sun, Yongen; Kopečková, Pavla; Peterson, C. Matthew; Kopeček, Jindřich
and its absorption behavior after oral ...
... major polymer formulas, including polymeric  conjugate 
Polymeric Materials for Theranostic Applications
Polymeric Materials for Theranostic Applications
Wang, Zhe; Niu, Gang; Chen, Xiaoyuan
complexes, nanospheres, micelles, and ...
... than 40% of the drug was released from its  conjugate 
Targeted Sialic Acid–Doxorubicin Prodrugs for Intracellular Delivery and Cancer Treatment
Targeted Sialic Acid–Doxorubicin Prodrugs for Intracellular Delivery and Cancer Treatment
Jayant, Sreeja; Khandare, Jayant J.; Wang, Yang; Singh, Ajay P.; Vorsa, Nicholi; Minko, Tamara
in the presence of esterase enzyme, whereas ...
... in PBS and human plasma. Degradation of  conjugate 
Temozolomide Delivery to Tumor Cells by a Multifunctional Nano Vehicle Based on Poly(β-L-malic acid)
Temozolomide Delivery to Tumor Cells by a Multifunctional Nano Vehicle Based on Poly(β-L-malic acid)
Patil, Rameshwar; Portilla-Arias, José; Ding, Hui; Inoue, Satoshi; Konda, Bindu; Hu, Jinwei; Wawrowsky, Kolja A.; Shin, Paul K.; Black, Keith L.; Holler, Eggehard; Ljubimova, Julia Y.
P/LLL(40%)TMZH(17%) in PBS and human plasma ...
... doses (6), an extended half-life of the  conjugate 
The Effect of Molecular Weight, Drug Load, and Charge of Gelatin–MTX Conjugates on Growth Inhibition of HL-60 Leukemia Cells
The Effect of Molecular Weight, Drug Load, and Charge of Gelatin–MTX Conjugates on Growth Inhibition of HL-60 Leukemia Cells
Chen, Chao-Sheng; Ofner, Clyde M., III
in circulation (7,8) a passive intra-tumor ...
... characteristics of an ideal antibody-drug  conjugate 
Optimising the Delivery of Tubulin Targeting Agents through Antibody Conjugation
Optimising the Delivery of Tubulin Targeting Agents through Antibody Conjugation
Stack, Gary D.; Walsh, John J.
along five distinct headings: 1. ...
... K-sensitive linkage to HPMA copolymer–Asp8  conjugate 
Feasibility of Using a Bone-Targeted, Macromolecular Delivery System Coupled with Prostaglandin E1 to Promote Bone Formation in Aged, Estrogen-Deficient Rats
Feasibility of Using a Bone-Targeted, Macromolecular Delivery System Coupled with Prostaglandin E1 to Promote Bone Formation in Aged, Estrogen-Deficient Rats
Miller, S. C.; Pan, H.; Wang, D.; Bowman, B. M.; Kopečková, P.; Kopeček, J.
and was tested to determine if it could ...

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