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... analyze experimental designs of increasing  complexity 
Factorial design and covariance in the study of individual educational development
Factorial design and covariance in the study of individual educational development
Johnson, Palmer O.; Tsao, Fei
since the introduction of the analysis of ...
... especially draws attention to the extreme  complexity 
Psychiatric implications of internal medicine
Psychiatric implications of internal medicine
Steckel, Harry A.
of the human beings with which it deals. ...