Sample Search Results

... Mutations in the TP53 gene or the  p53 
CNS Cancer
p53 Pathway Alterations in Brain Tumors
Yin, Shaoman; Van Meir, Erwin G.
pathway are required for the formation of many ...
... The  p53 
Signaling Pathways in Liver Diseases
p53
Tsai, Wen-Wei; Barton, Michelle Craig
tumor suppressor is well known as the major ...
... Understanding the mechanism underlying  p53 
Journal of Neuro-Oncology
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... No summary available 1 The  p53 
Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy
p53 Inhibitors as Cancer Sensitizing Agents
Maina, Flavio; Dono, Rosanna
Player: A Stage Director for the Fate of Stressed ...
...  p53 
Signal Transduction: Pathways, Mechanisms and Diseases
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Giono, Luciana E.; Manfredi, James J.
is a widely conserved tumor suppressor protein ...
...  p53 
Apoptosis
Targeting p53 for enhanced radio- and chemo-sensitivity
Lu, Chao; El-Deiry, Wafik S.
acts as a central mediator of the cellular ...
... Background The tumor suppressor gene  p53 
Molecular Cancer
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Baumbusch, Lars; Myhre, Simen; Langerød, Anita; Bergamaschi, Anna; Geisler, Stephanie; Lønning, Per; Deppert, Wolfgang; Dornreiter, Irene; Børresen-Dale, Anne-Lise
(TP53) controls numerous signaling pathways and ...
...  p53 
25 Years of p53 Research
Regulation of p53 DNA Binding
McKinney, Kristine; Prives, Carol
is one of the most frequently mutated genes in ...
... The  p53 
Lung Cancer
Clinical Implications of p53 Mutations in Lung Cancer
Campling, Barbara G.; El-Deiry, Wafik S.
tumor-suppressor gene plays a crucial role in the ...
... In this work we present evidence that the  p53 
BMC Immunology
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Dreyfus, David; Nagasawa, Masayuki; Gelfand, Erwin; Ghoda, Lucy
tumor suppressor protein and NF-κB transcription ...
... Happy 25th Anniversary  p53 
25 Years of p53 Research
Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX
Wahl, Geoffrey M.; Stommel, Jayne M.; Krummel, Kurt; Wade, Mark
! Since this is such a special occasion, I (GW) ...
... Single mutations in the DNA binding domain of  p53 
The p53 Tumor Suppressor Pathway and Cancer
The Oncogenic Activity of p53 Mutants
Sigal, Alex; Rotter, Varda
cause a radical shift in function from tumor ...
... The  p53 
The p53 Tumor Suppressor Pathway and Cancer
p53 in Human Cancer — Somatic and Inherited Mutations and Mutation-independent Mechanisms
Moll, Ute M.; Concin, Nicole
tumor suppressor protein plays a central role in ...
... The best-characterized function of  p53 
The p53 Tumor Suppressor Pathway and Cancer
Transcriptional Activation by p53: Mechanisms and Targeted Genes
MacLachlan, Timothy; El-Deiry, Wafik
, the most renowned tumor suppressor, is that of ...
... The  p53 
Cancer and Metastasis Reviews
The p53 protein family and radiation sensitivity: Yes or no?
Cuddihy, Andrew R.; Bristow, Robert G.
tumor suppressor protein is a key mediator of an ...
... The tumor suppressor gene TP53, encoding the  p53 
Cytotoxic Drug Resistance Mechanisms
Analysis of the p53 Status of Tumors
Bergh, Jonas
protein, has its gene locus on the short arm of ...
...  p53 
Journal of Molecular Medicine
Exonucleolytic degradation of RNA by p53 protein in cytoplasm
Bakhanashvili, Mary; Gedelovich, Rachel; Grinberg, Shai; Rahav, Galia
in cytoplasm displays an intrinsic 3′→5′ ...
... The human mutant  p53 
Transgenic Research
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Duan, Wenrui; Gao, Li; Jin, David; Otterson, Gregory A.; Villalona-Calero, Miguel A.
(273H) has been shown in vitro to have both ...
... Background The tumor suppressor protein  p53 
BMC Genomics
p53 induces distinct epigenetic states at its direct target promoters
Vrba, Lukas; Junk, Damian; Novak, Petr; Futscher, Bernard
is a transcription factor that is mutated in many ...
... Background  p53 
Molecular Cancer
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Zhang, Lili; Nie, Linghu; Maki, Carl
is a tumor suppressor and potent inhibitor of ...
... Background  p53 
BMC Genomics
NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
Brynczka, Christopher; Labhart, Paul; Merrick, B Alex
is recognized as a critical regulator of the cell ...
... The tumor suppressor  p53 
Drug Resistance in Cancer Cells
Drug Resistance and the Tumor Suppressor p53: The Paradox of Wild-Type Genotype in Chemorefractory Cancers
Siddik, Zahid H.
has a central role in drug-induced cell death. ...
... the second as backup. Not necessarily so with  p53 
Molecular Cancer
Resistance of mitochondrial p53 to dominant inhibition
Heyne, Kristina; Schmitt, Katrin; Mueller, Daniel; Armbruester, Vivienne; Mestres, Pedro; Roemer, Klaus
. ...
... to the development and progression of cancer. The  p53 
Apoptosis
The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death
Chari, Nikhil S.; Pinaire, Nicole L.; Thorpe, Lynnelle; Medeiros, L. Jeffrey; Routbort, Mark J.; McDonnell, Timothy J.
tumor suppressor protein is among the most ...
...  p53 
Journal of Molecular Medicine
Regulation of tumor suppressor p53 at the RNA level
Vilborg, Anna; Wilhelm, Margareta T.; Wiman, Klas G.
is a key tumor suppressor that triggers cell ...